{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:52:34Z","timestamp":1768564354514,"version":"3.49.0"},"reference-count":44,"publisher":"Spandidos Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.3892\/or.2017.5627","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T11:03:00Z","timestamp":1493895780000},"page":"3423-3432","source":"Crossref","is-referenced-by-count":27,"title":["Plumbagin enhances TRAIL-induced apoptosis of human leukemic Kasumi-1 cells through upregulation of TRAIL death receptor expression, activation of caspase-8 and inhibition of cFLIP"],"prefix":"10.3892","volume":"37","author":[{"given":"Xiaoyang","family":"Kong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongpeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunjiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengkai","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"key20180107225134_b1-or-37-06-3423","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/sj.cdd.4401187","article-title":"Apo2L\/TRAIL and its death and decoy receptors","volume":"10","author":"LeBlanc","year":"2003","journal-title":"Cell Death Differ"},{"key":"key20180107225134_b2-or-37-06-3423","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ctrv.2008.11.006","article-title":"TRAIL receptor signalling and modulation: Are we on the right TRAIL?","volume":"35","author":"Mahalingam","year":"2009","journal-title":"Cancer Treat Rev"},{"key":"key20180107225134_b3-or-37-06-3423","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.pharmthera.2013.06.009","article-title":"Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling","volume":"140","author":"Sessler","year":"2013","journal-title":"Pharmacol Ther"},{"key":"key20180107225134_b4-or-37-06-3423","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1200\/JCO.2007.15.7198","article-title":"Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2\/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L\/TRAIL)","volume":"26","author":"Ashkenazi","year":"2008","journal-title":"J Clin Oncol"},{"key":"key20180107225134_b5-or-37-06-3423","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1172\/JCI6926","article-title":"Safety and antitumor activity of recombinant soluble Apo2 ligand","volume":"104","author":"Ashkenazi","year":"1999","journal-title":"J Clin Invest"},{"key":"key20180107225134_b6-or-37-06-3423","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/sj.cgt.7700792","article-title":"Mechanisms of resistance to TRAIL-induced apoptosis in cancer","volume":"12","author":"Zhang","year":"2005","journal-title":"Cancer Gene Ther"},{"key":"key20180107225134_b7-or-37-06-3423","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.drup.2004.11.002","article-title":"Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: Paving the road to patient-tailored therapy","volume":"7","author":"Van Geelen","year":"2004","journal-title":"Drug Resist Updat"},{"key":"key20180107225134_b8-or-37-06-3423","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0022-5347(05)00160-6","article-title":"Targeting death receptors in bladder, prostate and renal cancer","volume":"175","author":"O'Kane","year":"2006","journal-title":"J Urol"},{"key":"key20180107225134_b9-or-37-06-3423","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1158\/1535-7163.MCT-06-0050","article-title":"Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand\/TRAIL","volume":"5","author":"Cheng","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"key20180107225134_b10-or-37-06-3423","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/med.20235","article-title":"Perspectives on medicinal properties of plumbagin and its analogs","volume":"32","author":"Padhye","year":"2012","journal-title":"Med Res Rev"},{"key":"key20180107225134_b11-or-37-06-3423","first-page":"876","article-title":"Plumbagin: A study of its anticancer, antibacterial & antifungal properties","volume":"18","author":"Krishnaswamy","year":"1980","journal-title":"Indian J Exp Biol"},{"key":"key20180107225134_b12-or-37-06-3423","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.phytochem.2009.10.013","article-title":"Antifungal constituents isolated from the seeds of Aegle marmelos","volume":"71","author":"Mishra","year":"2010","journal-title":"Phytochemistry"},{"key":"key20180107225134_b13-or-37-06-3423","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0162-3109(95)00027-Q","article-title":"Modulatory effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) on macrophage functions in BALB\/c mice. I. Potentiation of macrophage bactericidal activity","volume":"30","author":"Abdul","year":"1995","journal-title":"Immunopharmacology"},{"key":"key20180107225134_b14-or-37-06-3423","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1007\/s00436-014-4015-5","article-title":"Antimalarial efficacy of dynamic compound of plumbagin chemical constituent from Plumbago zeylanica Linn (Plumbaginaceae) against the malarial vector Anopheles stephensi Liston (Diptera: Culicidae)","volume":"113","author":"Pradeepa","year":"2014","journal-title":"Parasitol Res"},{"key":"key20180107225134_b15-or-37-06-3423","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s10753-013-9768-y","article-title":"Plumbagin, a vitamin K3 analogue, abrogates lipopolysaccharide-induced oxidative stress, inflammation and endotoxic shock via NF-\u03baB suppression","volume":"37","author":"Checker","year":"2014","journal-title":"Inflammation"},{"key":"key20180107225134_b16-or-37-06-3423","first-page":"10","article-title":"Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits","volume":"35","author":"Sharma","year":"1991","journal-title":"Indian J Physiol Pharmacol"},{"key":"key20180107225134_b17-or-37-06-3423","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1016\/j.fct.2012.08.046","article-title":"Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats","volume":"50","author":"Sunil","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"key20180107225134_b18-or-37-06-3423","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1471-4159.2009.06552.x","article-title":"Plumbagin, a novel Nrf2\/ARE activator, protects against cerebral ischemia","volume":"112","author":"Son","year":"2010","journal-title":"J Neurochem"},{"key":"key20180107225134_b19-or-37-06-3423","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.leukres.2009.08.017","article-title":"Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo","volume":"34","author":"Xu","year":"2010","journal-title":"Leuk Res"},{"key":"key20180107225134_b20-or-37-06-3423","doi-asserted-by":"crossref","first-page":"10011","DOI":"10.3390\/molecules190710011","article-title":"Plumbagin modulates leukemia cell redox status","volume":"19","author":"Gaascht","year":"2014","journal-title":"Molecules"},{"key":"key20180107225134_b21-or-37-06-3423","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1124\/jpet.105.098863","article-title":"Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo","volume":"318","author":"Hsu","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"key20180107225134_b22-or-37-06-3423","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11010-009-0254-7","article-title":"Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung cancer cells","volume":"335","author":"Shieh","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"key20180107225134_b23-or-37-06-3423","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1158\/0008-5472.CAN-08-2494","article-title":"Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer","volume":"68","author":"Aziz","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107225134_b24-or-37-06-3423","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1021\/np3000409","article-title":"Plumbagin induces apoptosis in Her2-overexpressing breast cancer cells through the mitochondrial-mediated pathway","volume":"75","author":"Kawiak","year":"2012","journal-title":"J Nat Prod"},{"key":"key20180107225134_b25-or-37-06-3423","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1158\/1535-7163.MCT-06-0478","article-title":"Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT\/mammalian target of rapamycin pathway in breast cancer cells","volume":"5","author":"Kuo","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"key20180107225134_b26-or-37-06-3423","doi-asserted-by":"crossref","first-page":"e45023","DOI":"10.1371\/journal.pone.0045023","article-title":"The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS One"},{"key":"key20180107225134_b27-or-37-06-3423","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/ijc.27724","article-title":"Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo","volume":"132","author":"Sinha","year":"2013","journal-title":"Int J Cancer"},{"key":"key20180107225134_b28-or-37-06-3423","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/mc.20359","article-title":"Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway","volume":"47","author":"Nair","year":"2008","journal-title":"Mol Carcinog"},{"key":"key20180107225134_b29-or-37-06-3423","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2007.10.005","article-title":"Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species\/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells","volume":"259","author":"Wang","year":"2008","journal-title":"Cancer Lett"},{"key":"key20180107225134_b30-or-37-06-3423","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1200\/JCO.2005.15.610","article-title":"Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): A Cancer and Leukemia Group B study","volume":"23","author":"Marcucci","year":"2005","journal-title":"J Clin Oncol"},{"key":"key20180107225134_b31-or-37-06-3423","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1182\/blood.V77.9.2031.2031","article-title":"Establishment of a human acute myeloid leukemia cell line (Kasumi-1) with 8;21 chromosome translocation","volume":"77","author":"Asou","year":"1991","journal-title":"Blood"},{"key":"key20180107225134_b32-or-37-06-3423","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1126\/science.276.5309.111","article-title":"The receptor for the cytotoxic ligand TRAIL","volume":"276","author":"Pan","year":"1997","journal-title":"Science"},{"key":"key20180107225134_b33-or-37-06-3423","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1093\/emboj\/16.17.5386","article-title":"TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL","volume":"16","author":"Walczak","year":"1997","journal-title":"EMBO J"},{"key":"key20180107225134_b34-or-37-06-3423","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrc821","article-title":"Targeting death and decoy receptors of the tumour-necrosis factor superfamily","volume":"2","author":"Ashkenazi","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"key20180107225134_b35-or-37-06-3423","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10495-008-0306-6","article-title":"Cell death in hematological tumors","volume":"14","author":"Fulda","year":"2009","journal-title":"Apoptosis"},{"key":"key20180107225134_b36-or-37-06-3423","doi-asserted-by":"crossref","first-page":"e3999","DOI":"10.1371\/journal.pone.0003999","article-title":"Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae","volume":"3","author":"Castro","year":"2008","journal-title":"PLoS One"},{"key":"key20180107225134_b37-or-37-06-3423","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.leukres.2011.06.018","article-title":"Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression","volume":"35","author":"Sun","year":"2011","journal-title":"Leuk Res"},{"key":"key20180107225134_b38-or-37-06-3423","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1089\/ars.2012.4553","article-title":"Glutathione efflux and cell death","volume":"17","author":"Franco","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"key20180107225134_b39-or-37-06-3423","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/tx034132s","article-title":"Cytotoxic action of juglone and plumbagin: A mechanistic study using HaCaT keratinocytes","volume":"17","author":"Inbaraj","year":"2004","journal-title":"Chem Res Toxicol"},{"key":"key20180107225134_b40-or-37-06-3423","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11596-010-0449-x","article-title":"Plumbagin enhances TRAIL-mediated apoptosis through up-regulation of death receptor in human melanoma A375 cells","volume":"30","author":"Li","year":"2010","journal-title":"J Huazhong Univ Sci Technol"},{"key":"key20180107225134_b41-or-37-06-3423","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ccell.2015.02.014","article-title":"Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis","volume":"27","author":"von Karstedt","year":"2015","journal-title":"Cancer Cell"},{"key":"key20180107225134_b42-or-37-06-3423","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1158\/0008-5472.CAN-04-3903","article-title":"Proapoptotic activity of new glutathione S-transferase inhibitors","volume":"65","author":"Turella","year":"2005","journal-title":"Cancer Res"},{"key":"key20180107225134_b43-or-37-06-3423","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2010.05.013","article-title":"Plumbagin-induced apoptosis in lymphocytes is mediated through increased reactive oxygen species production, upregulation of Fas, and activation of the caspase cascade","volume":"247","author":"McKallip","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"key20180107225134_b44-or-37-06-3423","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1182\/blood.V97.5.1378","article-title":"Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95\/Fas receptor-ligand interaction and occurs downstream of caspase-3","volume":"97","author":"Wieder","year":"2001","journal-title":"Blood"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T22:46:37Z","timestamp":1602024397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2017.5627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,4]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,5,4]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.3892\/or.2017.5627"],"URL":"https:\/\/doi.org\/10.3892\/or.2017.5627","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,4]]}}}