{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:23:54Z","timestamp":1792157034556,"version":"4.4.0"},"reference-count":47,"publisher":"Spandidos Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.3892\/or.2017.5450","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T12:42:41Z","timestamp":1487076161000},"page":"2277-2285","source":"Crossref","is-referenced-by-count":120,"title":["Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells"],"prefix":"10.3892","volume":"37","author":[{"given":"Guangming","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"key20180107224457_b1-or-37-04-2277","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12967-015-0753-0","article-title":"Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells","volume":"14","author":"Liu","year":"2016","journal-title":"J Transl Med"},{"key":"key20180107224457_b2-or-37-04-2277","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1586\/era.09.25","article-title":"Current systemic therapy for metastatic melanoma","volume":"9","author":"Agarwala","year":"2009","journal-title":"Expert Rev Anticancer Ther"},{"key":"key20180107224457_b3-or-37-04-2277","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC Melanoma Staging and Classification","volume":"27","author":"Balch","year":"2009","journal-title":"J Clin Oncol"},{"key":"key20180107224457_b4-or-37-04-2277","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.critrevonc.2015.12.002","article-title":"The rapidly evolving therapies for advanced melanoma - Towards immunotherapy, molecular targeted therapy, and beyond","volume":"99","author":"Zhu","year":"2015","journal-title":"Crit Rev Oncol Hematol"},{"key":"key20180107224457_b5-or-37-04-2277","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijpharm.2012.07.002","article-title":"Biopharmaceutics classification and intestinal absorption study of apigenin","volume":"436","author":"Zhang","year":"2012","journal-title":"Int J Pharm"},{"key":"key20180107224457_b6-or-37-04-2277","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.2147\/IJN.S60938","article-title":"Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion","volume":"9","author":"Ding","year":"2014","journal-title":"Int J Nanomedicine"},{"key":"key20180107224457_b7-or-37-04-2277","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ptr.3245","article-title":"Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy","volume":"25","author":"Arsi\u0107","year":"2011","journal-title":"Phytother Res"},{"key":"key20180107224457_b8-or-37-04-2277","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijpharm.2011.08.018","article-title":"Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation","volume":"420","author":"Al Shaal","year":"2011","journal-title":"Int J Pharm"},{"key":"key20180107224457_b9-or-37-04-2277","first-page":"233","article-title":"Apigenin and cancer chemoprevention: Progress, potential and promise (Review)","volume":"30","author":"Patel","year":"2007","journal-title":"Int J Oncol"},{"key":"key20180107224457_b10-or-37-04-2277","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12935-015-0186-0","article-title":"Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis","volume":"15","author":"Shi","year":"2015","journal-title":"Cancer Cell Int"},{"key":"key20180107224457_b11-or-37-04-2277","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3892\/ijo.2014.2808","article-title":"Inhibition of IL-6\/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells","volume":"46","author":"Suh","year":"2015","journal-title":"Int J Oncol"},{"key":"key20180107224457_b12-or-37-04-2277","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/carcin\/bgt316","article-title":"Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K\/Akt\/FoxO pathway","volume":"35","author":"Shukla","year":"2014","journal-title":"Carcinogenesis"},{"key":"key20180107224457_b13-or-37-04-2277","doi-asserted-by":"crossref","first-page":"31216","DOI":"10.18632\/oncotarget.5157","article-title":"Apigenin blocks IKK\u03b1 activation and suppresses prostate cancer progression","volume":"6","author":"Shukla","year":"2015","journal-title":"Oncotarget"},{"key":"key20180107224457_b14-or-37-04-2277","doi-asserted-by":"crossref","first-page":"133","DOI":"10.32607\/20758251-2015-7-3-133-139","article-title":"Apigenin inhibits growth of breast cancer cells: The role of ER\u03b1 and HER2\/neu","volume":"7","author":"Scherbakov","year":"2015","journal-title":"Acta naturae"},{"key":"key20180107224457_b15-or-37-04-2277","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.3892\/mmr.2015.3698","article-title":"Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells","volume":"12","author":"Seo","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20180107224457_b16-or-37-04-2277","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/1097-0215(20000815)87:4<595::AID-IJC21>3.0.CO;2-5","article-title":"Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential","volume":"87","author":"Caltagirone","year":"2000","journal-title":"Int J Cancer"},{"key":"key20180107224457_b17-or-37-04-2277","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.phymed.2010.06.004","article-title":"Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells","volume":"18","author":"Ye","year":"2010","journal-title":"Phytomedicine"},{"key":"key20180107224457_b18-or-37-04-2277","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3322\/canjclin.55.3.178","article-title":"Targeting apoptosis pathways in cancer therapy","volume":"55","author":"Ghobrial","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"key20180107224457_b19-or-37-04-2277","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2013.07.057","article-title":"Depletion of intracellular zinc induces apoptosis of cultured hippocampal neurons through suppression of ERK signaling pathway and activation of caspase-3","volume":"552","author":"Pang","year":"2013","journal-title":"Neurosci Lett"},{"key":"key20180107224457_b20-or-37-04-2277","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1146\/annurev.biochem.68.1.965","article-title":"AKT\/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation","volume":"68","author":"Chan","year":"1999","journal-title":"Annu Rev Biochem"},{"key":"key20180107224457_b21-or-37-04-2277","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2003.09.002","article-title":"Photodynamic therapy of skin cancer: Controlled drug delivery of 5-ALA and its esters","volume":"56","author":"Lopez","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"key20180107224457_b22-or-37-04-2277","first-page":"S84","article-title":"Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2","volume":"52","author":"Eggler","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"key20180107224457_b23-or-37-04-2277","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11095-010-0089-7","article-title":"Apigenin: A promising molecule for cancer prevention","volume":"27","author":"Shukla","year":"2010","journal-title":"Pharm Res"},{"key":"key20180107224457_b24-or-37-04-2277","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2014.02.012","article-title":"Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion","volume":"101","author":"Kim","year":"2014","journal-title":"Life Sci"},{"key":"key20180107224457_b25-or-37-04-2277","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-4598-8-8","article-title":"Centrosome-associated regulators of the G2\/M checkpoint as targets for cancer therapy","volume":"8","author":"Wang","year":"2009","journal-title":"Mol Cancer"},{"key":"key20180107224457_b26-or-37-04-2277","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1128\/MCB.25.8.3364-3387.2005","article-title":"Phosphorylation of p21 in G2\/M promotes cyclin B-Cdc2 kinase activity","volume":"25","author":"Dash","year":"2005","journal-title":"Mol Cell Biol"},{"key":"key20180107224457_b27-or-37-04-2277","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0165-6147(03)00026-9","article-title":"Cell-cycle dysregulation and anticancer therapy","volume":"24","author":"Stewart","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"key20180107224457_b28-or-37-04-2277","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3892\/ijo.2014.2339","article-title":"Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells","volume":"44","author":"Lee","year":"2014","journal-title":"Int J Oncol"},{"key":"key20180107224457_b29-or-37-04-2277","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1039\/C5FO00671F","article-title":"Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells","volume":"6","author":"Zhang","year":"2015","journal-title":"Food Funct"},{"key":"key20180107224457_b30-or-37-04-2277","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1475-2867-13-54","article-title":"Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells","volume":"13","author":"Zhu","year":"2013","journal-title":"Cancer Cell Int"},{"key":"key20180107224457_b31-or-37-04-2277","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jcp.20395","article-title":"Akt-induced promotion of cell-cycle progression at G2\/M phase involves upregulation of NF-Y binding activity in PC12 cells","volume":"205","author":"Lee","year":"2005","journal-title":"J Cell Physiol"},{"key":"key20180107224457_b32-or-37-04-2277","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nrd1902","article-title":"Exploiting the PI3K\/AKT pathway for cancer drug discovery","volume":"4","author":"Hennessy","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"key20180107224457_b33-or-37-04-2277","doi-asserted-by":"crossref","first-page":"e31286","DOI":"10.1371\/journal.pone.0031286","article-title":"Caffeic acid phenethyl ester causes p21Cip1 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"key":"key20180107224457_b34-or-37-04-2277","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2016.08.019","article-title":"The flavonoid apigenin reduces prostate cancer CD44+ stem cell survival and migration through PI3K-Akt\/NF-\u03baB signaling","volume":"162","author":"Erdogan","year":"2016","journal-title":"Life Sci"},{"key":"key20180107224457_b35-or-37-04-2277","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1136\/bmj.322.7301.1536","article-title":"What is apoptosis, and why is it important?","volume":"322","author":"Renehan","year":"2001","journal-title":"BMJ"},{"key":"key20180107224457_b36-or-37-04-2277","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4291\/wjgp.v3.i3.71","article-title":"Molecular signaling mechanisms of apoptosis in hereditary non-polyposis colorectal cancer","volume":"3","author":"Hassen","year":"2012","journal-title":"World J Gastrointest Pathophysiol"},{"key":"key20180107224457_b37-or-37-04-2277","doi-asserted-by":"crossref","first-page":"22932","DOI":"10.1074\/jbc.274.33.22932","article-title":"Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells","volume":"274","author":"Boulares","year":"1999","journal-title":"J Biol Chem"},{"key":"key20180107224457_b38-or-37-04-2277","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11010-012-1310-2","article-title":"Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NF\u03baB signaling in HER2-overexpressing breast cancer cells","volume":"366","author":"Seo","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"key20180107224457_b39-or-37-04-2277","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10495-014-0971-6","article-title":"Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer","volume":"19","author":"Shukla","year":"2014","journal-title":"Apoptosis"},{"key":"key20180107224457_b40-or-37-04-2277","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1258\/ebm.2012.012148","article-title":"Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria","volume":"237","author":"Das","year":"2012","journal-title":"Exp Biol Med (Maywood)"},{"key":"key20180107224457_b41-or-37-04-2277","doi-asserted-by":"crossref","first-page":"15219","DOI":"10.1073\/pnas.1107304108","article-title":"Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice","volume":"108","author":"Choi","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107224457_b42-or-37-04-2277","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1158\/1078-0432.CCR-10-1276","article-title":"Riluzole enhances ionizing radiation-induced cytotoxicity in human melanoma cells that ectopically express metabotropic glutamate receptor 1 in vitro and in vivo","volume":"17","author":"Khan","year":"2011","journal-title":"Clin Cancer Res"},{"key":"key20180107224457_b43-or-37-04-2277","doi-asserted-by":"crossref","first-page":"7080","DOI":"10.1158\/1078-0432.CCR-11-0098","article-title":"Glutamatergic pathway targeting in melanoma: Single-agent and combinatorial therapies","volume":"17","author":"Lee","year":"2011","journal-title":"Clin Cancer Res"},{"key":"key20180107224457_b44-or-37-04-2277","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bcp.2015.08.091","article-title":"Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells","volume":"98","author":"Gelb","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"key20180107224457_b45-or-37-04-2277","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.bbagrm.2012.06.005","article-title":"Regulation of mGluR1 expression in human melanocytes and melanoma cells","volume":"1819","author":"Lee","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"key20180107224457_b46-or-37-04-2277","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/exd.12048","article-title":"Blocking glutamate-mediated signalling inhibits human melanoma growth and migration.","volume":"21","author":"Song","year":"2012","journal-title":"Exp Dermatol"},{"key":"key20180107224457_b47-or-37-04-2277","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbrc.2008.11.109","article-title":"Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells","volume":"378","author":"Tanimura","year":"2009","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/spandidos-publications.com\/10.3892\/or.2017.5450\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T10:57:04Z","timestamp":1601636224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2017.5450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,14]]},"published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.3892\/or.2017.5450"],"URL":"https:\/\/doi.org\/10.3892\/or.2017.5450","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,14]]}}}