{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:47:22Z","timestamp":1747223242901,"version":"3.40.5"},"reference-count":19,"publisher":"Pensoft Publishers","issue":"6","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/share-your-work\/public-domain\/cc0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>Apical cysts are typically caused by dental pulp disease and are difficult to treat. In the majority of cases, surgical intervention is required. The rate of success after apical osteotomy varies between 60% and 91%. The introduction of platelet concentrates in treating chronic apical periodontitis is a promising direction for achieving quick and secure results. This article examines the healing of a sizable apical cyst after conservative surgical intervention and the application of platelet concentrate.<\/jats:p>\n          <jats:p>We present the case of a patient with a large apical cyst (0.799 cm<jats:sup>3<\/jats:sup>) of teeth 24 and 25 which was treated in this study. The precise endodontic treatment was performed with regenerative components such as gaseous ozone and EDTA irrigation. Apical osteotomy was performed, followed by inserting advanced platelet-rich fibrin plus (A-PRF+) into the surgical wound.<\/jats:p>\n          <jats:p>Nine months after treatment, the bones of teeth 24 and 25 were fully healed without any changes to the sinus and nine months after surgically removing the radicular cyst, rapid and complete tissue repair was demonstrated.<\/jats:p>","DOI":"10.3897\/folmed.65.e100418","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T19:01:45Z","timestamp":1703876505000},"page":"1005-1010","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of an apical cyst with platelet concentrate \u2013 a case report"],"prefix":"10.3897","volume":"65","author":[{"given":"Janet","family":"Kirilova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0149-4263","authenticated-orcid":true,"given":"Dimitar","family":"Kirov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-1099","authenticated-orcid":true,"given":"Dimitar","family":"Yovchev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-9932","authenticated-orcid":true,"given":"Elitsa","family":"Deliverska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"100418_B1","doi-asserted-by":"crossref","unstructured":"1. Karamifar K, Tondari A, Saghiri MA. Endodontic periapical lesion: an overview on the etiology, diagnosis and current treatment modalities. Eur Endod J 2020; 5(2):54\u201367.","DOI":"10.14744\/eej.2020.42714"},{"key":"100418_B2","doi-asserted-by":"crossref","unstructured":"2. Mead C, Javidan-Nejad S, Mego ME, et al. Levels of evidence for the outcome of endodontic surgery. J Endod 2005; 31:19\u201324.","DOI":"10.1097\/01.DON.0000133158.35394.8A"},{"key":"100418_B3","doi-asserted-by":"crossref","unstructured":"3. Wang N, Knight K, Dao T, et al. Treatment outcome in endodontics \u2013 the Toronto Study. Phases I and II: apical surgery. J Endod 2004; 30:751\u201361.","DOI":"10.1097\/01.don.0000137633.30679.74"},{"key":"100418_B4","doi-asserted-by":"crossref","unstructured":"4. Xiao X, Dai JW, Li Z, et al. Pathological fracture of the mandible caused by radicular cyst: A case report and literature review. Medicine 2018; 97:e13529.","DOI":"10.1097\/MD.0000000000013529"},{"key":"100418_B5","doi-asserted-by":"crossref","unstructured":"5. Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg 2018; 44:87\u201395.","DOI":"10.1007\/s00068-017-0767-9"},{"key":"100418_B6","doi-asserted-by":"crossref","unstructured":"6. Miron RJ, Zucchelli G, Pikos MA, et al. Use of platelet-rich fibrin in regenerative dentistry: A systematic review. Clin Oral Investig 2017; 21:1913\u201327.","DOI":"10.1007\/s00784-017-2133-z"},{"key":"100418_B7","doi-asserted-by":"crossref","unstructured":"7. Vidhale G, Jain D, Jain S, et al. Management of radicular cyst using platelet-rich fibrin and iliac bone graft \u2013 a case report. 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J Oral Implantol 2014; 40:679\u201389.","DOI":"10.1563\/aaid-joi-D-14-00138"},{"key":"100418_B14","doi-asserted-by":"crossref","unstructured":"14. Ghanaati S, Al-Maawi S, Herrera-Vizcaino C, et al. A proof of the low speed centrifugation concept in rodents: new perspectives for in vivo research. Tissue Eng Part C Methods 2018; 24:659\u201370.","DOI":"10.1089\/ten.tec.2018.0236"},{"key":"100418_B15","doi-asserted-by":"crossref","unstructured":"15. El Bagdadi K, Kubesch A, Yu X, et al. Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: A proof of concept of LSCC (low-speed centrifugation concept). Eur J Trauma Emerg Surg 2019; 45:467\u201379.","DOI":"10.1007\/s00068-017-0785-7"},{"key":"100418_B16","doi-asserted-by":"crossref","unstructured":"16. Gallar KM, Wildbiller M, Buchalla W, et al. EDTA conditioning of dentine promotes adhesion, migration and differentiation of dental pulp stem cells. Int Endod J 2016; 49:581\u201390.","DOI":"10.1111\/iej.12492"},{"key":"100418_B17","doi-asserted-by":"crossref","unstructured":"17. Grocholewicz K, Matkowska-Cichocka G, Makowiecki P, et al. Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial. Sci Rep 2020; 7:11192.","DOI":"10.1038\/s41598-020-67885-8"},{"key":"100418_B18","doi-asserted-by":"crossref","unstructured":"18. Kirilova J, Kirov D, Yovchev D, et al. Endodontic and surgical treatment of chronic apical periodontitis: a randomized clinical study. Biotechnol Biotechnol Equip 2022; 36(1):737\u201344.","DOI":"10.1080\/13102818.2022.2108338"},{"key":"100418_B19","doi-asserted-by":"crossref","unstructured":"19. Deliverska E, Kirilova J. Long-term outcome of endo-surgical treatment of chronic apical periodontitis \u2013 case reports. 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