{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:01Z","timestamp":1774656001002,"version":"3.50.1"},"reference-count":46,"publisher":"Spandidos Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Rep"],"DOI":"10.3892\/or.2022.8467","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T10:16:17Z","timestamp":1671617777000},"source":"Crossref","is-referenced-by-count":4,"title":["Macrophage renewal modes affect acquired resistance to gefitinib in EGFR\u2011mutant lung cancer PC\u20119 cells"],"prefix":"10.3892","volume":"49","author":[{"given":"Baoxia","family":"Zhao","sequence":"first","affiliation":[{"name":"Scientific Research Center, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Scientific Research Center, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Lu","sequence":"additional","affiliation":[{"name":"Scientific Research Center, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Scientific Research Center, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2249","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"key20230125130237_b1-or-49-02-08467","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"key20230125130237_b2-or-49-02-08467","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1200\/JCO.2012.43.3912","article-title":"Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease","volume":"31","author":"Ohashi","year":"2013","journal-title":"J Clin Oncol"},{"key":"key20230125130237_b3-or-49-02-08467","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3390\/cancers13040804","article-title":"Targeted therapy in advanced and metastatic non-small cell lung cancer. An update on treatment of the most important actionable oncogenic driver alterations","volume":"13","author":"Konig","year":"2021","journal-title":"Cancers (Basel)"},{"key":"key20230125130237_b4-or-49-02-08467","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nm.4091","article-title":"A framework for understanding and targeting residual disease in oncogene-driven solid cancers","volume":"22","author":"Bivona","year":"2016","journal-title":"Nat Med"},{"key":"key20230125130237_b5-or-49-02-08467","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12943-019-1062-7","article-title":"Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations","volume":"18","author":"Lin","year":"2019","journal-title":"Mol Cancer"},{"key":"key20230125130237_b6-or-49-02-08467","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1084\/jem.20180534","article-title":"Macrophages of distinct origins contribute to tumor development in the lung","volume":"215","author":"Loyher","year":"2018","journal-title":"J Exp Med"},{"key":"key20230125130237_b7-or-49-02-08467","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2407-12-35","article-title":"Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors","volume":"12","author":"Bonde","year":"2012","journal-title":"BMC Cancer"},{"key":"key20230125130237_b8-or-49-02-08467","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"key20230125130237_b9-or-49-02-08467","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ccr.2013.02.013","article-title":"Macrophage regulation of tumor responses to anticancer therapies","volume":"23","author":"De Palma","year":"2013","journal-title":"Cancer Cell"},{"key":"key20230125130237_b10-or-49-02-08467","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1084\/jem.20150295","article-title":"The interaction of anticancer therapies with tumor-associated macrophages","volume":"212","author":"Mantovani","year":"2015","journal-title":"J Exp Med"},{"key":"key20230125130237_b11-or-49-02-08467","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1002\/ijc.32191","article-title":"EGFR-targeted therapy alters the tumor microenvironment in EGFR-driven lung tumors: Implications for combination therapies","volume":"145","author":"Jia","year":"2019","journal-title":"Int J Cancer"},{"key":"key20230125130237_b12-or-49-02-08467","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1158\/1078-0432.CCR-15-2597","article-title":"Progression of EGFR-mutant lung adenocarcinoma is driven by alveolar macrophages","volume":"23","author":"Wang","year":"2017","journal-title":"Clin Cancer Res"},{"key":"key20230125130237_b13-or-49-02-08467","doi-asserted-by":"publisher","first-page":"e000778","DOI":"10.1136\/jitc-2020-000778","article-title":"M1(hot) tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer","volume":"8","author":"Garrido-Martin","year":"2020","journal-title":"J Immunother Cancer"},{"key":"key20230125130237_b14-or-49-02-08467","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1111\/1759-7714.13670","article-title":"M2 macrophages reduce the effect of gefitinib by activating AKT\/mTOR in gefitinib-resistant cell lines HCC827\/GR","volume":"11","author":"Xiao","year":"2020","journal-title":"Thorac Cancer"},{"key":"key20230125130237_b15-or-49-02-08467","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12032-014-0127-0","article-title":"M2-polarized macrophages contribute to the decreased sensitivity of EGFR-TKIs treatment in patients with advanced lung adenocarcinoma","volume":"31","author":"Zhang","year":"2014","journal-title":"Med Oncol"},{"key":"key20230125130237_b16-or-49-02-08467","doi-asserted-by":"publisher","first-page":"E227","DOI":"10.1002\/ijc.27403","article-title":"Tumor-associated macrophages correlate with response to epidermal growth factor receptor-tyrosine kinase inhibitors in advanced non-small cell lung cancer","volume":"131","author":"Chung","year":"2012","journal-title":"Int J Cancer"},{"key":"key20230125130237_b17-or-49-02-08467","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/imr.12224","article-title":"Tissue macrophage identity and self-renewal","volume":"262","author":"Gentek","year":"2014","journal-title":"Immunol Rev"},{"key":"key20230125130237_b18-or-49-02-08467","doi-asserted-by":"publisher","first-page":"199ra110","DOI":"10.1126\/scitranslmed.3005773","article-title":"Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy","volume":"5","author":"Mascia","year":"2013","journal-title":"Sci Transl Med"},{"key":"key20230125130237_b19-or-49-02-08467","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"key20230125130237_b20-or-49-02-08467","doi-asserted-by":"publisher","first-page":"eaba7350","DOI":"10.1126\/sciimmunol.aba7350","article-title":"Functional heterogeneity of alveolar macrophage population based on expression of CXCL2","volume":"5","author":"Xu-Vanpala","year":"2020","journal-title":"Sci Immunol"},{"key":"key20230125130237_b21-or-49-02-08467","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2020.11.011","article-title":"Crosstalk between alveolar macrophages and alveolar epithelial cells\/fibroblasts contributes to the pulmonary toxicity of gefitinib","volume":"338","author":"Du","year":"2021","journal-title":"Toxicol Lett"},{"key":"key20230125130237_b22-or-49-02-08467","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/ijms20010116","article-title":"Lung macrophages: Multifunctional regulator cells for metastatic cells","volume":"20","author":"Mukaida","year":"2018","journal-title":"Int J Mol Sci"},{"key":"key20230125130237_b23-or-49-02-08467","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.lungcan.2018.07.015","article-title":"The intratumoral distribution influences the prognostic impact of CD68- and CD204-positive macrophages in non-small cell lung cancer","volume":"123","author":"Li","year":"2018","journal-title":"Lung Cancer"},{"key":"key20230125130237_b24-or-49-02-08467","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41586-021-03651-8","article-title":"Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells","volume":"595","author":"Casanova-Acebes","year":"2021","journal-title":"Nature"},{"key":"key20230125130237_b25-or-49-02-08467","doi-asserted-by":"publisher","first-page":"960","DOI":"10.3390\/cells10040960","article-title":"Tissue-resident and recruited macrophages in primary tumor and metastatic microenvironments: Potential targets in cancer therapy","volume":"10","author":"Cotechini","year":"2021","journal-title":"Cells"},{"key":"key20230125130237_b26-or-49-02-08467","doi-asserted-by":"publisher","first-page":"A3.B.1","DOI":"10.1002\/0471142735.ima03bs111","article-title":"Trypan blue exclusion test of cell viability","volume":"111","author":"Strober","year":"2015","journal-title":"Curr Protoc Immunol"},{"key":"key20230125130237_b27-or-49-02-08467","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.3892\/mmr.2014.3058","article-title":"Establishment and biological characteristics of acquired gefitinib resistance in cell line NCI-H1975\/gefinitib-resistant with epidermal growth factor receptor T790M mutation","volume":"11","author":"Zhao","year":"2015","journal-title":"Mol Med Rep"},{"key":"key20230125130237_b28-or-49-02-08467","doi-asserted-by":"publisher","first-page":"74","DOI":"10.4149\/neo_2011_01_74","article-title":"The different clinical significance of EGFR mutations in exon 19 and 21 in non-small cell lung cancer patients of China","volume":"58","author":"Li","year":"2011","journal-title":"Neoplasma"},{"key":"key20230125130237_b29-or-49-02-08467","first-page":"391","article-title":"Difference between LCGreen PLUS and EvaGreen in detecting EGFR mutation with HRM","volume":"42","author":"Sun Xuerui","year":"2020","journal-title":"J Dalian Med Univ"},{"key":"key20230125130237_b30-or-49-02-08467","article-title":"A language and environment for statistical computing","author":"R Core Team. R"},{"key":"key20230125130237_b31-or-49-02-08467","doi-asserted-by":"publisher","first-page":"T69","DOI":"10.1530\/JME-17-0311","article-title":"IGF1 receptor signaling pathways","volume":"61","author":"Hakuno","year":"2018","journal-title":"J Mol Endocrinol"},{"key":"key20230125130237_b32-or-49-02-08467","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.cellsig.2018.09.002","article-title":"TGF-\u03b2 receptors: In and beyond TGF-beta signaling","volume":"52","author":"Ark","year":"2018","journal-title":"Cell Signal"},{"key":"key20230125130237_b33-or-49-02-08467","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrc.2017.84","article-title":"Understanding and targeting resistance mechanisms in NSCLC","volume":"17","author":"Rotow","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"key20230125130237_b34-or-49-02-08467","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1126\/science.1099314","article-title":"EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy","volume":"304","author":"Paez","year":"2004","journal-title":"Science"},{"key":"key20230125130237_b35-or-49-02-08467","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-\u03b2 signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"key20230125130237_b36-or-49-02-08467","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.3390\/ijms19051294","article-title":"TGF-\u03b2 and the tissue microenvironment: Relevance in fibrosis and cancer","volume":"19","author":"Caja","year":"2018","journal-title":"Int J Mol Sci"},{"key":"key20230125130237_b37-or-49-02-08467","doi-asserted-by":"publisher","first-page":"903e904","DOI":"10.1016\/j.immuni.2017.10.007","article-title":"The cytokine TGF-beta promotes the development and homeostasis of alveolar macrophages","volume":"47","author":"Yu","year":"2017","journal-title":"Immunity"},{"key":"key20230125130237_b38-or-49-02-08467","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.canlet.2013.11.013","article-title":"CD68(+)HLA-DR(+) M1-like macrophages promote motility of HCC cells via NF-\u03baB\/FAK pathway","volume":"345","author":"Wang","year":"2014","journal-title":"Cancer Lett"},{"key":"key20230125130237_b39-or-49-02-08467","doi-asserted-by":"publisher","first-page":"15535","DOI":"10.1073\/pnas.1009472107","article-title":"TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer","volume":"107","author":"Yao","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key20230125130237_b40-or-49-02-08467","doi-asserted-by":"publisher","first-page":"e0201796","DOI":"10.1371\/journal.pone.0201796","article-title":"NF-\u03baB activation is an early event of changes in gene regulation for acquiring drug resistance in human adenocarcinoma PC-9 cells","volume":"13","author":"Fukuoka","year":"2018","journal-title":"PLoS One"},{"key":"key20230125130237_b41-or-49-02-08467","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/s10753-020-01281-2","article-title":"Gefitinib-induced cutaneous toxicities in brown norway rats are associated with macrophage infiltration","volume":"43","author":"Wan","year":"2020","journal-title":"Inflammation"},{"key":"key20230125130237_b42-or-49-02-08467","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.3390\/ijms21093233","article-title":"Mechanisms of multidrug resistance in cancer chemotherapy","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int J Mol Sci"},{"key":"key20230125130237_b43-or-49-02-08467","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/0008-5472.CAN-20-2990","article-title":"Macrophage-based approaches for cancer immunotherapy","volume":"81","author":"Anderson","year":"2021","journal-title":"Cancer Res"},{"key":"key20230125130237_b44-or-49-02-08467","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3322\/caac.21596","article-title":"A review of cancer immunotherapy toxicity","volume":"70","author":"Kennedy","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"key20230125130237_b45-or-49-02-08467","doi-asserted-by":"publisher","first-page":"e0160004","DOI":"10.1371\/journal.pone.0160004","article-title":"Immune-modulation by epidermal growth factor receptor inhibitors: Implication on anti-tumor immunity in lung cancer","volume":"11","author":"Im","year":"2016","journal-title":"PLoS One"},{"key":"key20230125130237_b46-or-49-02-08467","doi-asserted-by":"publisher","first-page":"102134","DOI":"10.1016\/j.ctrv.2020.102134","article-title":"Association between immune-related side effects and efficacy and benefit of immune checkpoint inhibitors-A systematic review and meta-analysis","volume":"92","author":"Hussaini","year":"2021","journal-title":"Cancer Treat Rev"}],"container-title":["Oncology Reports"],"original-title":[],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T11:03:10Z","timestamp":1674644590000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.spandidos-publications.com\/10.3892\/or.2022.8467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,12,21]]}},"URL":"https:\/\/doi.org\/10.3892\/or.2022.8467","relation":{},"ISSN":["1021-335X","1791-2431"],"issn-type":[{"value":"1021-335X","type":"print"},{"value":"1791-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"article-number":"30"}}