{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:34:32Z","timestamp":1762432472345},"reference-count":11,"publisher":"Pensoft Publishers","issue":"1","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Introduction<\/jats:bold>: Sch\u00f6nlein-Henoch disease is a small vessel vasculitis resulting from IgA-mediated inflammation. It is the most common acute systemic vasculitis in childhood, mainly affecting the skin, gastrointestinal tract, joints, and kidneys. Although the prognosis of Sch\u00f6nlein-Henoch is generally good, gastrointestinal tract involvement is a potential complication, presenting as massive gastrointestinal bleeding, bowel infarction, perforation, as well as intussusception and peritonitis.<\/jats:p>\n          <jats:p><jats:bold>Aim<\/jats:bold>: In everyday clinical practice, determining markers of gastrointestinal tract involvement is critical when the initial or only available symptoms are related to it. Ultrasound diagnosis is effective as a first-line screening method in children with Sch\u00f6nlein-Henoch purpura and abdominal involvement, in order to objectivize changes in the small intestinal wall, such as thickening, disturbance of its stratification, and intramural bleeding.<\/jats:p>\n          <jats:p><jats:bold>Materials and methods<\/jats:bold>: Since, until recently, the generally accepted concept that there are neither coagulation disorders nor changes in the small intestinal wall\u2019s ultrasound examination has limited our understanding of the essence of Sch\u00f6nlein-Henoch disease, we looked for more trustworthy indicators.<\/jats:p>\n          <jats:p><jats:bold>Results<\/jats:bold>: These indicators, such as factor XIII and von Willebrand factor-associated antigen, showed significant deviations from the reference ranges in our study of patients with abdominal pain who had Sch\u00f6nlein-Henoch disease.<\/jats:p>\n          <jats:p><jats:bold>Conclusions<\/jats:bold>: In conclusion, early assessment of altered coagulation factors f. XIII and vWF:Ag and ultrasound monitoring of changes in the small bowel wall proved to be a valid criterion for therapeutic accuracy as well as avoiding surgical complications.<\/jats:p>","DOI":"10.3897\/folmed.66.e113993","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T13:59:10Z","timestamp":1709128750000},"page":"73-79","source":"Crossref","is-referenced-by-count":2,"title":["Modern diagnostic methods for early assessment of the abdominal involvement in Sch\u00f6nlein-Henoch disease"],"prefix":"10.3897","volume":"66","author":[{"given":"Anelia V.","family":"Vasileva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Chakarov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petranka","family":"Chakarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"113993_B1","doi-asserted-by":"crossref","unstructured":"1. Hung SP, Yang YH, Lin YT, et al. Clinical manifestations and outcomes of Henoch-Sch\u00f6nlein purpura: comparison between adults and children. Pediatr Neonatol 2009; 50:162\u20138.","DOI":"10.1016\/S1875-9572(09)60056-5"},{"key":"113993_B2","doi-asserted-by":"crossref","unstructured":"2. Rostoker G. Sch\u00f6nlein-Henoch purpura in children and adults-diagnosis, pathophysiology and management. Bio Drugs 2001; 15(2):99\u2013138.","DOI":"10.2165\/00063030-200115020-00004"},{"key":"113993_B3","doi-asserted-by":"crossref","unstructured":"3. Blanco R, Martinez-Taboada VM, Rodriguez-Velverde V, et al. Henoch-Sch\u00f6nlein purpura in adulthood and childhood: two different expressions of the same syndrome. Arthritis Rheum 1997; 40:859\u201364.","DOI":"10.1002\/art.1780400513"},{"key":"113993_B4","doi-asserted-by":"crossref","unstructured":"4. Gedalia A. Henoch-Sch\u00f6nlein purpura. Curr Rheumatol Rep 2004; 6:195\u2013202.","DOI":"10.1007\/s11926-004-0068-2"},{"key":"113993_B5","doi-asserted-by":"crossref","unstructured":"5. L\u00f3pez-Mej\u00edas R, Genre F, P\u00e9rez BS, et al. Association of HLA-B*41:02 with Henoch-Sch\u00f6nlein purpura (IgA vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status. Arthritis Res Ther 2015; 17:102.","DOI":"10.1186\/s13075-015-0622-5"},{"key":"113993_B6","doi-asserted-by":"crossref","unstructured":"6. Dalens B, Travade P, Labb\u00e9 A, et al. Diagnostic and prognostic value of fibrin stabilizing factor in Sch\u00f6nlein-Henoch syndrome. Arch Dis Child 1983; 58:12\u20134.","DOI":"10.1136\/adc.58.1.12"},{"key":"113993_B7","doi-asserted-by":"crossref","unstructured":"7. Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum 2013; 65:1\u201311.","DOI":"10.1007\/s10157-013-0869-6"},{"key":"113993_B8","doi-asserted-by":"crossref","unstructured":"8. Sporn LA, Chavin SI, Marder VJ, et al. Biosynthesis of von Willebrand protein by megakariocytes. J Clin Invest 1985; 76:1102\u20136.","DOI":"10.1172\/JCI112064"},{"key":"113993_B9","doi-asserted-by":"crossref","unstructured":"9. Shin JI, Park JM, Shin YH, et al. Can azathioprine and steroids alter the progression of severe Henoch-Sch\u00f6nlein nephritis in children? Pediatr Nephrol 2005; 20:1087\u201392.","DOI":"10.1007\/s00467-005-1869-x"},{"key":"113993_B10","doi-asserted-by":"crossref","unstructured":"10. Bombelburg T, Claasen U, Von Lengerke HJ. Intestinal ultrasonographic findings in Sch\u00f6nlein-Henoch syndrome. Eur J Pediatr 1991; 150:158\u201360.","DOI":"10.1007\/BF01963556"},{"key":"113993_B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0247-8"}],"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/113993\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/113993\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=113993&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T13:59:14Z","timestamp":1709128754000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/113993\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,29]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.66.e113993","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,29]]}}}