{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:20:50Z","timestamp":1790738450775,"version":"4.1.0"},"reference-count":50,"publisher":"Spandidos Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.3892\/or.2017.5977","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T11:20:03Z","timestamp":1505906403000},"page":"2825-2835","source":"Crossref","is-referenced-by-count":43,"title":["Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest"],"prefix":"10.3892","volume":"38","author":[{"given":"Kyoko","family":"Oura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Tadokoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Fujihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahiro","family":"Morishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Chiyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Samukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Yamana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kobara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisakazu","family":"Iwama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2249","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"key":"key20180107220508_b1-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","article-title":"Hepatocellular carcinoma","volume":"379","author":"Forner","year":"2012","journal-title":"Lancet"},{"key":"key20180107220508_b2-or-38-05-2825","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/ajg.2014.11","article-title":"Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States","volume":"109","author":"Altekruse","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"key20180107220508_b3-or-38-05-2825","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000173419","article-title":"Organizing Committee of Japan-Korea Liver Symposium: Epidemiology of hepatocellular carcinoma in Japan and Korea. A review","volume":"75","author":"Kim","year":"2008","journal-title":"Oncology"},{"key":"key20180107220508_b4-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hepr.12310","article-title":"Review of angiogenesis in hepatocellular carcinoma","volume":"45","author":"Muto","year":"2015","journal-title":"Hepatol Res"},{"key":"key20180107220508_b5-or-38-05-2825","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1872-034X.2007.00304.x","article-title":"Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines","volume":"38","author":"Itabashi","year":"2008","journal-title":"Hepatol Res"},{"key":"key20180107220508_b6-or-38-05-2825","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000363429","article-title":"Genetic association study of angiotensin II receptor types 1 (A168G) and 2 (T1247G and A5235G) polymorphisms in breast carcinoma among Brazilian Women","volume":"9","author":"Wolgien","year":"2014","journal-title":"Breast Care (Basel)"},{"issue":"15s","key":"key20180107220508_b7-or-38-05-2825","first-page":"1","article-title":"Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis","volume":"62","author":"Miyajima","year":"2002","journal-title":"Cancer Res"},{"key":"key20180107220508_b8-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3892\/ijo_00000287","article-title":"Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1\/2, NF-kappaB and survivin","volume":"34","author":"Kinoshita","year":"2009","journal-title":"Int J Oncol"},{"key":"key20180107220508_b9-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3892\/ijo_00000776","article-title":"Angiotensin II induces tumor progression and fibrosis in intrahepatic cholangiocarcinoma through an interaction with hepatic stellate cells","volume":"37","author":"Okamoto","year":"2010","journal-title":"Int J Oncol"},{"key":"key20180107220508_b10-or-38-05-2825","first-page":"1893","article-title":"Angiotensin II receptor type 1 blockers suppress the cell proliferation effects of angiotensin II in breast cancer cells by inhibiting AT1R signaling","volume":"27","author":"Du","year":"2012","journal-title":"Oncol Rep"},{"key":"key20180107220508_b11-or-38-05-2825","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.canlet.2012.10.006","article-title":"Angiotensin II type 1 receptor antagonists inhibit cell proliferation and angiogenesis in breast cancer","volume":"328","author":"Chen","year":"2013","journal-title":"Cancer Lett"},{"key":"key20180107220508_b12-or-38-05-2825","doi-asserted-by":"crossref","first-page":"e93050","DOI":"10.1371\/journal.pone.0093050","article-title":"Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells","volume":"9","author":"Koyama","year":"2014","journal-title":"PLoS One"},{"key":"key20180107220508_b13-or-38-05-2825","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.canlet.2014.09.019","article-title":"The angiotensin II type 1 receptor blocker candesartan suppresses proliferation and fibrosis in gastric cancer","volume":"355","author":"Okazaki","year":"2014","journal-title":"Cancer Lett"},{"key":"key20180107220508_b14-or-38-05-2825","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S1470-2045(10)70106-6","article-title":"Angiotensin-receptor blockade and risk of cancer: Meta-analysis of randomised controlled trials","volume":"11","author":"Sipahi","year":"2010","journal-title":"Lancet Oncol"},{"key":"key20180107220508_b15-or-38-05-2825","doi-asserted-by":"crossref","first-page":"e2697","DOI":"10.1136\/bmj.e2697","article-title":"Angiotensin receptor blockers and risk of cancer: Cohort study among people receiving antihypertensive drugs in UK General Practice Research Database","volume":"344","author":"Bhaskaran","year":"2012","journal-title":"BMJ"},{"key":"key20180107220508_b16-or-38-05-2825","doi-asserted-by":"crossref","first-page":"djt374","DOI":"10.1093\/jnci\/djt374","article-title":"Angiotensin-converting enzyme inhibitor therapy and colorectal cancer risk","volume":"106","author":"Makar","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"key20180107220508_b17-or-38-05-2825","first-page":"295","article-title":"Telmisartan is a potent target for prevention and treatment in human prostate cancer","volume":"20","author":"Funao","year":"2008","journal-title":"Oncol Rep"},{"key":"key20180107220508_b18-or-38-05-2825","first-page":"193","article-title":"Telmisartan as a peroxisome proliferator-activated receptor-\u03b3 ligand is a new target in the treatment of human renal cell carcinoma","volume":"2","author":"Funao","year":"2009","journal-title":"Mol Med Rep"},{"key":"key20180107220508_b19-or-38-05-2825","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.3892\/ol.2014.2592","article-title":"Antiproliferative and apoptotic effects of telmisartan in human colon cancer cells","volume":"8","author":"Lee","year":"2014","journal-title":"Oncol Lett"},{"key":"key20180107220508_b20-or-38-05-2825","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/2211-5463.12055","article-title":"Angiotensin II type 1 receptor blocker telmisartan induces apoptosis and autophagy in adult T-cell leukemia cells","volume":"6","author":"Kozako","year":"2016","journal-title":"FEBS Open Bio"},{"key":"key20180107220508_b21-or-38-05-2825","doi-asserted-by":"crossref","first-page":"8536","DOI":"10.18632\/oncotarget.14345","article-title":"The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPK\u03b1\/mTOR pathway in vitro and in vivo","volume":"8","author":"Fujihara","year":"2017","journal-title":"Oncotarget"},{"key":"key20180107220508_b22-or-38-05-2825","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ardp.201300402","article-title":"Role of AMP-activated protein kinase in cancer therapy","volume":"347","author":"Rehman","year":"2014","journal-title":"Arch Pharm (Weinheim)"},{"key":"key20180107220508_b23-or-38-05-2825","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.febslet.2006.04.068","article-title":"The amino acid sensitive TOR pathway from yeast to mammals","volume":"580","author":"Dann","year":"2006","journal-title":"FEBS Lett"},{"key":"key20180107220508_b24-or-38-05-2825","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","article-title":"Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression","volume":"23","author":"Fingar","year":"2004","journal-title":"Oncogene"},{"key":"key20180107220508_b25-or-38-05-2825","first-page":"661","article-title":"Comparison study of the expressions of myristoylated alanine-rich C kinase substrate in hepatocellular carcinoma, liver cirrhosis, chronic hepatitis, and normal liver","volume":"26","author":"Masaki","year":"2005","journal-title":"Int J Oncol"},{"key":"key20180107220508_b26-or-38-05-2825","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"key20180107220508_b27-or-38-05-2825","doi-asserted-by":"crossref","unstructured":"TowbinHStaehelinTGordonJElectrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applicationsProc Natl Acad Sci USA7643504354197910.1073\/pnas.76.9.4350388439411572","DOI":"10.1073\/pnas.76.9.4350"},{"key":"key20180107220508_b28-or-38-05-2825","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yexcr.2004.02.019","article-title":"Keratin 8\/18 breakdown and reorganization during apoptosis","volume":"297","author":"Schutte","year":"2004","journal-title":"Exp Cell Res"},{"key":"key20180107220508_b29-or-38-05-2825","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"key20180107220508_b30-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3892\/ol.2016.4853","article-title":"MicroRNA profiles in various hepatocellular carcinoma cell lines","volume":"12","author":"Morishita","year":"2016","journal-title":"Oncol Lett"},{"key":"key20180107220508_b31-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/ajh\/hpw095","article-title":"The use of telmisartan and the incidence of cancer","volume":"29","author":"Tascilar","year":"2016","journal-title":"Am J Hypertens"},{"key":"key20180107220508_b32-or-38-05-2825","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1053\/jhep.2003.50112","article-title":"Cyclins and cyclin-dependent kinases: Comparative study of hepatocellular carcinoma versus cirrhosis","volume":"37","author":"Masaki","year":"2003","journal-title":"Hepatology"},{"key":"key20180107220508_b33-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.3748\/wjg.14.1734","article-title":"Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma","volume":"14","author":"Matsuda","year":"2008","journal-title":"World J Gastroenterol"},{"key":"key20180107220508_b34-or-38-05-2825","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.atherosclerosis.2015.01.037","article-title":"Telmisartan enhances mitochondrial activity and alters cellular functions in human coronary artery endothelial cells via AMP-activated protein kinase pathway","volume":"239","author":"Kurokawa","year":"2015","journal-title":"Atherosclerosis"},{"key":"key20180107220508_b35-or-38-05-2825","doi-asserted-by":"crossref","first-page":"e96948","DOI":"10.1371\/journal.pone.0096948","article-title":"Telmisartan activates endothelial nitric oxide synthase via Ser1177 phosphorylation in vascular endothelial cells","volume":"9","author":"Myojo","year":"2014","journal-title":"PLoS One"},{"key":"key20180107220508_b36-or-38-05-2825","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab"},{"key":"key20180107220508_b37-or-38-05-2825","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"key20180107220508_b38-or-38-05-2825","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1158\/1535-7163.MCT-11-0594","article-title":"The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo","volume":"11","author":"Kato","year":"2012","journal-title":"Mol Cancer Ther"},{"key":"key20180107220508_b39-or-38-05-2825","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1038\/sj.onc.1211024","article-title":"The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level","volume":"27","author":"Ben Sahra","year":"2008","journal-title":"Oncogene"},{"key":"key20180107220508_b40-or-38-05-2825","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3892\/etm_00000046","article-title":"Telmisartan inhibits human urological cancer cell growth through early apoptosis","volume":"1","author":"Matsuyama","year":"2010","journal-title":"Exp Ther Med"},{"key":"key20180107220508_b41-or-38-05-2825","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1038\/sj.onc.1210279","article-title":"TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer","volume":"26","author":"Hussain","year":"2007","journal-title":"Oncogene"},{"key":"key20180107220508_b42-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1007\/s10620-014-3058-x","article-title":"Molecular therapies in hepatocellular carcinoma: What can we target?","volume":"59","author":"Galuppo","year":"2014","journal-title":"Dig Dis Sci"},{"key":"key20180107220508_b43-or-38-05-2825","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/hepr.12386","article-title":"miRNA in hepatocellular carcinoma","volume":"45","author":"Morishita","year":"2015","journal-title":"Hepatol Res"},{"key":"key20180107220508_b44-or-38-05-2825","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.23380","article-title":"Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma","volume":"51","author":"Xiong","year":"2010","journal-title":"Hepatology"},{"key":"key20180107220508_b45-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/carcin\/bgr078","article-title":"miR-29c induces cell cycle arrest in esophageal squamous cell carcinoma by modulating cyclin E expression","volume":"32","author":"Ding","year":"2011","journal-title":"Carcinogenesis"},{"key":"key20180107220508_b46-or-38-05-2825","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1091\/mbc.E13-05-0287","article-title":"miR-29b represses intestinal mucosal growth by inhibiting translation of cyclin-dependent kinase 2","volume":"24","author":"Xiao","year":"2013","journal-title":"Mol Biol Cell"},{"key":"key20180107220508_b47-or-38-05-2825","doi-asserted-by":"crossref","first-page":"e56824","DOI":"10.1371\/journal.pone.0056824","article-title":"miR-126&126* restored expressions play a tumor suppressor role by directly regulating ADAM9 and MMP7 in melanoma","volume":"8","author":"Felli","year":"2013","journal-title":"PLoS One"},{"key":"key20180107220508_b48-or-38-05-2825","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/hep.23381","article-title":"MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes","volume":"51","author":"Braconi","year":"2010","journal-title":"Hepatology"},{"key":"key20180107220508_b49-or-38-05-2825","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1158\/0008-5472.CAN-08-2103","article-title":"MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions","volume":"68","author":"Reddy","year":"2008","journal-title":"Cancer Res"},{"key":"key20180107220508_b50-or-38-05-2825","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/onc.2013.108","article-title":"miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1","volume":"33","author":"Wu","year":"2014","journal-title":"Oncogene"}],"container-title":["Oncology Reports"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T20:46:19Z","timestamp":1750884379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.spandidos-publications.com\/10.3892\/or.2017.5977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,20]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,9,20]]},"published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.3892\/or.2017.5977"],"URL":"https:\/\/doi.org\/10.3892\/or.2017.5977","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,20]]}}}