{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:23:24Z","timestamp":1785446604024,"version":"3.56.0"},"reference-count":0,"publisher":"Pensoft Publishers","issue":"4","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>Vitamin D is a secosteroid hormone with known beneficial effects on several body systems other than the musculoskeletal system.&amp;nbsp;Both 25 dihydroxy vitamin D [25(OH)2D] and its active hormonal form, 1,25-dihydroxyvitamin D [1,25(OH)2D] are essential for hu-man physiological functions, including damping down inflammation and the excessive intracellular oxidative stresses. In the present study we set out to review all available literature on vitamin D and the role it plays in epigenetics and gene regulation. We searched the PubMed\/Medline electronic database for studies published in the English language up to January 2020. The Medical Subject Headings (MeSH) database was searched with the keywords &amp;lsquo;vitamin D&amp;rsquo;, &amp;lsquo;DNA methylation&amp;rsquo;, &amp;lsquo;nutritional supplements&amp;rsquo;, &amp;lsquo;epigenome&amp;rsquo; and &amp;lsquo;pregnancy&amp;rsquo;. Observational studies, supplementation studies, and meta-analyses dealing with the effect of vitamin D on epigenetics and gene regula-tion were included in the review. The obtained information from the databases such as PubMed, Google Scholar, and ResearchGate was analysed and summarized.&amp;nbsp;We found that hypovitaminosis D increases the incidence and severity of several age-related common diseases such as the oxidative stress-associated metabolic disorders. These include obesity, insulin resistance, type 2 diabetes, hypertension, pregnancy complications, memory disorders, osteoporosis, autoimmune diseases, certain cancers, and systemic inflammatory diseases. New understandings of vitamin D-related advances in metabolomics, transcriptomics, epigenetics, in relation to its ability to control oxidative stress in conjunc-tion with micronutrients, vitamins, and antioxidants, following normalization of serum 25(OH)D and tissue 1,25(OH)2D concentra-tions, are likely to promise better cost-effective clinical outcomes in humans.&amp;nbsp;There is a strong reciprocity between the vitamin D system and epigenetic mechanisms. The vitamin D system is, on the one hand regu-lated by epigenetic mechanisms and, on the other hand, is involved in regulating epigenetic events.<\/jats:p>","DOI":"10.3897\/folmed.62.e50204.","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T11:22:35Z","timestamp":1609413755000},"page":"662-667","source":"Crossref","is-referenced-by-count":28,"title":["Vitamin D: a Review of its Effects on&amp;nbsp;Epigenetics and Gene Regulation"],"prefix":"10.3897","volume":"62","author":[{"given":"Violeta","family":"Snegarova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darina","family":"Naydenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2020,12,31]]},"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/50204\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/50204\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=50204&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T11:22:35Z","timestamp":1609413755000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/50204\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12,31]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.62.e50204.","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,31]]}}}