{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:47:05Z","timestamp":1747223225797,"version":"3.40.5"},"reference-count":0,"publisher":"Pensoft Publishers","issue":"6","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Obesity creates health problems by increasing the risks of chronic diseases such as type 2 diabetes and cardiovascular disorders. Obesity leads to insulin resistance, higher blood glucose and cholesterol levels. Adipose tissues synthesize adiponectin which acts as anti-inflammatory, antidiabetic, and anti-atherogenic agent. Meanwhile, vitamin E is an antioxidant that acts as an anti-inflammation.<\/jats:p>\n          <jats:p><jats:bold>Aim:<\/jats:bold> The purpose of this study was to analyze the effects of vitamin E supplementation to metabolic markers on diet-induced obesity in mice.<\/jats:p>\n          <jats:p><jats:bold>Materials and methods:<\/jats:bold> Twenty-four mice (<jats:italic>Mus musculus, L<\/jats:italic>) aged four weeks were divided into six groups which were fed different diets and given vitamin E in different dosages or methods. The period of treatment was 18 weeks. The mice body weights were measured every week; blood sugar and cholesterol levels were measured every six weeks, and the adiponectin level measurement was done at week 18.<\/jats:p>\n          <jats:p><jats:bold>Results:<\/jats:bold> A repeated measures ANOVA showed that body weight and cholesterol level within groups were not significantly different [F(15,&amp;nbsp;54)=1.417, 0.173 and F(10,&amp;nbsp;36)=1.391, 0.224 respectively]. The glucose levels were found to be significantly different [F(7.646,&amp;nbsp;27.526)=2.625, 0.030]. There was no significant difference in the adiponectin levels.<\/jats:p>\n          <jats:p><jats:bold>Conclusions:<\/jats:bold> Vitamin E supplementation could not prevent the increase of body weight, the elevation of blood sugar and cholesterol levels, and also could not increase adiponectin level.<\/jats:p>","DOI":"10.3897\/folmed.63.e57877","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T08:32:07Z","timestamp":1640939527000},"page":"895-900","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Vitamin E Supplementation&amp;nbsp;to Metabolic Markers on Diet-Induced Obesity in Mice&amp;nbsp;"],"prefix":"10.3897","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7250-189X","authenticated-orcid":true,"given":"Eka Roina","family":"Megawati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-0057","authenticated-orcid":true,"given":"Lokot Donna","family":"Lubis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Febi Yanti","family":"Harahap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2021,12,31]]},"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/57877\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/57877\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=57877&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T08:32:07Z","timestamp":1640939527000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/57877\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,12,31]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.63.e57877","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"type":"electronic","value":"1314-2143"},{"type":"print","value":"0204-8043"}],"subject":[],"published":{"date-parts":[[2021,12,31]]}}}