{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:51:15Z","timestamp":1785336675282,"version":"3.55.0"},"reference-count":42,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3892\/or.2016.4729","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T10:27:33Z","timestamp":1459765653000},"page":"3586-3592","source":"Crossref","is-referenced-by-count":36,"title":["LSD1-mediated epigenetic modification contributes to ovarian cancer cell migration and invasion"],"prefix":"10.3892","volume":"35","author":[{"given":"YUANXIA","family":"LI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAOLEI","family":"WAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YE","family":"WEI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIUWEN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WENSHENG","family":"LAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LIUPING","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIE","family":"JIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHAOYANG","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QIXIANG","family":"SHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GENBAO","family":"SHAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QIONG","family":"LIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"key20180107211627_b1-or-35-06-3586","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J Clin"},{"key":"key20180107211627_b2-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(09)61338-6","article-title":"Ovarian cancer","volume":"374","author":"Hennessy","year":"2009","journal-title":"Lancet"},{"key":"key20180107211627_b3-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"key20180107211627_b4-or-35-06-3586","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","article-title":"Histone demethylation mediated by the nuclear amine oxidase homolog LSD1","volume":"119","author":"Shi","year":"2004","journal-title":"Cell"},{"key":"key20180107211627_b5-or-35-06-3586","doi-asserted-by":"crossref","first-page":"e35065","DOI":"10.1371\/journal.pone.0035065","article-title":"Overexpression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer","volume":"7","author":"Lv","year":"2012","journal-title":"PLoS One"},{"key":"key20180107211627_b6-or-35-06-3586","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ijc.25349","article-title":"Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers","volume":"128","author":"Hayami","year":"2011","journal-title":"Int J Cancer"},{"key":"key20180107211627_b7-or-35-06-3586","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1472-6890-12-13","article-title":"Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast","volume":"12","author":"Serce","year":"2012","journal-title":"BMC Clin Pathol"},{"key":"key20180107211627_b8-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/ijc.27343","article-title":"Cryptotanshinone down-regulates androgen receptor signaling by modulating lysine-specific demethylase 1 function","volume":"131","author":"Wu","year":"2012","journal-title":"Int J Cancer"},{"key":"key20180107211627_b9-or-35-06-3586","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1158\/0008-5472.CAN-06-1570","article-title":"Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence","volume":"66","author":"Kahl","year":"2006","journal-title":"Cancer Res"},{"key":"key20180107211627_b10-or-35-06-3586","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.3748\/wjg.v18.i45.6651","article-title":"Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients","volume":"18","author":"Zhao","year":"2012","journal-title":"World J Gastroenterol"},{"key":"key20180107211627_b11-or-35-06-3586","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/bjc.2013.364","article-title":"LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer","volume":"109","author":"Ding","year":"2013","journal-title":"Br J Cancer"},{"key":"key20180107211627_b12-or-35-06-3586","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbrc.2013.05.123","article-title":"High expression of lysine-specific demethylase 1 correlates with poor prognosis of patients with esophageal squamous cell carcinoma","volume":"437","author":"Yu","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key20180107211627_b13-or-35-06-3586","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1757-2215-6-75","article-title":"Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines","volume":"6","author":"Konovalov","year":"2013","journal-title":"J Ovarian Res"},{"key":"key20180107211627_b14-or-35-06-3586","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13048-015-0155-1","article-title":"Expression of lysine-specific demethylase 1 in human epithelial ovarian cancer","volume":"8","author":"Chen","year":"2015","journal-title":"J Ovarian Res"},{"key":"key20180107211627_b15-or-35-06-3586","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000147748","article-title":"An overview of epithelio-mesenchymal transformation","volume":"154","author":"Hay","year":"1995","journal-title":"Acta Anat (Basel)"},{"key":"key20180107211627_b16-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0006-2952(00)00427-5","article-title":"Induction and regulation of epithelial-mesenchymal transitions","volume":"60","author":"Boyer","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"key20180107211627_b17-or-35-06-3586","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial-mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"key20180107211627_b18-or-35-06-3586","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1242\/jcs.114.4.625","article-title":"The cadherin superfamily","volume":"114","author":"Angst","year":"2001","journal-title":"J Cell Sci"},{"key":"key20180107211627_b19-or-35-06-3586","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1196\/annals.1294.016","article-title":"Cadherin switch in tumor progression","volume":"1014","author":"Hazan","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"key20180107211627_b20-or-35-06-3586","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/32433","article-title":"A causal role for E-cadherin in the transition from adenoma to carcinoma","volume":"392","author":"Perl","year":"1998","journal-title":"Nature"},{"key":"key20180107211627_b21-or-35-06-3586","first-page":"124","article-title":"E-cadherin as an invasion suppressor","volume":"189","author":"Birchmeier","year":"1995","journal-title":"Ciba Foundation Symposium"},{"key":"key20180107211627_b22-or-35-06-3586","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/35000034","article-title":"The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells","volume":"2","author":"Batlle","year":"2000","journal-title":"Nat Cell Biol"},{"key":"key20180107211627_b23-or-35-06-3586","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2004.07.011","article-title":"Epithelial-mesenchymal transitions: twist in development and metastasis","volume":"118","author":"Kang","year":"2004","journal-title":"Cell"},{"key":"key20180107211627_b24-or-35-06-3586","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/sj.bjc.6605543","article-title":"Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12\/Hypo, derived from a scirrhous gastric carcinoma","volume":"102","author":"Kato","year":"2010","journal-title":"Br J Cancer"},{"key":"key20180107211627_b25-or-35-06-3586","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"key20180107211627_b26-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/sj.bjc.6604755","article-title":"Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival","volume":"99","author":"Waldmann","year":"2008","journal-title":"Br J Cancer"},{"key":"key20180107211627_b27-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/emboj.2010.63","article-title":"The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1","volume":"29","author":"Lin","year":"2010","journal-title":"EMBO J"},{"key":"key20180107211627_b28-or-35-06-3586","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1038\/onc.2010.234","article-title":"Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition","volume":"29","author":"Lin","year":"2010","journal-title":"Oncogene"},{"key":"key20180107211627_b29-or-35-06-3586","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1158\/0008-5472.CAN-12-1739","article-title":"Inhibiting interactions of lysine demethylase LSD1 with snail\/slug blocks cancer cell invasion","volume":"73","author":"Ferrari-Amorotti","year":"2013","journal-title":"Cancer Res"},{"key":"key20180107211627_b30-or-35-06-3586","doi-asserted-by":"crossref","first-page":"15344","DOI":"10.1038\/srep15344","article-title":"Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells","volume":"5","author":"Shao","year":"2015","journal-title":"Sci Rep"},{"key":"key20180107211627_b31-or-35-06-3586","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.celrep.2013.09.018","article-title":"Pluripotent stem cell protein Sox2 confers sensitivity to LSD1 inhibition in cancer cells","volume":"5","author":"Zhang","year":"2013","journal-title":"Cell Reports"},{"key":"key20180107211627_b32-or-35-06-3586","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1071\/RD13293","article-title":"Aging alters histone H3 lysine 4 methylation in mouse germinal vesicle stage oocytes","volume":"27","author":"Shao","year":"2015","journal-title":"Reprod Fertil Dev"},{"key":"key20180107211627_b33-or-35-06-3586","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00441-014-1991-9","article-title":"Expression of histone H3 lysine 4 methylation and its demethylases in the developing mouse testis","volume":"358","author":"Zhang","year":"2014","journal-title":"Cell Tissue Res"},{"key":"key20180107211627_b34-or-35-06-3586","doi-asserted-by":"crossref","first-page":"17337","DOI":"10.1073\/pnas.0607015103","article-title":"Small dsRNAs induce transcriptional activation in human cells","volume":"103","author":"Li","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107211627_b35-or-35-06-3586","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng1611","article-title":"Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation","volume":"37","author":"Ting","year":"2005","journal-title":"Nat Genet"},{"key":"key20180107211627_b36-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1128\/MCB.01116-09","article-title":"Histone demethylase LSD1 regulates neural stem cell proliferation","volume":"30","author":"Sun","year":"2010","journal-title":"Mol Cell Biol"},{"key":"key20180107211627_b37-or-35-06-3586","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF03256438","article-title":"Genetic and epigenetic biomarkers in cancer: improving diagnosis, risk assessment, and disease stratification","volume":"10","author":"Verma","year":"2006","journal-title":"Mol Diagn Ther"},{"key":"key20180107211627_b38-or-35-06-3586","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-61779-612-8_15","article-title":"Epigenetics in ovarian cancer","volume":"863","author":"Seeber","year":"2012","journal-title":"Methods Mol Biol"},{"key":"key20180107211627_b39-or-35-06-3586","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/abbs\/gmr109","article-title":"Targeting protein lysine methylation and demethylation in cancers","volume":"44","author":"He","year":"2012","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"key20180107211627_b40-or-35-06-3586","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1615\/CritRevEukarGeneExpr.v22.i1.40","article-title":"Lysine-specific histone demethylase 1 (LSD1): a potential molecular target for tumor therapy","volume":"22","author":"Chen","year":"2012","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"key20180107211627_b41-or-35-06-3586","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/carcin\/bgp324","article-title":"Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology","volume":"31","author":"Lim","year":"2010","journal-title":"Carcinogenesis"},{"key":"key20180107211627_b42-or-35-06-3586","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/MCB.24.1.306-319.2004","article-title":"Snail mediates E-cadherin repression by the recruitment of the Sin3A\/histone deacetylase 1 (HDAC1)\/HDAC2 complex","volume":"24","author":"Peinado","year":"2004","journal-title":"Mol Cell Biol"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.4729\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:59:27Z","timestamp":1655427567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.4729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,4]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,4,4]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.3892\/or.2016.4729"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.4729","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,4]]}}}