{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:07:47Z","timestamp":1772489267030,"version":"3.50.1"},"reference-count":0,"publisher":"Pensoft Publishers","issue":"4","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Collagen type I is a major structural component of human uterus. Recent studies have found that collagen type I turnover is altered in preeclampsia and imbalance occurs between collagen synthesis and degradation processes. This acts as a stimulus for abnormal changes in the concentrations of collagen type I derived products in circulating blood.<\/jats:p>\n          <jats:p><jats:bold>Aim:<\/jats:bold> Having in mind the pathological collagen type I turnover in preeclampisa, the aim of the present study was to determine the levels of N-terminal propeptide of collagen type I (PINP), C-terminal propeptide of collagen type I (PICP): both markers of collagen type I synthesis and levels of matrix metalloproteinase-1 (MMP-1): marker of collagen type I degradation in sera of women with early-onset preeclampsia.<\/jats:p>\n          <jats:p><jats:bold>Materials and methods:<\/jats:bold> Thirty-two patients with early-onset preeclampsia were examined. The mean age of the patients was 28.8&amp;plusmn;5.5 years; and the mean age of 22 age-matched healthy pregnant women was 28.5&amp;plusmn;6.0 years. The enzyme-linked immunosorbent assay (ELISA) was used for measuring serum levels of PINP, PICP and MMP-1.<\/jats:p>\n          <jats:p><jats:bold>Results:<\/jats:bold> There were no statistically significant differences between levels of PINP, PICP and MMP-1 in the sera of women with preeclampsia and healthy pregnancies: 16.991 (15.41&amp;divide;21.143) vs. 17.189 (15.805&amp;divide;20.747) &amp;micro;g\/L (KW=0.02; p&gt;0.05), 10.929 (8.7&amp;divide;13.937) vs. 11.474 (7.369&amp;divide;11.932) &amp;micro;g\/L (KW=0.026; <jats:italic>p<\/jats:italic>&gt;0.05), and 2.097 (1.384&amp;divide;2.923) vs. 2.589 (1.41&amp;divide;4.533) &amp;micro;g\/L (KW=0.238; <jats:italic>p<\/jats:italic>&gt;0.05), respectively. There were statistically significantly higher number of patients from the preeclampsia group than healthy pregnant women with BMI&amp;ge;25 (23\/32 vs. 4\/22) and abnormal UAD (18\/32 vs. 2\/22) (<jats:italic>p<\/jats:italic>&lt;0.05).<\/jats:p>\n          <jats:p><jats:bold>Conclusions:<\/jats:bold> Our results did not show significant differences between serum levels of PINP, PICP and MMP-1 (markers of collagen type I turnover) in women with early-onset preeclampsia and healthy pregnancy. Further studies with more specific methods and larger sample size are required to assess changes in the serum levels of PINP, PICP and MMP-1 in early-onset preeclampsia.<\/jats:p>","DOI":"10.3897\/folmed.63.e60249","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T14:20:40Z","timestamp":1630074040000},"page":"519-526","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of serum levels of collagen type I turnover markers in early-onset preeclampsia and healthy pregnant women"],"prefix":"10.3897","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-5124","authenticated-orcid":true,"given":"Asparuh G.","family":"Nikolov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-2053","authenticated-orcid":true,"given":"Nikola K.","family":"Popovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander B.","family":"Blazhev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetla","family":"Blazheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2021,8,31]]},"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/60249\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/60249\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=60249&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T14:20:40Z","timestamp":1630074040000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/60249\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,31]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.63.e60249","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}