{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:36:34Z","timestamp":1787866594052,"version":"build-2784847793"},"reference-count":40,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>Ovarian tissue autotransplantation is an innovative fertility preservation technique that has provoked ongoing investigations. The purpose of the present study was to assess the safety and reproductive performance of ovarian tissue autotransplantation. This review is conducted according to PRISMA guidelines. Seven studies met the inclusion criteria. A total of 3427 patients underwent ovarian tissue cryopreservation and 205 received an autotransplantation. Tissue retrieval was mainly performed by laparoscopy and only one major complication occurred. Transplantations were predominantly performed by open procedures and data on safety were insufficient. A total of 295 autotransplantations were analyzed, resulting in 104 pregnancies. Sixty-five pregnancies led to live births, while nine were ongoing at that time. A pregnancy rate (PR) of 50.7% and a live-birth rate (LBR) of 32.7% were observed. Natural conception accounted for 46.3% of live births. No birth deficits were recorded. Ovarian tissue autotransplantation seems to be a safe procedure with acceptable pregnancy rates.<\/jats:p>","DOI":"10.3897\/folmed.65.e89198","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T16:21:29Z","timestamp":1687969289000},"page":"362-370","source":"Crossref","is-referenced-by-count":4,"title":["Safety and efficacy of ovarian tissue autotransplantation: A systematic literature review"],"prefix":"10.3897","volume":"65","author":[{"given":"Eirini","family":"Giovannopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Valeria","family":"Karakasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kouroupi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Giatromanolaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Tsikouras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Pavlidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"89198_B1","doi-asserted-by":"crossref","unstructured":"1. Nahata L, Woodruff TK, Quinn GP, et al. Ovarian tissue cryopreservation as standard of care: what does this mean for pediatric populations? J Assist Reprod Genet 2020; 37:1323.","DOI":"10.1007\/s10815-020-01794-7"},{"key":"89198_B2","doi-asserted-by":"crossref","unstructured":"2. Martinez F, Andersen CY, Barri PN, et al. Update on fertility preservation from the Barcelona International Society for Fertility Preservation-ESHRE-ASRM 2015 expert meeting: Indications, results and future perspectives. Hum Reprod 2017; 32:1802\u201311.e2.","DOI":"10.1093\/humrep\/dex218"},{"key":"89198_B3","doi-asserted-by":"crossref","unstructured":"3. Chae-Kim JJ, Gavrilova-Jordan L. Premature ovarian insufficiency: procreative management and preventive strategies. Biomedicines 2018; 7(1):2.","DOI":"10.3390\/biomedicines7010002"},{"key":"89198_B4","doi-asserted-by":"crossref","unstructured":"4. Committee of the American Society for Reproductive Medicine. Fertility preservation and reproduction in patients facing gonadotoxic therapies: an Ethics Committee opinion. Fertil Steril 2018; 110:380\u20136.","DOI":"10.1016\/j.fertnstert.2018.05.034"},{"key":"89198_B5","doi-asserted-by":"crossref","unstructured":"5. Oktay K, Karlikaya GG, Aydin BA. Ovarian cryopreservation and transplantation: Basic aspects. Mol Cell Endocrinol 2000; 169:105\u20138.","DOI":"10.1016\/S0303-7207(00)00361-0"},{"key":"89198_B6","doi-asserted-by":"crossref","unstructured":"6. Donnez J, Dolmans MM, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue.[Erratum appears in Lancet. 2004 Dec 4;364(9450):2020]. Lancet 2004; 364:1405\u201310.","DOI":"10.1016\/S0140-6736(04)17222-X"},{"key":"89198_B7","doi-asserted-by":"crossref","unstructured":"7. Von Wolff M, S\u00e4nger N, Liebenthron J. Is ovarian tissue cryopreservation and transplantation still experimental? It is a matter of female age and type of cancer. J Clin Oncol 2018; 36(33):3340-1.","DOI":"10.1200\/JCO.18.00425"},{"key":"89198_B8","doi-asserted-by":"crossref","unstructured":"8. Dolmans M-M, Falcone T, Patrizio P. Importance of patient selection to analyze in vitro fertilization outcome with transplanted cryopreserved ovarian tissue. Fertil Steril 2020; 114:279\u201380.","DOI":"10.1016\/j.fertnstert.2020.04.050"},{"key":"89198_B9","doi-asserted-by":"crossref","unstructured":"9. Moher D, Liberati A, Tetzlaff J, ADPGroup. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. - PubMed - NCBI. PLoS Med 2009; 6(7):e1000097.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"89198_B10","doi-asserted-by":"crossref","unstructured":"10. Jensen AK, Kristensen SG, Macklon KT, et al. Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark. 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Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue in a single center. Fertil Steril 2015; 103:462\u20138.","DOI":"10.1016\/j.fertnstert.2014.10.045"},{"key":"89198_B15","doi-asserted-by":"crossref","unstructured":"15. Meirow D, Ra\u2019anani H, Shapira M, et al. Transplantations of frozen-thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria. Fertil Steril 2016; 106:467\u201374.","DOI":"10.1016\/j.fertnstert.2016.04.031"},{"key":"89198_B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.11.018"},{"key":"89198_B17","doi-asserted-by":"crossref","unstructured":"17. Morgan S, Anderson RA, Gourley C, et al. How do chemotherapeutic agents damage the ovary? Hum Reprod Update 2012; 18:525\u201335.","DOI":"10.1093\/humupd\/dms022"},{"key":"89198_B18","doi-asserted-by":"crossref","unstructured":"18. Bedoschi G, Navarro PA, Oktay K. 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Fertility and hormone preservation and restoration for female children and adolescents receiving gonadotoxic cancer treatments: A systematic review. J Pediatric Surg 2019; 54:2200\u20139.","DOI":"10.1016\/j.jpedsurg.2018.12.021"},{"key":"89198_B30","doi-asserted-by":"crossref","unstructured":"30. Bedaiwy MA, El-Nashar SA, El Saman AM, et al. Reproductive outcome after transplantation of ovarian tissue: a systematic review. Hum Reprod 2008; 23(12):2709\u201317.","DOI":"10.1093\/humrep\/den301"},{"key":"89198_B31","doi-asserted-by":"crossref","unstructured":"31. Segers I, Mateizel I, Van Moer E, et al. In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising \u201cex vivo\u201d method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe. J Assist Reprod Genet 2015; 32(8):1221\u201331.","DOI":"10.1007\/s10815-015-0528-9"},{"key":"89198_B32","doi-asserted-by":"crossref","unstructured":"32. 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