{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:42Z","timestamp":1790281782228,"version":"4.1.0"},"reference-count":0,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>The need of biomarkers predicting the course of MTB infection, and the necessity of specific therapy, is well recognized. We measured the induced expression of effector and regulatory cytokines IFN-\u03b3, TNF-\u03b1, IL-2, IL-17, IL-6, IL-10 in relation to the lipid mediators PGE2 and LXA4 in: active TB infection (ATB, n=15) before and after therapy (ATB-T, n=6); established latent infection (LTBI, n=22), recent contacts of ATB (RC, n=12); and healthy controls (n=11) A flow cytometry microarray (CBA, BD Biosciences) and quantitative ELISA (SunRed Tech.) were employed. RC were characterized by a high potential for IL-17 and Th1 cytokine secretion, combined with low IL-6 expression, while ATB donors had a partially preserved TNF-\u03b1 potential, and higher IL-6 expression. PGE2 \/LXA4 ratio discriminated between situations with high bacterial load (ATB), and contained infection (LTBI, ATB-T), and defined clearly-cut subgroups among RC and ATB donors. Our results propose that increased PGE2\/LXA4 ratio coupled with high induced IL-10 level indicates infection after a recent contact. In the settings of ATB, increased ratio and low TNF-\u03b1 level point to inefficient granuloma formation in the settings of ATB.<\/jats:p>","DOI":"10.3897\/folmed.65.e80599","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T08:21:45Z","timestamp":1688026905000},"page":"399-406","source":"Crossref","is-referenced-by-count":4,"title":["Eicosanoid and cytokine levels differentiate between stages of MTB infection"],"prefix":"10.3897","volume":"65","author":[{"given":"Yana","family":"Todorova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-1361","authenticated-orcid":true,"given":"Radoslava","family":"Emilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Milanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-5011","authenticated-orcid":true,"given":"Elizabeta","family":"Bachiyska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliana","family":"Atanasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Baikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Nikolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2023,6,30]]},"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/80599\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/80599\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=80599&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T08:21:47Z","timestamp":1688026907000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/80599\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,6,30]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.65.e80599","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,30]]}}}