{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:46:49Z","timestamp":1790711209104,"version":"4.1.0"},"reference-count":42,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.3892\/or.2016.4801","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T08:21:10Z","timestamp":1462868470000},"page":"117-124","source":"Crossref","is-referenced-by-count":10,"title":["Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway"],"prefix":"10.3892","volume":"36","author":[{"given":"KA HWI","family":"KIM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNG-IL","family":"CHAE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HANA","family":"OH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIN HYOUNG","family":"CHO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RA-HAM","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GOO","family":"YOON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SEUNG-SIK","family":"CHO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOUNG-SIK","family":"CHO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEE-HYUN","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KANGDONG","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HYUN-JEONG","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNG-HYUN","family":"SHIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"key20180107221839_b1-or-36-01-0117","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jcp.22724","article-title":"Malignant mesothelioma: Facts, myths, and hypotheses","volume":"227","author":"Carbone","year":"2012","journal-title":"J Cell Physiol"},{"key":"key20180107221839_b2-or-36-01-0117","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.currproblcancer.2004.04.001","article-title":"Malignant pleural mesothelioma","volume":"28","author":"Pass","year":"2004","journal-title":"Curr Probl Cancer"},{"key":"key20180107221839_b3-or-36-01-0117","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1365-2559.1997.5460776.x","article-title":"Pathology of malignant mesothelioma","volume":"30","author":"Attanoos","year":"1997","journal-title":"Histopathology"},{"key":"key20180107221839_b4-or-36-01-0117","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/bjc.2013.731","article-title":"An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma","volume":"110","author":"Linton","year":"2014","journal-title":"Br J Cancer"},{"key":"key20180107221839_b5-or-36-01-0117","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.biocel.2006.07.002","article-title":"Human malignant mesothelioma: Molecular mechanisms of pathogenesis and progression","volume":"38","author":"Spugnini","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"key20180107221839_b6-or-36-01-0117","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3892\/ijo.2013.2192","article-title":"Sialic acid-binding lectin (leczyme) induces apoptosis to malignant mesothelioma and exerts synergistic antitumor effects with TRAIL","volume":"44","author":"Tatsuta","year":"2014","journal-title":"Int J Oncol"},{"key":"key20180107221839_b7-or-36-01-0117","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2214\/ajr.161.3.8394641","article-title":"Malignant pleural mesothelioma caused by environmental exposure to asbestos or erionite in rural Turkey: CT findings in 84 patients","volume":"161","author":"Sahin","year":"1993","journal-title":"AJR Am J Roentgenol"},{"key":"key20180107221839_b8-or-36-01-0117","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1053\/sonc.2002.30227","article-title":"The pathogenesis of mesothelioma","volume":"29","author":"Carbone","year":"2002","journal-title":"Semin Oncol"},{"key":"key20180107221839_b9-or-36-01-0117","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ctrv.2011.01.001","article-title":"Advances in the biology of malignant pleural mesothelioma","volume":"37","author":"Zucali","year":"2011","journal-title":"Cancer Treat Rev"},{"key":"key20180107221839_b10-or-36-01-0117","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s12094-013-1146-6","article-title":"Expression of Wilms' tumor gene (WT1) is associated with survival in malignant pleural mesothelioma","volume":"16","author":"Cedr\u00e9s","year":"2014","journal-title":"Clin Transl Oncol"},{"key":"key20180107221839_b11-or-36-01-0117","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1378\/chest.47.5.568","article-title":"Pleural mesothelioma in patient with pulmonary tuberculosis: Report of a case","volume":"47","author":"Martinis","year":"1965","journal-title":"Dis Chest"},{"key":"key20180107221839_b12-or-36-01-0117","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/onc.2013.528","article-title":"LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade","volume":"34","author":"Tanaka","year":"2015","journal-title":"Oncogene"},{"key":"key20180107221839_b13-or-36-01-0117","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.ejca.2005.08.006","article-title":"Sp transcription factor family and its role in cancer","volume":"41","author":"Safe","year":"2005","journal-title":"Eur J Cancer"},{"key":"key20180107221839_b14-or-36-01-0117","first-page":"570","article-title":"The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters","volume":"61","author":"Aslam","year":"2001","journal-title":"Cancer Res"},{"key":"key20180107221839_b15-or-36-01-0117","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jcp.1111","article-title":"Sp1 and kr\u00fcppel-like factor family of transcription factors in cell growth regulation and cancer","volume":"188","author":"Black","year":"2001","journal-title":"J Cell Physiol"},{"key":"key20180107221839_b16-or-36-01-0117","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/jgh.12287","article-title":"Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model","volume":"28","author":"Tsuda","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"key":"key20180107221839_b17-or-36-01-0117","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1073\/pnas.90.6.2281","article-title":"Identification of Ras farnesyltransferase inhibitors by microbial screening","volume":"90","author":"Hara","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107221839_b18-or-36-01-0117","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1038\/cddis.2012.192","article-title":"Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death","volume":"4","author":"Singha","year":"2013","journal-title":"Cell Death Dis"},{"key":"key20180107221839_b19-or-36-01-0117","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00006676-199711000-00008","article-title":"Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin","volume":"15","author":"Kainuma","year":"1997","journal-title":"Pancreas"},{"key":"key20180107221839_b20-or-36-01-0117","first-page":"650","article-title":"Manumycin enhances the cytotoxic effect of paclitaxel on anaplastic thyroid carcinoma cells","volume":"60","author":"Yeung","year":"2000","journal-title":"Cancer Res"},{"key":"key20180107221839_b21-or-36-01-0117","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1210\/jcem.86.10.7860","article-title":"Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel","volume":"86","author":"Pan","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key20180107221839_b22-or-36-01-0117","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1054\/bjoc.1999.1018","article-title":"Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells","volume":"82","author":"Di Paolo","year":"2000","journal-title":"Br J Cancer"},{"key":"key20180107221839_b23-or-36-01-0117","first-page":"955","article-title":"Manumycin induces apoptosis in human hepatocellular carcinoma HepG2 cells","volume":"12","author":"Zhou","year":"2003","journal-title":"Int J Mol Med"},{"key":"key20180107221839_b24-or-36-01-0117","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/(SICI)1097-0215(19990730)82:3<430::AID-IJC17>3.0.CO;2-9","article-title":"Apoptosis of medulloblastoma cells in vitro follows inhibition of farnesylation using manumycin A","volume":"82","author":"Wang","year":"1999","journal-title":"Int J Cancer"},{"key":"key20180107221839_b25-or-36-01-0117","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2003-01-0178","article-title":"Involvement of nitric oxide in farnesyltransferase inhibitor-mediated apoptosis in chronic myeloid leukemia cells","volume":"102","author":"Selleri","year":"2003","journal-title":"Blood"},{"key":"key20180107221839_b26-or-36-01-0117","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.leu.2403691","article-title":"Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells","volume":"19","author":"She","year":"2005","journal-title":"Leukemia"},{"key":"key20180107221839_b27-or-36-01-0117","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2141.2002.03559.x","article-title":"Manumycin inhibits farnesyltransferase and induces apoptosis of drug-resistant interleukin 6-producing myeloma cells","volume":"118","author":"Frassanito","year":"2002","journal-title":"Br J Haematol"},{"key":"key20180107221839_b28-or-36-01-0117","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/ijc.23207","article-title":"Reactive oxygen species-dependent destruction of MEK and Akt in Manumycin stimulated death of lymphoid tumor and myeloma cell lines","volume":"122","author":"Sears","year":"2008","journal-title":"Int J Cancer"},{"key":"key20180107221839_b29-or-36-01-0117","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11010-009-0075-8","article-title":"Apoptotic signaling induced by benzamide riboside: An in vitro study","volume":"328","author":"Pathak","year":"2009","journal-title":"Mol Cell Biochem"},{"issue":"Suppl 10","key":"key20180107221839_b30-or-36-01-0117","first-page":"11","article-title":"Apoptosis mechanisms: Implications for cancer drug discovery","volume":"18","author":"Reed","year":"2004","journal-title":"Oncology (Williston Park)"},{"key":"key20180107221839_b31-or-36-01-0117","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/carcin\/21.3.485","article-title":"Apoptosis in cancer","volume":"21","author":"Lowe","year":"2000","journal-title":"Carcinogenesis"},{"key":"key20180107221839_b32-or-36-01-0117","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0092-8674(88)90144-4","article-title":"Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif","volume":"55","author":"Courey","year":"1988","journal-title":"Cell"},{"key":"key20180107221839_b33-or-36-01-0117","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3892\/ijo.2014.2461","article-title":"Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma","volume":"45","author":"Cho","year":"2014","journal-title":"Int J Oncol"},{"key":"key20180107221839_b34-or-36-01-0117","doi-asserted-by":"crossref","first-page":"10397","DOI":"10.7314\/APJCP.2014.15.23.10397","article-title":"Stigmalactam from Orophea enterocarpa induces human cancer cell apoptosis via a mitochondrial pathway","volume":"15","author":"Banjerdpongchai","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"key20180107221839_b35-or-36-01-0117","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.biopha.2014.10.006","article-title":"Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by \u03b2-tocotrienol in human lung and brain cancer cell lines","volume":"68","author":"Lim","year":"2014","journal-title":"Biomed Pharmacother"},{"key":"key20180107221839_b36-or-36-01-0117","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.canlet.2015.05.027","article-title":"IDH1, a CHOP and C\/EBP\u03b2-responsive gene under ER stress, sensitizes human melanoma cells to hypoxia-induced apoptosis","volume":"365","author":"Yang","year":"2015","journal-title":"Cancer Lett"},{"key":"key20180107221839_b37-or-36-01-0117","doi-asserted-by":"crossref","first-page":"e39586","DOI":"10.1371\/journal.pone.0039586","article-title":"CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress","volume":"7","author":"Ghosh","year":"2012","journal-title":"PLoS One"},{"key":"key20180107221839_b38-or-36-01-0117","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1073\/pnas.94.13.6939","article-title":"Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis","volume":"94","author":"Kharbanda","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107221839_b39-or-36-01-0117","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/caac.21208","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"key20180107221839_b40-or-36-01-0117","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/iub.51","article-title":"Bcl-2 family proteins: The sentinels of the mitochondrial apoptosis pathway","volume":"60","author":"Wong","year":"2008","journal-title":"IUBMB Life"},{"key":"key20180107221839_b41-or-36-01-0117","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-94-007-2869-1_13","article-title":"Mitochondria and cancer: A growing role in apoptosis, cancer cell metabolism and dedifferentiation","volume":"942","author":"Scatena","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"key20180107221839_b42-or-36-01-0117","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","article-title":"Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics","volume":"21","author":"Martinou","year":"2011","journal-title":"Dev Cell"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.4801\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T13:20:10Z","timestamp":1567862410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.4801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,10]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,5,10]]},"published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.3892\/or.2016.4801"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.4801","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,10]]}}}