{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:47:12Z","timestamp":1791499632128,"version":"4.3.4"},"reference-count":31,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.3892\/or.2016.4690","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T09:39:00Z","timestamp":1458207540000},"page":"3075-3083","source":"Crossref","is-referenced-by-count":95,"title":["Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway"],"prefix":"10.3892","volume":"35","author":[{"given":"RUIXUAN","family":"WANG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIJIE","family":"MA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAN","family":"WENG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIAHUI","family":"YAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XUEYING","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FAGUANG","family":"JIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"key20180107211058_b1-or-35-05-3075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"key20180107211058_b2-or-35-05-3075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4065\/83.3.355","article-title":"Small cell lung cancer","volume":"83","author":"Sher","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"key20180107211058_b3-or-35-05-3075","first-page":"CD001990","article-title":"Chemotherapy versus best supportive care for extensive small cell lung cancer","volume":"11","author":"Pelayo Alvarez","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"key20180107211058_b4-or-35-05-3075","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1634\/theoncologist.12-9-1096","article-title":"Small cell lung cancer: Have we made any progress over the last 25 years?","volume":"12","author":"Lally","year":"2007","journal-title":"Oncologist"},{"key":"key20180107211058_b5-or-35-05-3075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yexcr.2015.05.012","article-title":"Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells","volume":"336","author":"Tyler","year":"2015","journal-title":"Exp Cell Res"},{"key":"key20180107211058_b6-or-35-05-3075","doi-asserted-by":"crossref","first-page":"896751","DOI":"10.1155\/2012\/896751","article-title":"Mitochondria: Redox metabolism and dysfunction","volume":"2012","author":"Kang","year":"2012","journal-title":"Biochem Res Int"},{"key":"key20180107211058_b7-or-35-05-3075","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0378-4274(95)03474-9","article-title":"Signalling mechanisms and oxidative stress in apoptosis","volume":"82\u201383","author":"Slater","year":"1995","journal-title":"Toxicol Lett"},{"key":"key20180107211058_b8-or-35-05-3075","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00204-012-0906-3","article-title":"Oxidative stress in apoptosis and cancer: An update","volume":"86","author":"Mat\u00e9s","year":"2012","journal-title":"Arch Toxicol"},{"key":"key20180107211058_b9-or-35-05-3075","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1371\/journal.pbio.0050206","article-title":"Mitochondrial cell death control in familial Parkinson disease","volume":"5","author":"Kroemer","year":"2007","journal-title":"PLoS Biol"},{"key":"key20180107211058_b10-or-35-05-3075","doi-asserted-by":"crossref","first-page":"403870","DOI":"10.1155\/2012\/403870","article-title":"Reactive oxygen species-mediated control of mitochondrial biogenesis","volume":"2012","author":"Yoboue","year":"2012","journal-title":"Int J Cell Biol"},{"key":"key20180107211058_b11-or-35-05-3075","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1158\/1078-0432.CCR-06-2082","article-title":"Reactive oxygen species: A breath of life or death?","volume":"13","author":"Fruehauf","year":"2007","journal-title":"Clin Cancer Res"},{"key":"key20180107211058_b12-or-35-05-3075","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/jn\/131.4.1207","article-title":"Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans","volume":"131","author":"Shahrzad","year":"2001","journal-title":"J Nutr"},{"key":"key20180107211058_b13-or-35-05-3075","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ptr.3602","article-title":"Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid","volume":"26","author":"Oi","year":"2012","journal-title":"Phytother Res"},{"key":"key20180107211058_b14-or-35-05-3075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.foodchem.2012.08.009","article-title":"Toona sinensis and its major bioactive compound gallic acid inhibit LPS-induced inflammation in nuclear factor-\u03baB transgenic mice as evaluated by in vivo bioluminescence imaging","volume":"136","author":"Hsiang","year":"2013","journal-title":"Food Chem"},{"key":"key20180107211058_b15-or-35-05-3075","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1021\/jf9043265","article-title":"Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway","volume":"58","author":"Chuang","year":"2010","journal-title":"J Agric Food Chem"},{"key":"key20180107211058_b16-or-35-05-3075","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1021\/jf103379d","article-title":"The effects of mitogen-activated protein kinase inhibitors or small interfering RNAs on gallic acid-induced HeLa cell death in relation to reactive oxygen species and glutathione","volume":"59","author":"You","year":"2011","journal-title":"J Agric Food Chem"},{"key":"key20180107211058_b17-or-35-05-3075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11010-011-0900-8","article-title":"Gallic acid-induced lung cancer cell death is accompanied by ROS increase and glutathione depletion","volume":"357","author":"You","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"key20180107211058_b18-or-35-05-3075","doi-asserted-by":"crossref","first-page":"8377","DOI":"10.3390\/molecules15118377","article-title":"Anti-neoplastic effects of gallic acid, a major component of Toona sinensis leaf extract, on oral squamous carcinoma cells","volume":"15","author":"Chia","year":"2010","journal-title":"Molecules"},{"key":"key20180107211058_b19-or-35-05-3075","first-page":"1595","article-title":"Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells","volume":"32","author":"Russell","year":"2012","journal-title":"Anticancer Res"},{"key":"key20180107211058_b20-or-35-05-3075","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1200\/JCO.2005.04.4859","article-title":"Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database","volume":"24","author":"Govindan","year":"2006","journal-title":"J Clin Oncol"},{"key":"key20180107211058_b21-or-35-05-3075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000063807","article-title":"Small cell lung cancer: Defining a role for emerging platinum drugs","volume":"63","author":"Schiller","year":"2002","journal-title":"Oncology"},{"key":"key20180107211058_b22-or-35-05-3075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4161\/cbt.9.1.10392","article-title":"Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer","volume":"9","author":"Bayet-Robert","year":"2010","journal-title":"Cancer Biol Ther"},{"key":"key20180107211058_b23-or-35-05-3075","first-page":"573","article-title":"Why target apoptosis in cancer treatment?","volume":"2","author":"Kasibhatla","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"key20180107211058_b24-or-35-05-3075","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.bcp.2011.07.093","article-title":"Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications","volume":"82","author":"Singh","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"key20180107211058_b25-or-35-05-3075","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1038\/sj.onc.1203249","article-title":"More than one way to die: Apoptosis, necrosis and reactive oxygen damage","volume":"18","author":"Fiers","year":"1999","journal-title":"Oncogene"},{"key":"key20180107211058_b26-or-35-05-3075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2014.04.007","article-title":"Adenosine induces apoptosis in human liver cancer cells through ROS production and mitochondrial dysfunction","volume":"448","author":"Ma","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107211058_b27-or-35-05-3075","first-page":"647","article-title":"Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by hematopoietic cytokines and dexamethasone","volume":"6","author":"Lotem","year":"1995","journal-title":"Cell Growth Differ"},{"key":"key20180107211058_b28-or-35-05-3075","doi-asserted-by":"crossref","first-page":"e107045","DOI":"10.1371\/journal.pone.0107045","article-title":"Grape seed proanthocyanidins (GSPs) inhibit the growth of cervical cancer by inducing apoptosis mediated by the mitochondrial pathway","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"key20180107211058_b29-or-35-05-3075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(00)00009-X","article-title":"Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins","volume":"102","author":"Verhagen","year":"2000","journal-title":"Cell"},{"key":"key20180107211058_b30-or-35-05-3075","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.3390\/md11061961","article-title":"Fucoidan derived from Undaria pinnatifida induces apoptosis in human hepatocellular carcinoma SMMC-7721 cells via the ROS-mediated mitochondrial pathway","volume":"11","author":"Yang","year":"2013","journal-title":"Mar Drugs"},{"key":"key20180107211058_b31-or-35-05-3075","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/CAD.0b013e328362469f","article-title":"OSU-03012, a non-Cox inhibiting celecoxib derivative, induces apoptosis of human esophageal carcinoma cells through a p53\/Bax\/cytochrome c\/caspase-9-dependent pathway","volume":"24","author":"Liu","year":"2013","journal-title":"Anticancer Drugs"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.4690\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T12:57:34Z","timestamp":1567688254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.4690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,3,17]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.3892\/or.2016.4690"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.4690","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}