{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:00:51Z","timestamp":1791986451668,"version":"4.4.0"},"reference-count":29,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.3892\/or.2016.5014","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T07:54:03Z","timestamp":1470902043000},"page":"1909-1916","source":"Crossref","is-referenced-by-count":26,"title":["Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, migration effects and accelerates cell cycle progression in multiple myeloma cells via activating the Akt pathway"],"prefix":"10.3892","volume":"36","author":[{"given":"Dong","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"key20180107221313_b1-or-36-04-1909","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/leu.2008.291","article-title":"Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma","volume":"23","author":"Kyle","year":"2009","journal-title":"Leukemia"},{"key":"key20180107221313_b2-or-36-04-1909","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0140-6736(09)60221-X","article-title":"Multiple myeloma","volume":"374","author":"Raab","year":"2009","journal-title":"Lancet"},{"key":"key20180107221313_b3-or-36-04-1909","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrc2189","article-title":"Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets","volume":"7","author":"Hideshima","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"key20180107221313_b4-or-36-04-1909","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1182\/blood.V98.9.2853","article-title":"The AKT kinase is activated in multiple myeloma tumor cells","volume":"98","author":"Hsu","year":"2001","journal-title":"Blood"},{"key":"key20180107221313_b5-or-36-04-1909","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1038\/sj.onc.1204833","article-title":"Biologic sequelae of interleukin-6 induced PI3-K\/Akt signaling in multiple myeloma","volume":"20","author":"Hideshima","year":"2001","journal-title":"Oncogene"},{"key":"key20180107221313_b6-or-36-04-1909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2867-3-1","article-title":"PI3-K\/Akt pathway contributes to IL-6-dependent growth of 7TD1 cells","volume":"3","author":"Zhang","year":"2003","journal-title":"Cancer Cell Int"},{"key":"key20180107221313_b7-or-36-04-1909","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","article-title":"The phosphatidylinositol 3-Kinase AKT pathway in human cancer","volume":"2","author":"Vivanco","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"key20180107221313_b8-or-36-04-1909","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/sj.onc.1205194","article-title":"Role of the AKT kinase in expansion of multiple myeloma clones: Effects on cytokine-dependent proliferative and survival responses","volume":"21","author":"Hsu","year":"2002","journal-title":"Oncogene"},{"key":"key20180107221313_b9-or-36-04-1909","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/CS20110267","article-title":"Emerging role of hydrogen sulfide in health and disease: Critical appraisal of biomarkers and pharmacological tools","volume":"121","author":"Whiteman","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"key20180107221313_b10-or-36-04-1909","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen sulfide: Its production, release and functions","volume":"41","author":"Kimura","year":"2011","journal-title":"Amino Acids"},{"key":"key20180107221313_b11-or-36-04-1909","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107221313_b12-or-36-04-1909","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00109-012-0873-4","article-title":"Hydrogen sulfide: A gasotransmitter of clinical relevance","volume":"90","author":"Vandiver","year":"2012","journal-title":"J Mol Med Berl"},{"key":"key20180107221313_b13-or-36-04-1909","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.3748\/wjg.v11.i26.3990","article-title":"Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis","volume":"11","author":"Rose","year":"2005","journal-title":"World J Gastroenterol"},{"key":"key20180107221313_b14-or-36-04-1909","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions","volume":"45","author":"Sen","year":"2012","journal-title":"Mol Cell"},{"key":"key20180107221313_b15-or-36-04-1909","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1582-4934.2009.00645.x","article-title":"Hydrogen sulfide and the vasculature: A novel vasculoprotective entity and regulator of nitric oxide bioavailability?","volume":"13","author":"Whiteman","year":"2009","journal-title":"J Cell Mol Med"},{"key":"key20180107221313_b16-or-36-04-1909","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107221313_b17-or-36-04-1909","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5142\/jgr.2012.36.2.135","article-title":"Inhibition of hydrogen sulfide-induced angiogenesis and inflammation in vascular endothelial cells: Potential mechanisms of gastric cancer prevention by Korean red ginseng","volume":"36","author":"Choi","year":"2012","journal-title":"J Ginseng Res"},{"key":"key20180107221313_b18-or-36-04-1909","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/ars.2014.5933","article-title":"The therapeutic potential of cystathionine \u03b2-synthetase\/hydrogen sulfide inhibition in cancer","volume":"22","author":"Hellmich","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"key20180107221313_b19-or-36-04-1909","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1476-5381.2010.01191.x","article-title":"Hydrogen sulphide and angiogenesis: Mechanisms and applications","volume":"164","author":"Szab\u00f3","year":"2011","journal-title":"Br J Pharmacol"},{"key":"key20180107221313_b20-or-36-04-1909","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/1541-7786.MCR-05-0126","article-title":"Evidence that hydrogen sulfide is a genotoxic agent","volume":"4","author":"Attene-Ramos","year":"2006","journal-title":"Mol Cancer Res"},{"key":"key20180107221313_b21-or-36-04-1909","doi-asserted-by":"crossref","first-page":"636410","DOI":"10.1155\/2015\/636410","article-title":"An anticancer role of hydrogen sulfide in human gastric cancer cells","volume":"2015","author":"Zhang","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"key20180107221313_b22-or-36-04-1909","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yexcr.2013.10.023","article-title":"Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: Role of PHLDA1 as an apoptosis suppressor","volume":"320","author":"Murata","year":"2014","journal-title":"Exp Cell Res"},{"key":"key20180107221313_b23-or-36-04-1909","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.3892\/ijo.2015.2914","article-title":"Exogenous hydrogen sulfide exerts proliferation\/anti-apoptosis\/angiogenesis\/migration effects via amplifying the activation of NF-\u03baB pathway in PLC\/PRF\/5 hepatoma cells","volume":"46","author":"Zhen","year":"2015","journal-title":"Int J Oncol"},{"key":"key20180107221313_b24-or-36-04-1909","first-page":"4873","article-title":"Hydrogen sulfide-releasing naproxen suppresses colon cancer cell growth and inhibits NF-\u03baB signaling","volume":"9","author":"Kodela","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"key20180107221313_b25-or-36-04-1909","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","article-title":"Hydrogen sulfide chemical biology: Pathophysiological roles and detection","volume":"35","author":"Kolluru","year":"2013","journal-title":"Nitric Oxide"},{"key":"key20180107221313_b26-or-36-04-1909","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol Rev"},{"key":"key20180107221313_b27-or-36-04-1909","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ijc.10628","article-title":"Inhibition of apoptosis in human breast cancer cells: Role in tumor progression to the metastatic state","volume":"101","author":"Fern\u00e1ndez","year":"2002","journal-title":"Int J Cancer"},{"key":"key20180107221313_b28-or-36-04-1909","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1158\/1078-0432.CCR-06-2921","article-title":"Targeting the phosphatidylinositol 3-kinase pathway in multiple myeloma","volume":"13","author":"Younes","year":"2007","journal-title":"Clin Cancer Res"},{"key":"key20180107221313_b29-or-36-04-1909","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CBI20090368","article-title":"Hydrogen sulfide induces human colon cancer cell proliferation: Role of Akt, ERK and p21","volume":"34","author":"Cai","year":"2010","journal-title":"Cell Biol Int"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2016.5014\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T22:15:11Z","timestamp":1515363311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2016.5014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,11]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,8,11]]},"published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.3892\/or.2016.5014"],"URL":"https:\/\/doi.org\/10.3892\/or.2016.5014","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,11]]}}}