{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:46:52Z","timestamp":1747223212075,"version":"3.40.5"},"reference-count":0,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Inroduction:<\/jats:bold> Oxidative stress is an important pathogenetic factor in a number of socially significant diseases, including the acute exogenous poisoning. Homocysteine is a sulfur-containing amino acid synthesized on the basis of methionine, which plays an important role as an oxidizing agent in the human body. As such a factor, it was the monitored subject of this study.<\/jats:p>\n          <jats:p><jats:bold>Aim:<\/jats:bold> To measure the level of homocysteine in acute exogenous poisoning with alcohol, heroin and cerebro-toxic drugs.<\/jats:p>\n          <jats:p><jats:bold>Materials and methods:<\/jats:bold> This is a prospective longitudinal study including 118 patients with moderate or severe acute poisoning with cerebro-toxic drugs (n=45), alcohol (n=40), heroin (n=33) and a &amp;ldquo;control group&amp;rdquo; (n=35). Clinical laboratory tests were performed according to the standards of a clinical laboratory. In the statistical analysis we used alternative and variance analysis, parametric methods for hypothesis assessment, and nonparametric methods for normal distribution.<\/jats:p>\n          <jats:p><jats:bold>Results and discussion:<\/jats:bold> The results showed that for the three groups of intoxications, the average homocysteine levels were higher than those of the control group (&amp;#1088;&lt;0.001). The intergroup comparison criterion for normal distribution showed that the changes in patients with alcohol intoxication (u=3.39; &amp;#1088;&lt;0.001) and heroin intoxication (u=2.00; &amp;#1088;&lt;0.001) were highly statistically significant without correlating with the severity of the poisoning (&amp;#1088;&gt;0.05).<\/jats:p>\n          <jats:p><jats:bold>Conclusion:<\/jats:bold> There is a risk of oxidative stress in intoxication with alcohol and narcotics. A reliable marker for the complex evaluation of oxidative stress in people is monitoring the serum level of homocysteine and its careful interpretation.<\/jats:p>","DOI":"10.3897\/folmed.62.e49220","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T14:54:03Z","timestamp":1601477643000},"page":"519-524","source":"Crossref","is-referenced-by-count":0,"title":["Acute exogenous intoxications and homocysteine"],"prefix":"10.3897","volume":"62","author":[{"given":"Stoilka","family":"Tufkova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Paskaleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-0829","authenticated-orcid":true,"given":"Milena","family":"Sandeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2020,9,30]]},"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/49220\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/49220\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=49220&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T14:54:04Z","timestamp":1601477644000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/49220\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,9,30]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.62.e49220","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"type":"electronic","value":"1314-2143"},{"type":"print","value":"0204-8043"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}