{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:10:39Z","timestamp":1791688239375,"version":"4.3.4"},"reference-count":45,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3892\/or.2016.4717","type":"journal-article","created":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T13:53:22Z","timestamp":1459259602000},"page":"3241-3247","source":"Crossref","is-referenced-by-count":3,"title":["Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice"],"prefix":"10.3892","volume":"35","author":[{"given":"TAKASHI","family":"OHNO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MASAHIRO","family":"OHTANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIROYUKI","family":"SUTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAKOTO","family":"OHTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOSHIAKI","family":"IMAMURA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HIDETAKA","family":"MATSUDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATSUSHI","family":"HIRAMATSU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TOMOYUKI","family":"NEMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YASUNARI","family":"NAKAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"key20180107211652_b1-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.ejca.2014.01.029","article-title":"Worldwide trends in gastric cancer mortality (1980\u20132011), with predictions to 2015, and incidence by subtype","volume":"50","author":"Ferro","year":"2014","journal-title":"Eur J Cancer"},{"key":"key20180107211652_b2-or-35-06-3241","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"key20180107211652_b3-or-35-06-3241","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.ejca.2010.07.025","article-title":"Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study","volume":"46","author":"Gonzalez","year":"2010","journal-title":"Eur J Cancer"},{"key":"key20180107211652_b4-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1248\/bpb.22.1388","article-title":"Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)","volume":"22","author":"Shiota","year":"1999","journal-title":"Biol Pharm Bull"},{"key":"key20180107211652_b5-or-35-06-3241","first-page":"563","article-title":"Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats","volume":"38","author":"El-Beshbishy","year":"2005","journal-title":"J Biochem Mol Biol"},{"key":"key20180107211652_b6-or-35-06-3241","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1021\/jf903377e","article-title":"Indoleamine 2,3-dioxy-genase, an immunomodulatory protein, is suppressed by (\u2013)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells","volume":"58","author":"Cheng","year":"2010","journal-title":"J Agric Food Chem"},{"key":"key20180107211652_b7-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1349-7006.1988.tb01528.x","article-title":"A case-control study of gastric cancer and diet in northern Kyushu, Japan","volume":"79","author":"Kono","year":"1988","journal-title":"Jpn J Cancer Res"},{"key":"key20180107211652_b8-or-35-06-3241","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1002\/(SICI)1097-0142(19960615)77:12<2449::AID-CNCR6>3.0.CO;2-H","article-title":"The influence of cigarette smoking, alcohol, and green tea consumption on the risk of carcinoma of the cardia and distal stomach in Shanghai, China","volume":"77","author":"Ji","year":"1996","journal-title":"Cancer"},{"key":"key20180107211652_b9-or-35-06-3241","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1008890529261","article-title":"Tea and coffee consumption and the risk of digestive tract cancers: Data from a comparative case-referent study in Japan","volume":"9","author":"Inoue","year":"1998","journal-title":"Cancer Causes Control"},{"key":"key20180107211652_b10-or-35-06-3241","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1056\/NEJM200103013440903","article-title":"Green tea and the risk of gastric cancer in Japan","volume":"344","author":"Tsubono","year":"2001","journal-title":"N Engl J Med"},{"key":"key20180107211652_b11-or-35-06-3241","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1023\/A:1011297326696","article-title":"A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan)","volume":"12","author":"Nagano","year":"2001","journal-title":"Cancer Causes Control"},{"key":"key20180107211652_b12-or-35-06-3241","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/sj.bjc.6600487","article-title":"A prospective study of stomach cancer death in relation to green tea consumption in Japan","volume":"87","author":"Hoshiyama","year":"2002","journal-title":"Br J Cancer"},{"key":"key20180107211652_b13-or-35-06-3241","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.taap.2013.09.021","article-title":"Green tea polyphenol, (\u2013)-epigallo-catechin-3-gallate, induces toxicity in human skin cancer cells by targeting \u03b2-catenin signaling","volume":"273","author":"Singh","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20180107211652_b14-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/carcin\/bgr218","article-title":"Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1\u03b1","volume":"32","author":"Wang","year":"2011","journal-title":"Carcinogenesis"},{"key":"key20180107211652_b15-or-35-06-3241","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1093\/carcin\/bgh255","article-title":"Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells","volume":"25","author":"Baek","year":"2004","journal-title":"Carcinogenesis"},{"key":"key20180107211652_b16-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1002\/pros.20643","article-title":"Epigallocatechin-3-gallate suppresses early stage, but not late stage prostate cancer in TRAMP mice: Mechanisms of action","volume":"67","author":"Harper","year":"2007","journal-title":"Prostate"},{"key":"key20180107211652_b17-or-35-06-3241","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1006\/abbi.2000.1742","article-title":"Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells","volume":"376","author":"Ahmad","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"key20180107211652_b18-or-35-06-3241","first-page":"4414","article-title":"Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (\u2013)-epigallocatechin gallate, and theaflavins","volume":"57","author":"Dong","year":"1997","journal-title":"Cancer Res"},{"key":"key20180107211652_b19-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/carcin\/bgp166","article-title":"(\u2013)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046\/1047 by p38 MAPK in colon cancer cells","volume":"30","author":"Adachi","year":"2009","journal-title":"Carcinogenesis"},{"key":"key20180107211652_b20-or-35-06-3241","first-page":"2081","article-title":"Inhibition of N-methyl-N\u2032-nitro-N-nitrosoguanidine-induced carcinogenesis by (\u2013)-epigallocatechin gallate in the rat glandular stomach","volume":"55","author":"Yamane","year":"1995","journal-title":"Cancer Res"},{"key":"key20180107211652_b21-or-35-06-3241","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/carcin\/14.5.849","article-title":"Protection against N-nitrosodiethylamine and benzo[a]pyrene-induced forestomach and lung tumorigenesis in A\/J mice by green tea","volume":"14","author":"Katiyar","year":"1993","journal-title":"Carcinogenesis"},{"key":"key20180107211652_b22-or-35-06-3241","first-page":"6735","article-title":"Human gastric carcinogenesis: A multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa","year":"1992","journal-title":"Cancer Res"},{"key":"key20180107211652_b23-or-35-06-3241","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0016-5085(00)70412-4","article-title":"Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer","volume":"118","author":"Wang","year":"2000","journal-title":"Gastroenterology"},{"key":"key20180107211652_b24-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0016-5085(03)00406-2","article-title":"Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia","volume":"124","author":"Fox","year":"2003","journal-title":"Gastroenterology"},{"key":"key20180107211652_b25-or-35-06-3241","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1158\/0008-5472.CAN-05-1846","article-title":"Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice","volume":"65","author":"Rogers","year":"2005","journal-title":"Cancer Res"},{"key":"key20180107211652_b26-or-35-06-3241","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/carcin\/bgm150","article-title":"Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice","volume":"28","author":"Ohtani","year":"2007","journal-title":"Carcinogenesis"},{"key":"key20180107211652_b27-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1053\/j.gastro.2005.03.027","article-title":"Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer","volume":"128","author":"Takaishi","year":"2005","journal-title":"Gastroenterology"},{"key":"key20180107211652_b28-or-35-06-3241","first-page":"481","article-title":"Effects of green tea on growth, food utilization and lipid metabolism in mice","volume":"14","author":"Sayama","year":"2000","journal-title":"In Vivo"},{"key":"key20180107211652_b29-or-35-06-3241","doi-asserted-by":"crossref","first-page":"520510","DOI":"10.1155\/2012\/520510","article-title":"Catechins and caffeine inhibit fat accumulation in mice through the improvement of hepatic lipid metabolism","volume":"2012","author":"Sugiura","year":"2012","journal-title":"J Obes"},{"key":"key20180107211652_b30-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/ptr.2737","article-title":"Inhibitory effects of green tea catechin on the lipid accumulation in 3T3-L1 adipocytes","volume":"23","author":"Lee","year":"2009","journal-title":"Phytother Res"},{"key":"key20180107211652_b31-or-35-06-3241","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/sj.ijo.0803135","article-title":"Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimming","volume":"30","author":"Murase","year":"2006","journal-title":"Int J Obes"},{"key":"key20180107211652_b32-or-35-06-3241","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s005350200004","article-title":"The protective effect of catechin on gastric mucosal lesions in rats, and its hormonal mechanisms","volume":"37","author":"Sato","year":"2002","journal-title":"J Gastroenterol"},{"key":"key20180107211652_b33-or-35-06-3241","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.4049\/jimmunol.0803293","article-title":"The CD4+ T cell-mediated IFN-gamma response to Helicobacter infection is essential for clearance and determines gastric cancer risk","volume":"182","author":"Sayi","year":"2009","journal-title":"J Immunol"},{"key":"key20180107211652_b34-or-35-06-3241","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3835(03)00342-2","article-title":"Enhancement by interleukin-1 beta of gastric carcinogenesis induced by N-methyl-N\u2032-nitro-N-nitrosoguanidine in Wistar rats: A possible mechanism for Helicobacter pylori-associated gastric carcinogenesis","volume":"198","author":"Uedo","year":"2003","journal-title":"Cancer Lett"},{"key":"key20180107211652_b35-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.165.2.1022","article-title":"Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice","volume":"165","author":"Smythies","year":"2000","journal-title":"J Immunol"},{"key":"key20180107211652_b36-or-35-06-3241","first-page":"355","article-title":"EGCG and polyphenon E attenuate inflammation-related mouse colon carcinogenesis induced by AOM plus DDS","volume":"1","author":"Shirakami","year":"2008","journal-title":"Mol Med Rep"},{"key":"key20180107211652_b37-or-35-06-3241","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1073\/pnas.96.8.4524","article-title":"Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea","volume":"96","author":"Haqqi","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107211652_b38-or-35-06-3241","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2249.2006.03137.x","article-title":"(\u2013)-Epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune-mediated liver injury","volume":"145","author":"Wang","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"key20180107211652_b39-or-35-06-3241","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bbrc.2011.09.115","article-title":"Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1\u03b2 secretion","volume":"414","author":"Ellis","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107211652_b40-or-35-06-3241","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0027-5107(97)00310-2","article-title":"Cancer inhibition by green tea","volume":"402","author":"Fujiki","year":"1998","journal-title":"Mutat Res"},{"key":"key20180107211652_b41-or-35-06-3241","first-page":"1301","article-title":"Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D","volume":"21","author":"Deguchi","year":"2002","journal-title":"Int J Oncol"},{"key":"key20180107211652_b42-or-35-06-3241","first-page":"5325","article-title":"Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells","volume":"33","author":"Moseley","year":"2013","journal-title":"Anticancer Res"},{"key":"key20180107211652_b43-or-35-06-3241","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.2741\/2446","article-title":"Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer","volume":"12","author":"Shankar","year":"2007","journal-title":"Front Biosci"},{"key":"key20180107211652_b44-or-35-06-3241","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3892\/ijo.2013.2043","article-title":"Regulation of Id1 expression by epigallocatechin-3-gallate and its effect on the proliferation and apoptosis of poorly differentiated AGS gastric cancer cells","volume":"43","author":"Ma","year":"2013","journal-title":"Int J Oncol"},{"key":"key20180107211652_b45-or-35-06-3241","first-page":"1403","article-title":"(\u2013)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression","volume":"38","author":"Onoda","year":"2011","journal-title":"Int J Oncol"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.4717\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T21:17:04Z","timestamp":1515359824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.4717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,29]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,3,29]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.3892\/or.2016.4717"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.4717","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,29]]}}}