{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:47:43Z","timestamp":1747223263359,"version":"3.40.5"},"reference-count":11,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>In recent years, the role of radiation oncology in treating various pediatric cancers has been extensively researched and developed. The dosage of radiotherapy, when combined with chemotherapy, was either reduced in some oncological diseases or modified in other cancers. Despite these changes, due to swift advancements in radiation oncology technology, this combination therapy continues to enhance both overall and progression-free survival rates, maintaining its vital status as a therapeutic approach in precision medicine.<\/jats:p>\n          <jats:p>We report here a nine-year-old patient with nasopharyngeal carcinoma treated according to SIOPE guidelines, which included induction neoadjuvant chemotherapy followed by concurrent chemoradiotherapy with cisplatin. Post-therapy imaging assessments revealed a persistent tumor mass with reduced dimensions on MRI one month after treatment, characterized by absence of contrast enhancement, water diffusion restriction, or lymphadenopathy. Subsequent CT imaging at three months post-radiotherapy showed no signs of disease progression. Repeat MRI scans at four and six months post-treatment demonstrated stable disease without evidence of water diffusion restriction, indicating a positive response to therapy. These results underscore the effectiveness of the multimodal approach in achieving favorable tumor control and therapeutic efficacy in pediatric nasopharyngeal carcinoma.<\/jats:p>","DOI":"10.3897\/folmed.66.e122593","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T11:24:35Z","timestamp":1719919475000},"page":"421-425","source":"Crossref","is-referenced-by-count":0,"title":["A nine-year-old child with nasopharyngeal cancer treated with concomitant chemoradiotherapy with cisplatin \u2013 a case report"],"prefix":"10.3897","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-9665","authenticated-orcid":true,"given":"Veselin","family":"Popov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulhan","family":"Suleyman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-2989","authenticated-orcid":true,"given":"Neofit","family":"Spasov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Pavlov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Raycheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"122593_B1","doi-asserted-by":"crossref","unstructured":"1. Ayan I, Kaytan E, Ayan N. Childhood nasopharyngeal carcinoma: from biology to treatment. Lancet Oncol 2003; 4:13\u201321.","DOI":"10.1016\/S1470-2045(03)00956-2"},{"key":"122593_B2","unstructured":"2. Deutsch M, Mercado Jr R, Parsons JA. Cancer of the nasopharynx in children. Orphanet J Rare D 2006; 1:23."},{"key":"122593_B3","doi-asserted-by":"crossref","unstructured":"3. Ingersoll L, Woo SY, Donaldson S, et al. Nasopharyngeal carcinoma in the young: a combined M.D. Anderson and Stanford experience. Int J Radiat Oncol Biol Phys 1990; 19:881\u20137.","DOI":"10.1016\/0360-3016(90)90008-8"},{"key":"122593_B4","doi-asserted-by":"crossref","unstructured":"4. Vokes EE, Liebowitz DN, Weichselbaum RR. Nasopharyngeal carcinoma. Lancet 1997; 350:1087\u201391.","DOI":"10.1016\/S0140-6736(97)07269-3"},{"key":"122593_B5","doi-asserted-by":"crossref","unstructured":"5. Wolf H, Hausen H, Becker V. EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nat New Biol 1973; 244:245\u20137.","DOI":"10.1038\/newbio244245a0"},{"key":"122593_B6","doi-asserted-by":"crossref","unstructured":"6. Cvitkovic E, Bachouchi M, Armand JP. Nasopharyngeal carcinoma. Biology, natural history, and therapeutic implications. Hematol Oncol Clin North Am 1991; 5:821\u201338.","DOI":"10.1016\/S0889-8588(18)30418-0"},{"key":"122593_B7","doi-asserted-by":"crossref","unstructured":"7. Ayan I, Altun M. Nasopharyngeal carcinoma in children: retrospective review of 50 patients. Int J Radiat Oncol Biol Phys 1996; 35:485\u201392.","DOI":"10.1016\/S0360-3016(96)80010-1"},{"key":"122593_B8","doi-asserted-by":"crossref","unstructured":"8. Guo Q, Cui X, Lin S, et al. Locoregionally advanced nasopharyngeal carcinoma in childhood and adolescence: Analysis of 95 patients treated with combined chemotherapy and intensity\u2010modulated radiotherapy. Head Neck 2015; 38(S1):E665\u201372.","DOI":"10.1002\/hed.24066"},{"key":"122593_B9","doi-asserted-by":"crossref","unstructured":"9. Al-Sarraf M, LeBlanc M, Giri PG, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998; 16:1310\u20137.","DOI":"10.1200\/JCO.1998.16.4.1310"},{"key":"122593_B10","doi-asserted-by":"crossref","unstructured":"10. Mertens R, Granzen B, Lassay L, et al. Nasopharyngeal carcinoma in childhood and adolescence: concept and preliminary results of the cooperative GPOH study NPC-91. Gesellschaft f\u00fcr P\u00e4diatrische Onkologie und H\u00e4matologie. 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