{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:31:58Z","timestamp":1759775518712},"reference-count":43,"publisher":"Spandidos Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.3892\/or.2017.5646","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T08:04:23Z","timestamp":1495008263000},"page":"449-455","source":"Crossref","is-referenced-by-count":15,"title":["Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities"],"prefix":"10.3892","volume":"38","author":[{"given":"Junko","family":"Masuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Strober","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Honjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Ichi","family":"Tokuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Nakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan J.","family":"Fuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Shigehiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Kawaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Mizuno-Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Kondoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Seno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"key20180107220824_b1-or-38-01-0449","doi-asserted-by":"crossref","first-page":"e1061175","DOI":"10.1080\/2162402X.2015.1061175","article-title":"CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis","volume":"5","author":"Liu","year":"2015","journal-title":"OncoImmunology"},{"key":"key20180107220824_b2-or-38-01-0449","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.4049\/jimmunol.0802740","article-title":"Myeloid-derived suppressor cells: Linking inflammation and cancer","volume":"182","author":"Ostrand-Rosenberg","year":"2009","journal-title":"J Immunol"},{"key":"key20180107220824_b3-or-38-01-0449","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0065-230X(10)07003-X","article-title":"Regulatory T cells in cancer","volume":"107","author":"Mougiakakos","year":"2010","journal-title":"Adv Cancer Res"},{"key":"key20180107220824_b4-or-38-01-0449","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1158\/0008-5472.CAN-07-5301","article-title":"Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2","volume":"68","author":"Fichtner-Feigl","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107220824_b5-or-38-01-0449","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.4049\/jimmunol.0902661","article-title":"Mechanism of T cell tolerance induced by myeloid-derived suppressor cells","volume":"184","author":"Nagaraj","year":"2010","journal-title":"J Immunol"},{"key":"key20180107220824_b6-or-38-01-0449","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/hed.21464","article-title":"Serum IL10 and circulating CD4(+) CD25(high) regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma","volume":"33","author":"Alhamarneh","year":"2011","journal-title":"Head Neck"},{"key":"key20180107220824_b7-or-38-01-0449","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.immunol.18.1.423","article-title":"Regulatory T cells in autoimmmunity","volume":"18","author":"Shevach","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"key20180107220824_b8-or-38-01-0449","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2249.2011.04445.x","article-title":"Immuno-suppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus","volume":"166","author":"Chen","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"key20180107220824_b9-or-38-01-0449","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.4049\/jimmunol.1201449","article-title":"Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer","volume":"190","author":"Yu","year":"2013","journal-title":"J Immunol"},{"key":"key20180107220824_b10-or-38-01-0449","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.4049\/jimmunol.1301365","article-title":"Gr-1dimCD11b+ immature myeloid-derived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice","volume":"192","author":"Tsiganov","year":"2014","journal-title":"J Immunol"},{"key":"key20180107220824_b11-or-38-01-0449","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.181.8.5791","article-title":"Subsets of myeloid-derived suppressor cells in tumor-bearing mice","volume":"181","author":"Youn","year":"2008","journal-title":"J Immunol"},{"key":"key20180107220824_b12-or-38-01-0449","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ccell.2014.11.009","article-title":"Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation","volume":"27","author":"Rutkowski","year":"2015","journal-title":"Cancer Cell"},{"key":"key20180107220824_b13-or-38-01-0449","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.leukres.2016.02.004","article-title":"Myeloid-derived suppressor cells in patients with myeloproliferative neoplasm","volume":"43","author":"Wang","year":"2016","journal-title":"Leuk Res"},{"key":"key20180107220824_b14-or-38-01-0449","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1158\/0008-5472.CAN-15-1490","article-title":"Myeloid-derived suppressor cells express Bruton's tyrosine kinase and can be depleted in tumor-bearing hosts by ibrutinib treatment","volume":"76","author":"Stiff","year":"2016","journal-title":"Cancer Res"},{"key":"key20180107220824_b15-or-38-01-0449","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.1182\/blood-2010-06-287839","article-title":"Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13","volume":"116","author":"Highfill","year":"2010","journal-title":"Blood"},{"key":"key20180107220824_b16-or-38-01-0449","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature07210","article-title":"T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance","volume":"455","author":"Pesu","year":"2008","journal-title":"Nature"},{"key":"key20180107220824_b17-or-38-01-0449","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.immuni.2010.09.001","article-title":"Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I","volume":"33","author":"Xu","year":"2010","journal-title":"Immunity"},{"key":"key20180107220824_b18-or-38-01-0449","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/hed.20739","article-title":"Regulatory T cells: What role do they play in antitumor immunity in patients with head and neck cancer?","volume":"30","author":"Alhamarneh","year":"2008","journal-title":"Head Neck"},{"key":"key20180107220824_b19-or-38-01-0449","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ni.1607","article-title":"A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells","volume":"9","author":"Liu","year":"2008","journal-title":"Nat Immunol"},{"key":"key20180107220824_b20-or-38-01-0449","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00262-011-1028-0","article-title":"Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13","volume":"60","author":"Gabitass","year":"2011","journal-title":"Cancer Immunol Immunother"},{"key":"key20180107220824_b21-or-38-01-0449","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1242\/jcs.036467","article-title":"EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility","volume":"122","author":"Yamazaki","year":"2009","journal-title":"J Cell Sci"},{"key":"key20180107220824_b22-or-38-01-0449","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.4049\/jimmunol.164.11.5652","article-title":"Mouse CD8+ CD122+ T cells with intermediate TCR increasing with age provide a source of early IFN-gamma production","volume":"164","author":"Takayama","year":"2000","journal-title":"J Immunol"},{"key":"key20180107220824_b23-or-38-01-0449","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key20180107220824_b24-or-38-01-0449","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.20022227","article-title":"Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: Abrogation prevents tumor recurrence","volume":"198","author":"Terabe","year":"2003","journal-title":"J Exp Med"},{"key":"key20180107220824_b25-or-38-01-0449","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.celrep.2015.08.077","article-title":"Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner","volume":"13","author":"Holmgaard","year":"2015","journal-title":"Cell Rep"},{"key":"key20180107220824_b26-or-38-01-0449","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4049\/jimmunol.1403225","article-title":"Tr1 cells, but not Foxp3+ regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10-dependent mechanism","volume":"195","author":"Yao","year":"2015","journal-title":"J Immunol"},{"key":"key20180107220824_b27-or-38-01-0449","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/mi.2011.7","article-title":"The role of IL-10 in immune regulation during M. tuberculosis infection","volume":"4","author":"Redford","year":"2011","journal-title":"Mucosal Immunol"},{"key":"key20180107220824_b28-or-38-01-0449","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key20180107220824_b29-or-38-01-0449","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4049\/jimmunol.1000356","article-title":"TGF-beta induces IL-9 production from human Th17 cells","volume":"185","author":"Beriou","year":"2010","journal-title":"J Immunol"},{"key":"key20180107220824_b30-or-38-01-0449","doi-asserted-by":"crossref","first-page":"e1004983","DOI":"10.1080\/2162402X.2015.1004983","article-title":"Phenotype, development, and biological function of myeloid-derived suppressor cells","volume":"5","author":"Zhao","year":"2015","journal-title":"OncoImmunology"},{"key":"key20180107220824_b31-or-38-01-0449","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40169-015-0048-3","article-title":"EMT and tumor metastasis","volume":"4","author":"Heerboth","year":"2015","journal-title":"Clin Transl Med"},{"key":"key20180107220824_b32-or-38-01-0449","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3892\/ol.2014.2391","article-title":"Clinical significance of serum T helper 1\/T helper 2 cytokine shift in patients with non-small cell lung cancer","volume":"8","author":"Li","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180107220824_b33-or-38-01-0449","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10549-013-2549-3","article-title":"Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers","volume":"139","author":"Hong","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"key20180107220824_b34-or-38-01-0449","first-page":"1803","article-title":"Relationship between cytokine levels and clinical classification of gastric cancer","volume":"12","author":"Liang","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"key20180107220824_b35-or-38-01-0449","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1080\/21645515.2015.1009814","article-title":"Clinically feasible approaches to potentiating cancer cell-based immunotherapies","volume":"11","author":"Seledtsov","year":"2015","journal-title":"Hum Vaccin Immunother"},{"key":"key20180107220824_b36-or-38-01-0449","first-page":"3951","article-title":"Impaired production of Th1 cytokines and increased frequency of Th2 subsets in PBMC from advanced cancer patients","volume":"18D","author":"Sato","year":"1998","journal-title":"Anticancer Res"},{"key":"key20180107220824_b37-or-38-01-0449","first-page":"5005","article-title":"Preoperative plasma level of IL-10 but not of proinflammatory cytokines is an independent prognostic factor in patients with gastric cancer","volume":"29","author":"Szaflarska","year":"2009","journal-title":"Anticancer Res"},{"key":"key20180107220824_b38-or-38-01-0449","first-page":"82","article-title":"Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients","volume":"48","author":"Koz\u0142owski","year":"2003","journal-title":"Rocz Akad Med Bialymst"},{"key":"key20180107220824_b39-or-38-01-0449","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1124\/pr.55.2.4","article-title":"Interleukin-10 therapy - review of a new approach","volume":"55","author":"Asadullah","year":"2003","journal-title":"Pharmacol Rev"},{"key":"key20180107220824_b40-or-38-01-0449","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.4049\/jimmunol.166.9.5439","article-title":"The mechanism of a defective IFN-\u03b3 response to bacterial toxins in an atopic dermatitis model, NC\/Nga mice, and the therapeutic effect of IFN-\u03b3, IL-12, or IL-18 on dermatitis","volume":"166","author":"Habu","year":"2001","journal-title":"J Immunol"},{"key":"key20180107220824_b41-or-38-01-0449","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nri2848","article-title":"Cellular sources and immune functions of interleukin-9","volume":"10","author":"Noelle","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"key20180107220824_b42-or-38-01-0449","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1172\/JCI65459","article-title":"Th9 cells promote antitumor immune responses in vivo","volume":"122","author":"Lu","year":"2012","journal-title":"J Clin Invest"},{"key":"key20180107220824_b43-or-38-01-0449","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3892\/etm.2015.2588","article-title":"Association between low expression levels of interleukin-9 and colon cancer progression","volume":"10","author":"Huang","year":"2015","journal-title":"Exp Ther Med"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T05:13:25Z","timestamp":1719206005000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2017.5646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,5,17]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.3892\/or.2017.5646"],"URL":"https:\/\/doi.org\/10.3892\/or.2017.5646","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}