{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:45:14Z","timestamp":1791269114149,"version":"4.1.0"},"reference-count":40,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.3892\/or.2016.4618","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T13:45:30Z","timestamp":1455198330000},"page":"2451-2460","source":"Crossref","is-referenced-by-count":44,"title":["DNA methylation-induced E-cadherin silencing is correlated with the clinicopathological features of melanoma"],"prefix":"10.3892","volume":"35","author":[{"given":"MARIO","family":"VENZA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA","family":"VISALLI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TERESA","family":"CATALANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CARMELO","family":"BIONDO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CONCETTA","family":"BENINATI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIANA","family":"TETI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ISABELLA","family":"VENZA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"issue":"Suppl 7","key":"key20180107210926_b1-or-35-04-2451","doi-asserted-by":"crossref","first-page":"S1728","DOI":"10.1002\/cncr.23643","article-title":"State of the science 60th anniversary review: 60 Years of advances in cutaneous melanoma epidemiology, diagnosis, and treatment, as reported in the journal Cancer","volume":"113","author":"Demierre","year":"2008","journal-title":"Cancer"},{"key":"key20180107210926_b2-or-35-04-2451","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbagrm.2014.12.004","article-title":"Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma","volume":"1849","author":"Venza","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"key20180107210926_b3-or-35-04-2451","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.intimp.2014.05.024","article-title":"Class I-specific histone deacetylase inhibitor MS-275 overrides TRAIL-resistance in melanoma cells by downregulating c-FLIP","volume":"21","author":"Venza","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"key20180107210926_b4-or-35-04-2451","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbrc.2013.10.114","article-title":"Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma","volume":"441","author":"Venza","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107210926_b5-or-35-04-2451","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/pcmr.12049","article-title":"Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells","volume":"26","author":"Venza","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"key20180107210926_b6-or-35-04-2451","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2174\/138920291506150106145932","article-title":"Epigenetic effects of cadmium in cancer: Focus on melanoma","volume":"15","author":"Venza","year":"2014","journal-title":"Curr Genomics"},{"key":"key20180107210926_b7-or-35-04-2451","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/bies.201400141","article-title":"E-cadherin's role in development, tissue homeostasis and disease: Insights from mouse models: Tissue-specific inactivation of the adhesion protein E-cadherin in mice reveals its functions in health and disease","volume":"37","author":"Schneider","year":"2015","journal-title":"BioEssays"},{"key":"key20180107210926_b8-or-35-04-2451","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/modpathol.3800151","article-title":"Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma","volume":"17","author":"Andersen","year":"2004","journal-title":"Mod Pathol"},{"key":"key20180107210926_b9-or-35-04-2451","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.abb.2011.10.020","article-title":"E-cadherin cell-cell communication in melanogenesis and during development of malignant melanoma","volume":"524","author":"Kuphal","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"key20180107210926_b10-or-35-04-2451","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1074\/jbc.275.4.2727","article-title":"Methylation patterns of the E-cadherin 5\u2032 CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression","volume":"275","author":"Graff","year":"2000","journal-title":"J Biol Chem"},{"key":"key20180107210926_b11-or-35-04-2451","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tiv.2014.10.020","article-title":"Epigenetic marks responsible for cadmium-induced melanoma cell overgrowth","volume":"29","author":"Venza","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"key20180107210926_b12-or-35-04-2451","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.intimp.2015.06.024","article-title":"The overriding of TRAIL resistance by the histone deacetylase inhibitor MS-275 involves c-myc up-regulation in cutaneous, uveal, and mucosal melanoma","volume":"28","author":"Venza","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"key20180107210926_b13-or-35-04-2451","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107210926_b14-or-35-04-2451","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/mc.10064","article-title":"CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancer","volume":"34","author":"Ribeiro-Filho","year":"2002","journal-title":"Mol Carcinog"},{"key":"key20180107210926_b15-or-35-04-2451","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0092-8674(91)90143-M","article-title":"Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role","volume":"66","author":"Vleminckx","year":"1991","journal-title":"Cell"},{"key":"key20180107210926_b16-or-35-04-2451","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/S0002-9440(10)65023-7","article-title":"E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors","volume":"156","author":"Hsu","year":"2000","journal-title":"Am J Pathol"},{"key":"key20180107210926_b17-or-35-04-2451","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/pcmr.12379","article-title":"miR-200c\/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment","volume":"28","author":"Liu","year":"2015","journal-title":"Pigment Cell Melanoma Res"},{"key":"key20180107210926_b18-or-35-04-2451","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/bjd.12426","article-title":"E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression","volume":"169","author":"Lade-Keller","year":"2013","journal-title":"Br J Dermatol"},{"key":"key20180107210926_b19-or-35-04-2451","first-page":"204","article-title":"Impact of E-cadherin expression pattern in melanocytic nevi and cutaneous malignant melanoma","volume":"34","author":"Seleit","year":"2012","journal-title":"Anal Quant Cytopathol Histpathol"},{"key":"key20180107210926_b20-or-35-04-2451","first-page":"1415","article-title":"Epigenetic silencing of E- and P-cadherin gene expression in human melanoma cell lines","volume":"25","author":"Tsutsumida","year":"2004","journal-title":"Int J Oncol"},{"key":"key20180107210926_b21-or-35-04-2451","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1023\/A:1006304806799","article-title":"Cell adhesion molecules in the development and progression of malignant melanoma","volume":"18","author":"Johnson","year":"1999","journal-title":"Cancer Metastasis Rev"},{"key":"key20180107210926_b22-or-35-04-2451","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3892\/etm_00000082","article-title":"Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma","volume":"1","author":"Qiu","year":"2010","journal-title":"Exp Ther Med"},{"key":"key20180107210926_b23-or-35-04-2451","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1128\/MCB.25.11.4727-4741.2005","article-title":"5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal","volume":"25","author":"Ghoshal","year":"2005","journal-title":"Mol Cell Biol"},{"key":"key20180107210926_b24-or-35-04-2451","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1128\/MCB.01799-07","article-title":"DNA methylation inhibitor 5-Aza-2\u2032-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B","volume":"28","author":"Palii","year":"2008","journal-title":"Mol Cell Biol"},{"key":"key20180107210926_b25-or-35-04-2451","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00008390-199604000-00007","article-title":"E-cadherin expression in human melanoma","volume":"6","author":"Danen","year":"1996","journal-title":"Melanoma Res"},{"key":"key20180107210926_b26-or-35-04-2451","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1242\/jcs.113.9.1535","article-title":"Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression","volume":"113","author":"Hsu","year":"2000","journal-title":"J Cell Sci"},{"key":"key20180107210926_b27-or-35-04-2451","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1535-6108(03)00304-0","article-title":"Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion","volume":"4","author":"Lu","year":"2003","journal-title":"Cancer Cell"},{"key":"key20180107210926_b28-or-35-04-2451","first-page":"614","article-title":"Valproic acid inhibits prostate cancer cell migration by up-regulating E-cadherin expression","volume":"66","author":"Zhang","year":"2011","journal-title":"Pharmazie"},{"key":"key20180107210926_b29-or-35-04-2451","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/ijc.22646","article-title":"Involvement of PPAR gamma and E-cadherin\/beta-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cells","volume":"121","author":"Bocca","year":"2007","journal-title":"Int J Cancer"},{"key":"key20180107210926_b30-or-35-04-2451","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cps.2009.08.005","article-title":"Head and neck melanoma","volume":"37","author":"Larson","year":"2010","journal-title":"Clin Plast Surg"},{"key":"key20180107210926_b31-or-35-04-2451","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/jnci\/95.11.806","article-title":"Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma","volume":"95","author":"Whiteman","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"key20180107210926_b32-or-35-04-2451","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1093\/jnci\/djg123","article-title":"Determinants of BRAF mutations in primary melanomas","volume":"95","author":"Maldonado","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"key20180107210926_b33-or-35-04-2451","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1755-148X.2008.00484.x","article-title":"Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling","volume":"21","author":"Liu","year":"2008","journal-title":"Pigment Cell Melanoma Res"},{"key":"key20180107210926_b34-or-35-04-2451","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.oooo.2015.06.038","article-title":"Mucosal melanoma of the head and neck: Recurrence characteristics and survival outcomes","volume":"120","author":"Bakkal","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"key20180107210926_b35-or-35-04-2451","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/CMR.0b013e3283470ffd","article-title":"Review: Mucosal melanoma of the head and neck","volume":"21","author":"Gavriel","year":"2011","journal-title":"Melanoma Res"},{"key":"key20180107210926_b36-or-35-04-2451","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/CMR.0b013e3283005270","article-title":"Prognostic biomarkers in uveal melanoma: Evidence for a stem cell-like phenotype associated with metastasis","volume":"18","author":"Chang","year":"2008","journal-title":"Melanoma Res"},{"key":"key20180107210926_b37-or-35-04-2451","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/j.1365-2133.2007.08246.x","article-title":"Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma","volume":"157","author":"Tucci","year":"2007","journal-title":"Br J Dermatol"},{"key":"key20180107210926_b38-or-35-04-2451","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI36183","article-title":"Biomarkers for epithelial-mesenchymal transitions","volume":"119","author":"Zeisberg","year":"2009","journal-title":"J Clin Invest"},{"key":"key20180107210926_b39-or-35-04-2451","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1593\/neo.08968","article-title":"Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells","volume":"10","author":"Li","year":"2008","journal-title":"Neoplasia"},{"key":"key20180107210926_b40-or-35-04-2451","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/bjc.2015.358","article-title":"Interplay between cadherins and \u03b12\u03b21 integrin differentially regulates melanoma cell invasion","volume":"113","author":"Siret","year":"2015","journal-title":"Br J Cancer"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.4618\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T22:58:16Z","timestamp":1654297096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.4618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,2,11]]},"published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.3892\/or.2016.4618"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.4618","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}