{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:15:33Z","timestamp":1773724533868,"version":"3.50.1"},"reference-count":32,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.3892\/or.2017.5758","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T10:08:14Z","timestamp":1498558094000},"page":"1133-1139","source":"Crossref","is-referenced-by-count":21,"title":["MicroRNA-31 inhibits tumor invasion and metastasis by targeting RhoA in human gastric cancer"],"prefix":"10.3892","volume":"38","author":[{"given":"Fulin","family":"Ge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changzheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"key20180107220641_b1-or-38-02-1133","first-page":"302","article-title":"Risk factors in gastric cancer","volume":"14","author":"Compare","year":"2010","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"key20180107220641_b2-or-38-02-1133","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrc1098","article-title":"The pathogenesis of cancer metastasis: The \u2018seed and soil\u2019 hypothesis revisited","volume":"3","author":"Fidler","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"key20180107220641_b3-or-38-02-1133","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer metastasis: Building a framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"key20180107220641_b4-or-38-02-1133","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tig.2008.06.004","article-title":"Micromanagers of malignancy: Role of microRNAs in regulating metastasis","volume":"24","author":"Ma","year":"2008","journal-title":"Trends Genet"},{"key":"key20180107220641_b5-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1111444","article-title":"Ribo-gnome: The big world of small RNAs","volume":"309","author":"Zamore","year":"2005","journal-title":"Science"},{"key":"key20180107220641_b6-or-38-02-1133","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2006.09.009","article-title":"The diverse functions of microRNAs in animal development and disease","volume":"11","author":"Kloosterman","year":"2006","journal-title":"Dev Cell"},{"key":"key20180107220641_b7-or-38-02-1133","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Esquela-Kerscher","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"key20180107220641_b8-or-38-02-1133","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"key20180107220641_b9-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.cell.2009.03.047","article-title":"A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis","volume":"137","author":"Valastyan","year":"2009","journal-title":"Cell"},{"key":"key20180107220641_b10-or-38-02-1133","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1186\/1471-2407-10-616","article-title":"Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells","volume":"10","author":"Wang","year":"2010","journal-title":"BMC Cancer"},{"key":"key20180107220641_b11-or-38-02-1133","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3727\/096504012X13522227232156","article-title":"The identification of miR-375 as a potential biomarker in distal gastric adenocarcinoma","volume":"20","author":"Zhang","year":"2012","journal-title":"Oncol Res"},{"key":"key20180107220641_b12-or-38-02-1133","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key20180107220641_b13-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/ijc.24827","article-title":"Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma","volume":"126","author":"Schaefer","year":"2010","journal-title":"Int J Cancer"},{"key":"key20180107220641_b14-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1158\/0008-5472.CAN-09-3875","article-title":"Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers","volume":"70","author":"Creighton","year":"2010","journal-title":"Cancer Res"},{"key":"key20180107220641_b15-or-38-02-1133","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1155\/2009\/921907","article-title":"Clinicopathological significance of microRNA-31, \u2212143 and \u2212145 expression in colorectal cancer","volume":"26","author":"Wang","year":"2009","journal-title":"Dis Markers"},{"key":"key20180107220641_b16-or-38-02-1133","first-page":"1069","article-title":"Over- and under-expressed microRNAs in human colorectal cancer","volume":"34","author":"Motoyama","year":"2009","journal-title":"Int J Oncol"},{"key":"key20180107220641_b17-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1158\/0008-5472.CAN-09-2291","article-title":"miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma","volume":"70","author":"Liu","year":"2010","journal-title":"Cancer Res"},{"key":"key20180107220641_b18-or-38-02-1133","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/j.gastro.2008.04.003","article-title":"MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1","volume":"135","author":"Wong","year":"2008","journal-title":"Gastroenterology"},{"key":"key20180107220641_b19-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI39566","article-title":"MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors","volume":"120","author":"Liu","year":"2010","journal-title":"J Clin Invest"},{"key":"key20180107220641_b20-or-38-02-1133","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1245\/s10434-009-0624-0","article-title":"Prognostic significance of microscopic positive margins for gastric cancer patients with potentially curative resection","volume":"16","author":"Sun","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"key20180107220641_b21-or-38-02-1133","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/jso.21678","article-title":"Clinicopathologic characteristics and prognosis of gastric cancer invading the subserosa","volume":"102","author":"Jiang","year":"2010","journal-title":"J Surg Oncol"},{"key":"key20180107220641_b22-or-38-02-1133","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1158\/1541-7786.MCR-12-0534","article-title":"miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells","volume":"11","author":"Zheng","year":"2013","journal-title":"Mol Cancer Res"},{"key":"key20180107220641_b23-or-38-02-1133","doi-asserted-by":"crossref","first-page":"e18409","DOI":"10.1371\/journal.pone.0018409","article-title":"MicroRNA let-7f inhibits tumor invasion and metastasis by targeting MYH9 in human gastric cancer","volume":"6","author":"Liang","year":"2011","journal-title":"PLoS One"},{"key":"key20180107220641_b24-or-38-02-1133","doi-asserted-by":"crossref","first-page":"e1000879","DOI":"10.1371\/journal.pgen.1000879","article-title":"MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor","volume":"6","author":"Tie","year":"2010","journal-title":"PLoS Genet"},{"key":"key20180107220641_b25-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.111.3.1001","article-title":"Microinjection of recombinant p21rho induces rapid changes in cell morphology","volume":"111","author":"Paterson","year":"1990","journal-title":"J Cell Biol"},{"key":"key20180107220641_b26-or-38-02-1133","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1128\/MCB.13.1.72","article-title":"Involvement of rho p21 and its inhibitory GDP\/GTP exchange protein (rho GDI) in cell motility","volume":"13","author":"Takaishi","year":"1993","journal-title":"Mol Cell Biol"},{"key":"key20180107220641_b27-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1083\/jcb.120.5.1187","article-title":"Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP\/GTP exchange protein (rho GDI)","volume":"120","author":"Kishi","year":"1993","journal-title":"J Cell Biol"},{"key":"key20180107220641_b28-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1083\/jcb.149.7.1391","article-title":"CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis","volume":"149","author":"Jantsch-Plunger","year":"2000","journal-title":"J Cell Biol"},{"key":"key20180107220641_b29-or-38-02-1133","doi-asserted-by":"crossref","first-page":"8719","DOI":"10.1016\/S0021-9258(19)50337-4","article-title":"Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction","volume":"267","author":"Hirata","year":"1992","journal-title":"J Biol Chem"},{"key":"key20180107220641_b30-or-38-02-1133","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1073\/pnas.93.3.1340","article-title":"Role of guanine nucleotide-binding proteins - ras-family or trimeric proteins or both - in Ca2+ sensitization of smooth muscle","volume":"93","author":"Gong","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20180107220641_b31-or-38-02-1133","first-page":"1285","article-title":"Tumorigenic activity of rho genes from Aplysia californica","volume":"8","author":"Perona","year":"1993","journal-title":"Oncogene"},{"key":"key20180107220641_b32-or-38-02-1133","first-page":"2289","article-title":"Critical role of Rho in cell transformation by oncogenic Ras","volume":"10","author":"Prendergast","year":"1995","journal-title":"Oncogene"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:44:48Z","timestamp":1719276288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2017.5758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,6,27]]},"published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.3892\/or.2017.5758"],"URL":"https:\/\/doi.org\/10.3892\/or.2017.5758","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}