{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:58:37Z","timestamp":1781071117689,"version":"3.54.1"},"reference-count":52,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.3892\/or.2016.4656","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T10:02:39Z","timestamp":1457344959000},"page":"2896-2906","source":"Crossref","is-referenced-by-count":16,"title":["Effect of brefeldin A and castanospermine on resistant cell lines as supplements in anticancer therapy"],"prefix":"10.3892","volume":"35","author":[{"given":"KAROLINA","family":"WOJTOWICZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RADOS\u0141AW","family":"JANUCHOWSKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRYCJA","family":"SOSI\u0143SKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MICHA\u0141","family":"NOWICKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MACIEJ","family":"ZABEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,3,7]]},"reference":[{"key":"key20180107211002_b1-or-35-05-2896","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/pmic.201300387","article-title":"Cell surface protein glycosylation in cancer","volume":"14","author":"Christiansen","year":"2014","journal-title":"Proteomics"},{"issue":"Suppl","key":"key20180107211002_b2-or-35-05-2896","first-page":"IT18","article-title":"Cancer multidrug resistance","volume":"18","author":"Persidis","year":"2000","journal-title":"Nat Biotechnol"},{"key":"key20180107211002_b3-or-35-05-2896","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2217\/14622416.9.1.105","article-title":"ABC multidrug transporters: Structure, function and role in chemoresistance","volume":"9","author":"Sharom","year":"2008","journal-title":"Pharmacogenomics"},{"key":"key20180107211002_b4-or-35-05-2896","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/iub.1133","article-title":"Functional roles of glycogene and n-glycan in multidrug resistance of human breast cancer cells","volume":"65","author":"Ma","year":"2013","journal-title":"IUBMB Life"},{"key":"key20180107211002_b5-or-35-05-2896","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jprot.2013.02.021","article-title":"In-depth research of multidrug resistance related cell surface glycoproteome in gastric cancer","volume":"82","author":"Li","year":"2013","journal-title":"J Proteomics"},{"key":"key20180107211002_b6-or-35-05-2896","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/1097-0215(20000901)87:5<615::AID-IJC1>3.0.CO;2-4","article-title":"Intracellular P-glycoprotein expression is associated with the intrinsic multidrug resistance phenotype in human colon adenocarcinoma cells","volume":"87","author":"Meschini","year":"2000","journal-title":"Int J Cancer"},{"key":"key20180107211002_b7-or-35-05-2896","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJM198705283162207","article-title":"Multiple-drug resistance in human cancer","volume":"316","author":"Pastan","year":"1987","journal-title":"N Engl J Med"},{"key":"key20180107211002_b8-or-35-05-2896","doi-asserted-by":"crossref","first-page":"445","DOI":"10.18388\/abp.2012_2076","article-title":"Inhibitors of N-glycosylation as a potential tool for analysis of the mechanism of action and cellular localisation of glycoprotein P","volume":"59","author":"Wojtowicz","year":"2012","journal-title":"Acta Biochim Pol"},{"key":"key20180107211002_b9-or-35-05-2896","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/(SICI)1097-0215(19980610)76:6<857::AID-IJC15>3.0.CO;2-#","article-title":"Functional intracellular P-glycoprotein","volume":"76","author":"Shapiro","year":"1998","journal-title":"Int J Cancer"},{"key":"key20180107211002_b10-or-35-05-2896","first-page":"226","article-title":"Nuclear immunolocalization of P-glycoprotein in multidrug-resistant cell lines showing similar mechanisms of doxorubicin distribution","volume":"68","author":"Baldini","year":"1995","journal-title":"Eur J Cell Biol"},{"key":"key20180107211002_b11-or-35-05-2896","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1023\/A:1026732405381","article-title":"Detection of P-glycoprotein in the nuclear envelope of multidrug resistant cells","volume":"32","author":"Calcabrini","year":"2000","journal-title":"Histochem J"},{"key":"key20180107211002_b12-or-35-05-2896","first-page":"53","article-title":"Human ABC transporter ABCG2\/BCRP expression in chemoresistance: Basic and clinical perspectives for molecular cancer therapeutics","volume":"7","author":"Noguchi","year":"2014","journal-title":"Pharm Genomics Pers Med"},{"key":"key20180107211002_b13-or-35-05-2896","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5732\/cjc.011.10320","article-title":"Breast cancer resistance protein (BCRP\/ABCG2): Its role in multidrug resistance and regulation of its gene expression","volume":"31","author":"Nakanishi","year":"2012","journal-title":"Chin J Cancer"},{"key":"key20180107211002_b14-or-35-05-2896","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.addr.2008.08.008","article-title":"Quality control of human ABCG2 protein in the endoplasmic reticulum: Ubiquitination and proteasomal degradation","volume":"61","author":"Wakabayashi-Nakao","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"key":"key20180107211002_b15-or-35-05-2896","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.1111\/j.1742-4658.2009.07423.x","article-title":"Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2","volume":"276","author":"Nakagawa","year":"2009","journal-title":"FEBS J"},{"key":"key20180107211002_b16-or-35-05-2896","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1242\/dmm.014589","article-title":"Glycoprotein folding and quality-control mechanisms in protein-folding diseases","volume":"7","author":"Ferris","year":"2014","journal-title":"Dis Model Mech"},{"key":"key20180107211002_b17-or-35-05-2896","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.bcp.2009.11.020","article-title":"N-Glycosylation plays a role in protein folding of human UGT1A9","volume":"79","author":"Nakajima","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"key20180107211002_b18-or-35-05-2896","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.semcdb.2014.12.001","article-title":"N-linked sugar-regulated protein folding and quality control in the ER","volume":"41","author":"Tannous","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"key20180107211002_b19-or-35-05-2896","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.201312042","article-title":"Quality control: ER-associated degradation: protein quality control and beyond","volume":"204","author":"Ruggiano","year":"2014","journal-title":"J Cell Biol"},{"key":"key20180107211002_b20-or-35-05-2896","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.116.5.1071","article-title":"Brefeldin A: Insights into the control of membrane traffic and organelle structure","volume":"116","author":"Klausner","year":"1992","journal-title":"J Cell Biol"},{"key":"key20180107211002_b21-or-35-05-2896","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/bj2650161","article-title":"Brefeldin A arrests the intracellular transport of viral envelope proteins in primary cultured rat hepatocytes and HepG2 cells","volume":"265","author":"Oda","year":"1990","journal-title":"Biochem J"},{"key":"key20180107211002_b22-or-35-05-2896","doi-asserted-by":"crossref","first-page":"11398","DOI":"10.1016\/S0021-9258(18)67398-3","article-title":"Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes","volume":"261","author":"Misumi","year":"1986","journal-title":"J Biol Chem"},{"key":"key20180107211002_b23-or-35-05-2896","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(98)00380-2","article-title":"Brefeldin A-induced apoptosis is expressed in rat neurons with dephosphorylated tau protein","volume":"250","author":"Yardin","year":"1998","journal-title":"Neurosci Lett"},{"key":"key20180107211002_b24-or-35-05-2896","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1159\/000070307","article-title":"Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines","volume":"64","author":"Pommepuy","year":"2003","journal-title":"Oncology"},{"key":"key20180107211002_b25-or-35-05-2896","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/excr.1996.0266","article-title":"Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53","volume":"227","author":"Shao","year":"1996","journal-title":"Exp Cell Res"},{"key":"key20180107211002_b26-or-35-05-2896","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/bcpt.12107","article-title":"Brefeldin A induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits focal adhesion kinase-mediated cell invasion","volume":"113","author":"Lee","year":"2013","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"key20180107211002_b27-or-35-05-2896","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.oraloncology.2003.12.007","article-title":"Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells","volume":"40","author":"Salles","year":"2004","journal-title":"Oral Oncol"},{"key":"key20180107211002_b28-or-35-05-2896","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.leukres.2007.03.008","article-title":"Brefeldin A triggers apoptosis associated with mitochondrial breach and enhances HA14-1- and anti-Fas-mediated cell killing in follicular lymphoma cells","volume":"31","author":"Wlodkowic","year":"2007","journal-title":"Leuk Res"},{"key":"key20180107211002_b29-or-35-05-2896","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0022-5347(05)67323-5","article-title":"Brefeldin A induces p53-independent apoptosis in primary cultures of human prostatic cancer cells","volume":"164","author":"Wallen","year":"2000","journal-title":"J Urol"},{"key":"key20180107211002_b30-or-35-05-2896","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/bjc.1996.103","article-title":"Low-level doxorubicin resistance in P-glycoprotein-negative human pancreatic tumour PSN1\/ADR cells implicates a brefeldin A-sensitive mechanism of drug extrusion","volume":"73","author":"Verovski","year":"1996","journal-title":"Br J Cancer"},{"key":"key20180107211002_b31-or-35-05-2896","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0031-9422(81)85181-3","article-title":"Castanospermine, a 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid from seeds of Castanospermum austarale","volume":"20","author":"Hohenschutz","year":"1981","journal-title":"Phytochemistry"},{"key":"key20180107211002_b32-or-35-05-2896","first-page":"2920","article-title":"The \u03b1-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth","volume":"55","author":"Pili","year":"1995","journal-title":"Cancer Res"},{"key":"key20180107211002_b33-or-35-05-2896","first-page":"355","article-title":"Synergism of castanospermine and FK 506","volume":"27","author":"Grochowicz","year":"1995","journal-title":"Transplant Proc"},{"key":"key20180107211002_b34-or-35-05-2896","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1055\/s-2006-957384","article-title":"Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection","volume":"64","author":"Vlietinck","year":"1998","journal-title":"Planta Med"},{"key":"key20180107211002_b35-or-35-05-2896","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.antiviral.2013.06.011","article-title":"Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions","volume":"99","author":"Chang","year":"2013","journal-title":"Antiviral Res"},{"key":"key20180107211002_b36-or-35-05-2896","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.phytochem.2014.12.011","article-title":"Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors","volume":"111","author":"Kato","year":"2015","journal-title":"Phytochemistry"},{"key":"key20180107211002_b37-or-35-05-2896","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0300-9084(03)00018-X","article-title":"Role of oligomannosidic N-glycans in the proliferation, adhesion and signalling of C6 glioblastoma cells","volume":"85","author":"Schraen-Maschke","year":"2003","journal-title":"Biochimie"},{"key":"key20180107211002_b38-or-35-05-2896","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biopha.2015.07.001","article-title":"Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines","volume":"74","author":"Wojtowicz","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"key20180107211002_b39-or-35-05-2896","doi-asserted-by":"crossref","first-page":"241763","DOI":"10.1155\/2013\/241763","article-title":"MDR gene expression analysis of six drug-resistant ovarian cancer cell lines","volume":"2013","author":"Januchowski","year":"2013","journal-title":"BioMed Res Int"},{"key":"key20180107211002_b40-or-35-05-2896","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.biopha.2013.03.011","article-title":"Nuclear localization of P-glycoprotein is responsible for protection of the nucleus from doxorubicin in the resistant LoVo cell line","volume":"67","author":"Szaflarski","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"key20180107211002_b41-or-35-05-2896","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/ijc.11659","article-title":"Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: Implications in multidrug resistance in cancer","volume":"109","author":"Fu","year":"2004","journal-title":"Int J Cancer"},{"key":"key20180107211002_b42-or-35-05-2896","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1476-5381.2009.00552.x","article-title":"The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes","volume":"159","author":"Janneh","year":"2010","journal-title":"Br J Pharmacol"},{"key":"key20180107211002_b43-or-35-05-2896","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/bjc.1994.250","article-title":"Modification by brefeldin A, bafilomycin A1 and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole (nBD) of cellular accumulation and intracellular distribution of anthracyclines in the non-P-glycoprotein-mediated multidrug-resistant cell line COR-L23\/R","volume":"70","author":"Rhodes","year":"1994","journal-title":"Br J Cancer"},{"key":"key20180107211002_b44-or-35-05-2896","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3835(96)04368-6","article-title":"Monensin and verapamil do not alter intracellular localisation of daunorubicin in multidrug resistant human KB cells","volume":"108","author":"Wood","year":"1996","journal-title":"Cancer Lett"},{"key":"key20180107211002_b45-or-35-05-2896","first-page":"3157","article-title":"Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: Evidence for nuclear drug accumulation and redistribution in resistant cells","volume":"52","author":"Marquardt","year":"1992","journal-title":"Cancer Res"},{"key":"key20180107211002_b46-or-35-05-2896","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0145-2126(00)00048-5","article-title":"Identification of the subcellular localization of daunorubicin in multidrug-resistant K562 cell line","volume":"24","author":"Gong","year":"2000","journal-title":"Leuk Res"},{"key":"key20180107211002_b47-or-35-05-2896","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00006676-200310000-00004","article-title":"Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of brefeldin-A on the resistant cell line","volume":"27","author":"Togawa","year":"2003","journal-title":"Pancreas"},{"key":"key20180107211002_b48-or-35-05-2896","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/(SICI)1097-0320(19980601)32:2<86::AID-CYTO3>3.0.CO;2-C","article-title":"Cytometric study of intracellular P-gp expression and reversal of drug resistance","volume":"32","author":"Labroille","year":"1998","journal-title":"Cytometry"},{"key":"key20180107211002_b49-or-35-05-2896","doi-asserted-by":"crossref","first-page":"e76411","DOI":"10.1371\/journal.pone.0076411","article-title":"New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells","volume":"8","author":"Allan","year":"2013","journal-title":"PLoS One"},{"key":"key20180107211002_b50-or-35-05-2896","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1038\/sj.leu.2402647","article-title":"Lack of p53 expression in human myeloid leukemias is not due to mutations in transcriptional regulatory regions of the gene","volume":"16","author":"Durland-Busbice","year":"2002","journal-title":"Leukemia"},{"key":"key20180107211002_b51-or-35-05-2896","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.201009059","article-title":"p53 and its mutants in tumor cell migration and invasion","volume":"192","author":"Muller","year":"2011","journal-title":"J Cell Biol"},{"key":"key20180107211002_b52-or-35-05-2896","first-page":"3059","article-title":"Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: Involvement of NF-kappaB activation in drug resistance","volume":"58","author":"Lin","year":"1998","journal-title":"Cancer Res"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.4656\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T21:03:04Z","timestamp":1718398984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.4656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,7]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,3,7]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.3892\/or.2016.4656"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.4656","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,7]]}}}