{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:52:03Z","timestamp":1784361123715,"version":"3.55.0"},"reference-count":30,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.3892\/or.2016.4750","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T09:54:22Z","timestamp":1460714062000},"page":"3357-3362","source":"Crossref","is-referenced-by-count":10,"title":["Karyopherin \u03b12 induces apoptosis in tongue squamous cell carcinoma CAL-27 cells through the p53 pathway"],"prefix":"10.3892","volume":"35","author":[{"given":"LI","family":"GAO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEI","family":"YU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHUN-MING","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YING","family":"LI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BAO-LIN","family":"JIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BIN","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"key20180107211624_b1-or-35-06-3357","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"key20180107211624_b2-or-35-06-3357","first-page":"12509","article-title":"Adenovirus expressing IFN-\u03bb (Ad\/hIFN-\u03bb) produced anti-tumor effects through inducing apoptosis in human tongue squamous cell carcinoma cell","volume":"8","author":"Song","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"key20180107211624_b3-or-35-06-3357","doi-asserted-by":"crossref","first-page":"39594","DOI":"10.1074\/jbc.M508425200","article-title":"Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1","volume":"280","author":"Tseng","year":"2005","journal-title":"J Biol Chem"},{"key":"key20180107211624_b4-or-35-06-3357","doi-asserted-by":"crossref","first-page":"42346","DOI":"10.1074\/jbc.M303304200","article-title":"Karyopherin-alpha2 protein interacts with Chk2 and contributes to its nuclear import","volume":"278","author":"Zannini","year":"2003","journal-title":"J Biol Chem"},{"key":"key20180107211624_b5-or-35-06-3357","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10735-006-9032-y","article-title":"Importin KPNA2, NBS1, DNA repair and tumorigenesis","volume":"37","author":"Teng","year":"2006","journal-title":"J Mol Histol"},{"key":"key20180107211624_b6-or-35-06-3357","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1158\/1078-0432.CCR-05-2090","article-title":"Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer","volume":"12","author":"Dahl","year":"2006","journal-title":"Clin Cancer Res"},{"key":"key20180107211624_b7-or-35-06-3357","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/jnci\/djj052","article-title":"Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis","volume":"98","author":"Sotiriou","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"key20180107211624_b8-or-35-06-3357","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00428-007-0513-5","article-title":"KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ","volume":"451","author":"Dankof","year":"2007","journal-title":"Virchows Arch"},{"key":"key20180107211624_b9-or-35-06-3357","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/ijc.23628","article-title":"Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity","volume":"123","author":"Gluz","year":"2008","journal-title":"Int J Cancer"},{"key":"key20180107211624_b10-or-35-06-3357","first-page":"851","article-title":"Significance of karyopherin-\u03b1 2 (KPNA2) expression in esophageal squamous cell carcinoma","volume":"30","author":"Sakai","year":"2010","journal-title":"Anticancer Res"},{"key":"key20180107211624_b11-or-35-06-3357","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1002\/ijc.25568","article-title":"Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome","volume":"128","author":"Wang","year":"2011","journal-title":"Int J Cancer"},{"key":"key20180107211624_b12-or-35-06-3357","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1158\/1078-0432.CCR-10-0081","article-title":"KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy","volume":"17","author":"Mortezavi","year":"2011","journal-title":"Clin Cancer Res"},{"key":"key20180107211624_b13-or-35-06-3357","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/onc.2011.403","article-title":"Nuclear transport receptor karyopherin-\u03b12 promotes malignant breast cancer phenotypes in vitro","volume":"31","author":"Noetzel","year":"2012","journal-title":"Oncogene"},{"key":"key20180107211624_b14-or-35-06-3357","doi-asserted-by":"crossref","first-page":"e745","DOI":"10.1038\/cddis.2013.256","article-title":"KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a","volume":"4","author":"Huang","year":"2013","journal-title":"Cell Death Dis"},{"key":"key20180107211624_b15-or-35-06-3357","doi-asserted-by":"crossref","first-page":"703034","DOI":"10.1155\/2012\/703034","article-title":"Jaceosidin induces apoptosis in U87 glioblastoma cells through G2\/M phase arrest","volume":"2012","author":"Khan","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"key20180107211624_b16-or-35-06-3357","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0091-679X(08)61929-9","article-title":"The end of the (cell) line: Methods for the study of apoptosis in vitro","volume":"46","author":"McGahon","year":"1995","journal-title":"Methods Cell Biol"},{"key":"key20180107211624_b17-or-35-06-3357","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.4238\/2015.September.25.10","article-title":"Apoptosis induced by lipid-associated membrane proteins from Mycoplasma hyopneumoniae in a porcine lung epithelial cell line with the involvement of caspase 3 and the MAPK pathway","volume":"14","author":"Ni","year":"2015","journal-title":"Genet Mol Res"},{"key":"key20180107211624_b18-or-35-06-3357","doi-asserted-by":"crossref","first-page":"e0138504","DOI":"10.1371\/journal.pone.0138504","article-title":"E. adenophorum induces cell cycle and apoptosis of renal cells through mitochondrial pathway and caspase activation in Saanen goat","volume":"10","author":"He","year":"2015","journal-title":"PLoS One"},{"key":"key20180107211624_b19-or-35-06-3357","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/AOG.0b013e3181f104ce","article-title":"Overexpression of karyopherin-2 in epithelial ovarian cancer and correlation with poor prognosis","volume":"116","author":"Zheng","year":"2010","journal-title":"Obstet Gynecol"},{"key":"key20180107211624_b20-or-35-06-3357","doi-asserted-by":"crossref","first-page":"e42992","DOI":"10.1371\/journal.pone.0042992","article-title":"Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis","volume":"7","author":"He","year":"2012","journal-title":"PLoS One"},{"key":"key20180107211624_b21-or-35-06-3357","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11060-012-0924-2","article-title":"Nuclear karyopherin a2: A novel biomarker for infiltrative astrocytomas","volume":"109","author":"Gousias","year":"2012","journal-title":"J Neurooncol"},{"key":"key20180107211624_b22-or-35-06-3357","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1142\/S0192415X15500822","article-title":"Chloroform extract of Solanum lyratum induced G0\/G1 arrest via p21\/p16 and induced apoptosis via reactive oxygen species, caspases and mitochondrial pathways in human oral cancer cell lines","volume":"43","author":"Chiu","year":"2015","journal-title":"Am J Chin Med"},{"key":"key20180107211624_b23-or-35-06-3357","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3892\/ijo.2012.1605","article-title":"AKT serine\/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells","volume":"41","author":"Tsai","year":"2012","journal-title":"Int J Oncol"},{"key":"key20180107211624_b24-or-35-06-3357","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jss.2010.07.041","article-title":"Testosterone-down-regulated Akt pathway during cardiac ischemia\/reperfusion: A mechanism involving BAD, Bcl-2 and FOXO3a","volume":"164","author":"Huang","year":"2010","journal-title":"J Surg Res"},{"key":"key20180107211624_b25-or-35-06-3357","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/eji.200838211","article-title":"Interaction with XIAP prevents full caspase-3\/-7 activation in proliferating human T lymphocytes","volume":"38","author":"Paulsen","year":"2008","journal-title":"Eur J Immunol"},{"key":"key20180107211624_b26-or-35-06-3357","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1021\/acs.molpharmaceut.5b00531","article-title":"A novel platinum-maurocalcine conjugate induces apoptosis of human glioblastoma cells by acting through the ROS-ERK\/AKT-p53 pathway","volume":"12","author":"Aroui","year":"2015","journal-title":"Mol Pharm"},{"key":"key20180107211624_b27-or-35-06-3357","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/path.4390","article-title":"KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation","volume":"234","author":"Ikenberg","year":"2014","journal-title":"J Pathol"},{"key":"key20180107211624_b28-or-35-06-3357","doi-asserted-by":"crossref","first-page":"35699","DOI":"10.18632\/oncotarget.5372","article-title":"The tissue dependent interactions between p53 and Bcl-2 in vivo","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"key":"key20180107211624_b29-or-35-06-3357","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s00432-009-0621-5","article-title":"Adenovirally mediated p53 overexpression diversely influence the cell cycle of HEp-2 and CAL 27 cell lines upon cisplatin and methotrexate treatment","volume":"135","author":"Kraljevi\u0107 Paveli\u0107","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"key20180107211624_b30-or-35-06-3357","doi-asserted-by":"crossref","first-page":"e70198","DOI":"10.1371\/journal.pone.0070198","article-title":"An indirubin derivative, indirubin-3\u2032-monoxime suppresses oral cancer tumorigenesis through the downregulation of survivin","volume":"8","author":"Lo","year":"2013","journal-title":"PLoS One"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.4750\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T19:54:32Z","timestamp":1718481272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.4750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,15]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,4,15]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.3892\/or.2016.4750"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.4750","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,15]]}}}