{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:15:24Z","timestamp":1768554924475,"version":"3.49.0"},"reference-count":0,"publisher":"Pensoft Publishers","issue":"4","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Sepsis is a significant cause of morbidity and mortality worldwide. Current clinical practice, however, lacks reliable diagnostic indicators for it and its prognosis.<\/jats:p>\n          <jats:p><jats:bold>Aim:<\/jats:bold> The present study aimed to investigate the efficacy of delta neutrophil index (DNI), which reflects the proportion of circulating immature granulocytes, in predicting infections and sepsis.<\/jats:p>\n          <jats:p><jats:bold>Materials and methods:<\/jats:bold> A prospective non-interventional single-center clinical follow-up study was performed in a Bulgarian ICU&amp;nbsp; between January 1, 2017 and May 31, 2018.&amp;nbsp; We analyzed adult patients: 45 patients met the sepsis criteria, as defined in SEPSIS-3, whereas 37 were infected patients fulfilling no criteria of sepsis. Logistic regression and Roc-curve analysis were used to evaluate the severity and prognostic value of DNI as a prediction marker in critically ill septic patients.<\/jats:p>\n          <jats:p><jats:bold>Results:<\/jats:bold> The results have shown that at DNI values of 1.4 there is 73% sensitivity and 87% specificity (AUC 0.764, 95% CI 0.650&amp;ndash;0.878, p=0.0001) to assume the presence of sepsis. Additionally, DNI was significantly associated with the severity of the condition of patients, the organ dysfunction and the IL-8 marker.<\/jats:p>\n          <jats:p><jats:bold>Conclusions:<\/jats:bold> DNI may serve as a useful marker for early diagnosis of sepsis and could support decision making process regarding its treatment at an early stage of a disease development.<\/jats:p>","DOI":"10.3897\/folmed.63.e55017","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T14:15:30Z","timestamp":1630073730000},"page":"496-501","source":"Crossref","is-referenced-by-count":6,"title":["Delta neutrophil index: in search of an early indicator of sepsis"],"prefix":"10.3897","volume":"63","author":[{"given":"Pavlina","family":"Peneva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviya","family":"Nikolova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yana","family":"Bocheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2021,8,31]]},"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/55017\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/55017\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=55017&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T14:15:31Z","timestamp":1630073731000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/55017\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,31]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.63.e55017","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}