{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:37:15Z","timestamp":1792643835429,"version":"4.5.0"},"reference-count":0,"publisher":"Pensoft Publishers","issue":"2","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Management of beta-thalassemia major (TM) requires life-long hemotransfusions leading to iron overload. Iron elimination is enhanced by the use of modern chelators.&amp;nbsp;<\/jats:p>\n          <jats:p><jats:bold>Aim:<\/jats:bold> To assess the effect of modern chelation therapy by dynamics of serum ferritin concentration and liver MRI T2*.<\/jats:p>\n          <jats:p><jats:bold>Patients and methods:<\/jats:bold> Forty-six patients with TM (male to female ratio =1:1, mean age 33.2&amp;plusmn;10.9 years) were prospectively studied between 2011 and 2014. Twenty-one patients (45.7%) were treated with deferasirox, 17 (37%) &amp;ndash; with deferiprone, and 8 (17.3%) &amp;ndash; with deferiprone in combination with deferoxamine. Ferritin was measured by ELISA. MRI T2* was assessed by Siemens Magnetom Avanto 1.5T. The patients were allocated into 3 groups based on their initial ferritin level and liver MRI T2*. Statistical analysis was performed using SPSS v. 18 for Windows. Data were analysed by descriptive analysis, analysis of variance and correlative analysis, means were compared using t-test and one-way ANOVA.<\/jats:p>\n          <jats:p><jats:bold>Results:<\/jats:bold> In 2011, 9 (19.5%) patients had normal liver MRI T2*; in 2014 they were 17 (37%). The patients with mild grade liver siderosis were 12 (26%) in 2011, and in 2014 they were 14 (30.4%). In 2011, the patients with moderate liver siderosis were 14 (30.4%), and in 2014 &amp;ndash; 12 (26.0%). Eleven patients (23.9%) had severe liver siderosis in 2011 and only two patients (4.0%) were diagnosed with the condition in 2014.<\/jats:p>\n          <jats:p><jats:bold>Conclusion:<\/jats:bold> A reduction of iron overload was found in all studied groups. This positive effect is attributed to the use of modern chelators and the ease of access to accurate monitoring.<\/jats:p>","DOI":"10.3897\/folmed.62.e39518","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T18:18:46Z","timestamp":1593541126000},"page":"265-270","source":"Crossref","is-referenced-by-count":2,"title":["Reduction of Liver Iron Load in Adult Patients with &amp;beta;-Thalassemia Major Treated with Modern Chelation Modalities"],"prefix":"10.3897","volume":"62","author":[{"given":"Pencho G.","family":"Georgiev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya G.","family":"Sapunarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-162X","authenticated-orcid":true,"given":"Veselina S.","family":"Goranova-Marinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan E.","family":"Goranov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2020,6,30]]},"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/39518\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/39518\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=39518&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T18:18:46Z","timestamp":1593541126000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/39518\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6,30]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.62.e39518","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,30]]}}}