{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T22:55:23Z","timestamp":1792364123568,"version":"4.4.0"},"reference-count":30,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.3892\/or.2015.4449","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T13:53:31Z","timestamp":1448459611000},"page":"992-998","source":"Crossref","is-referenced-by-count":24,"title":["Hypoxia inducible factor-1 mediates upregulation of urokinase-type plasminogen activator receptor gene transcription during hypoxia in cervical cancer cells"],"prefix":"10.3892","volume":"35","author":[{"given":"HIROTAKA","family":"NISHI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TORU","family":"SASAKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YUZO","family":"NAGAMITSU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FUMITOSHI","family":"TERAUCHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKESHI","family":"NAGAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOSHITAKA","family":"NAGAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KEIICHI","family":"ISAKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2015,11,25]]},"reference":[{"key":"key20180107211140_b1-or-35-02-0992","first-page":"941","article-title":"Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma","volume":"56","author":"Brizel","year":"1996","journal-title":"Cancer Res"},{"key":"key20180107211140_b2-or-35-02-0992","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0360-3016(97)00101-6","article-title":"Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck","volume":"38","author":"Brizel","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"key20180107211140_b3-or-35-02-0992","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00066-002-1081-x","article-title":"Oxygenation status of gynecologic tumors: What is the optimal hemoglobin level?","volume":"178","author":"Vaupel","year":"2002","journal-title":"Strahlenther Onkol"},{"key":"key20180107211140_b4-or-35-02-0992","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.0959-9673.2005.00441.x","article-title":"A novel 3-dimensional culture system as an in vitro model for studying oral cancer cell invasion","volume":"86","author":"Duong","year":"2005","journal-title":"Int J Exp Pathol"},{"key":"key20180107211140_b5-or-35-02-0992","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/sj.onc.1208305","article-title":"Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma","volume":"24","author":"Petrella","year":"2005","journal-title":"Oncogene"},{"key":"key20180107211140_b6-or-35-02-0992","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1006\/excr.1999.4804","article-title":"Both increased stability and transcription contribute to the induction of the urokinase plasminogen activator receptor (uPAR) message by hypoxia","volume":"255","author":"Maity","year":"2000","journal-title":"Exp Cell Res"},{"key":"key20180107211140_b7-or-35-02-0992","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-5793(01)03104-0","article-title":"Urokinase-type plasminogen activator up-regulates the expression of its cellular receptor through a post-transcriptional mechanism","volume":"508","author":"Montuori","year":"2001","journal-title":"FEBS Lett"},{"key":"key20180107211140_b8-or-35-02-0992","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1054\/bjoc.2001.2018","article-title":"Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic\/molecular profile of tumours and survival","volume":"85","author":"Giatromanolaki","year":"2001","journal-title":"Br J Cancer"},{"key":"key20180107211140_b9-or-35-02-0992","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"148","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"key20180107211140_b10-or-35-02-0992","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2007.01.047","article-title":"HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells","volume":"129","author":"Fukuda","year":"2007","journal-title":"Cell"},{"key":"key20180107211140_b11-or-35-02-0992","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1128\/MCB.24.13.6076-6083.2004","article-title":"Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT)","volume":"24","author":"Nishi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"key20180107211140_b12-or-35-02-0992","first-page":"165","article-title":"Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition","volume":"19","author":"McNally","year":"2007","journal-title":"Int J Mol Med"},{"key":"key20180107211140_b13-or-35-02-0992","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)81478-6","article-title":"Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay","volume":"94","author":"Kim","year":"1998","journal-title":"Cell"},{"key":"key20180107211140_b14-or-35-02-0992","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0002-9440(10)65083-3","article-title":"Genetic progression and divergence in pancreatic carcinoma","volume":"156","author":"Yamano","year":"2000","journal-title":"Am J Pathol"},{"key":"key20180107211140_b15-or-35-02-0992","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1093\/jnci\/93.17.1337","article-title":"Transcriptional response to hypoxia in human tumors","volume":"93","author":"Lal","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"key20180107211140_b16-or-35-02-0992","first-page":"883","article-title":"Candidate genes for the hypoxic tumor phenotype","volume":"60","author":"Koong","year":"2000","journal-title":"Cancer Res"},{"key":"key20180107211140_b17-or-35-02-0992","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/(SICI)1097-0215(19990209)80:4<617::AID-IJC22>3.0.CO;2-C","article-title":"Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression","volume":"80","author":"Graham","year":"1999","journal-title":"Int J Cancer"},{"key":"key20180107211140_b18-or-35-02-0992","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1009095825561","article-title":"The urokinase plasminogen activator system in cancer: Implications for tumor angiogenesis and metastasis","volume":"3","author":"Mazar","year":"1999","journal-title":"Angiogenesis"},{"key":"key20180107211140_b19-or-35-02-0992","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1158\/0008-5472.CAN-05-0946","article-title":"Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice","volume":"65","author":"Bauer","year":"2005","journal-title":"Cancer Res"},{"key":"key20180107211140_b20-or-35-02-0992","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2174\/1381612033454612","article-title":"Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): Development of antagonists of uPA\/uPAR interaction and their effects in vitro and in vivo","volume":"9","author":"Reuning","year":"2003","journal-title":"Curr Pharm Des"},{"key":"key20180107211140_b21-or-35-02-0992","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-5793(01)02797-1","article-title":"PAI-1 inhibits urokinase-induced chemotaxis by internalizing the urokinase receptor","volume":"505","author":"Degryse","year":"2001","journal-title":"FEBS Lett"},{"key":"key20180107211140_b22-or-35-02-0992","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-4827(03)00336-7","article-title":"Transforming growth factor-beta1 inhibits tumor growth in a mouse melanoma model by down-regulating the plasminogen activation system","volume":"291","author":"Ramont","year":"2003","journal-title":"Exp Cell Res"},{"key":"key20180107211140_b23-or-35-02-0992","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/path.931","article-title":"Plasminogen activator inhibitor-1 as a measure of vascular remodelling in breast cancer","volume":"195","author":"Fox","year":"2001","journal-title":"J Pathol"},{"key":"key20180107211140_b24-or-35-02-0992","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1593\/neo.08734","article-title":"Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer","volume":"11","author":"B\u00fcchler","year":"2009","journal-title":"Neoplasia"},{"key":"key20180107211140_b25-or-35-02-0992","doi-asserted-by":"crossref","first-page":"12860","DOI":"10.1021\/bi0500731","article-title":"Toward the elucidation of the structural determinants responsible for the molecular recognition between Mad1 and Max","volume":"44","author":"Montagne","year":"2005","journal-title":"Biochemistry"},{"key":"key20180107211140_b26-or-35-02-0992","doi-asserted-by":"crossref","first-page":"11855","DOI":"10.1021\/bi050206i","article-title":"Assembly of b\/HLH\/z proteins c-Myc, Max, and Mad1 with cognate DNA: Importance of protein-protein and protein-DNA interactions","volume":"44","author":"Hu","year":"2005","journal-title":"Biochemistry"},{"key":"key20180107211140_b27-or-35-02-0992","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/abio.2001.5515","article-title":"Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblasts","volume":"302","author":"Semov","year":"2002","journal-title":"Anal Biochem"},{"key":"key20180107211140_b28-or-35-02-0992","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1515\/BC.1999.140","article-title":"DNA binding of Myc\/Max\/Mad network complexes to oligonucleotides containing two E box elements: c-Myc\/Max heterodimers do not bind DNA cooperatively","volume":"380","author":"Vervoorts","year":"1999","journal-title":"Biol Chem"},{"key":"key20180107211140_b29-or-35-02-0992","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/sj.emboj.7600196","article-title":"HIF-1alpha induces cell cycle arrest by functionally counteracting Myc","volume":"23","author":"Koshiji","year":"2004","journal-title":"EMBO J"},{"key":"key20180107211140_b30-or-35-02-0992","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1158\/1535-7163.647.3.5","article-title":"Hypoxia inducible factor-1alpha as a cancer drug target","volume":"3","author":"Powis","year":"2004","journal-title":"Mol Cancer Ther"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2015.4449\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T23:44:30Z","timestamp":1692143070000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2015.4449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,25]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,11,25]]},"published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3892\/or.2015.4449"],"URL":"https:\/\/doi.org\/10.3892\/or.2015.4449","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,25]]}}}