{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T18:42:14Z","timestamp":1775760134845,"version":"3.50.1"},"reference-count":11,"publisher":"Pensoft Publishers","issue":"5","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>COVID-19 presents with respiratory symptoms and signs in the majority of cases. The central nervous system can be affected directly or indirectly, which is demonstrated by a number of neurological abnormalities and complications. The aim of this study is to present a clinical case of SARS-CoV-2-associated encephalitis and highlight the severity of this neurological illness over the course of COVID-19. Etiological diagnosis methods include examination of the nasopharyngeal swab and cerebrospinal fluid by PCR.<\/jats:p>\n          <jats:p>A 45-year-old man with fever, altered consciousness, and tonic-clonic seizures was admitted to the Clinic of Infectious Diseases, St George University Hospital, Plovdiv. The diagnosis of COVID-19 encephalitis is based on typical clinical and laboratory data, positive SARS-CoV-2 PCR, and exclusion of other likely causative agents into the cerebrospinal fluid. The patient was discharged two weeks after admission without neurological sequelae. The case confirms the clinical variety of COVID-19 and the possibility of severe neurological manifestations. Encephalitis is a rare but potentially life-threatening condition. Physicians should be aware of encephalitis in SARS-CoV-2 patients with neurological symptoms.<\/jats:p>","DOI":"10.3897\/folmed.66.e124015","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T15:48:19Z","timestamp":1730908099000},"page":"743-748","source":"Crossref","is-referenced-by-count":1,"title":["SARS-CoV-2-associated encephalitis: a case report"],"prefix":"10.3897","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2223-9058","authenticated-orcid":true,"given":"Petya","family":"Argirova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Todev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-6799","authenticated-orcid":true,"given":"Yordan","family":"Kalchev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Zlatanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariyana","family":"Stoycheva-Vartigova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"124015_B1","doi-asserted-by":"crossref","unstructured":"1. 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Immune-mediated neurological syndrome in SARS-CoV-2 infection: a review of literature on autoimmune encephalitis in COVID-19. Neurol Sci 2022; 43(3):1533\u201347.","DOI":"10.1007\/s10072-021-05785-z"},{"key":"124015_B5","doi-asserted-by":"crossref","unstructured":"5. Nabizadeh F, Balabandian M, Sodeifian F, et al. Autoimmune encephalitis associated with COVID-19: A systematic review. Mult Scler Relat Disord 2022; 62:103795.","DOI":"10.1016\/j.msard.2022.103795"},{"key":"124015_B6","doi-asserted-by":"crossref","unstructured":"6. Huo L, Xu K, Wang H. Clinical features of SARS-CoV-2-associated encephalitis and meningitis amid COVID-19 pandemic. World J Clin Cases 2021; 9(5):1058\u201378.","DOI":"10.12998\/wjcc.v9.i5.1058"},{"key":"124015_B7","doi-asserted-by":"crossref","unstructured":"7. Mondal R, Ganguly U, Deb S, et al. Meningoencephalitis associated with COVID-19: a systematic review. J Neurovirol 2021; 27(1):12\u201325.","DOI":"10.1007\/s13365-020-00923-3"},{"key":"124015_B8","doi-asserted-by":"crossref","unstructured":"8. Domingues R, Leite F, Senne C. Cerebrospinal fluid analysis in patients with COVID-19-associated central nervous system manifestations: a systematic review. Arq Neuropsiquiatr 2022; 80(3):296\u2013305.","DOI":"10.1590\/0004-282x-anp-2021-0117"},{"key":"124015_B9","doi-asserted-by":"crossref","unstructured":"9. Islam M, Cavestro C, Alam S, et al. Encephalitis in patients with COVID-19: a systematic evidence-based analysis. Cells 2022; 11(16):2575.","DOI":"10.3390\/cells11162575"},{"key":"124015_B10","doi-asserted-by":"crossref","unstructured":"10. Garg R, Paliwal V, Gupta A. Encephalopathy in patients with COVID-19: A review. J Med Virol 2021; 93(1):206\u201322.","DOI":"10.1002\/jmv.26207"},{"key":"124015_B11","doi-asserted-by":"crossref","unstructured":"11. Varatharaj A, Thomas N, Ellul M, et al. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. 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