{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:46:57Z","timestamp":1753894017141,"version":"3.41.2"},"reference-count":40,"publisher":"Pensoft Publishers","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Introduction<\/jats:bold>: Androgenetic alopecia (AGA), the predominant form of hair loss, affects a significant global population. While emerging research suggests a potential correlation between serum vitamin D levels and AGA severity, the current body of evidence remains inconclusive, necessitating further investigation to elucidate this relationship and its clinical implications.<\/jats:p>\n          <jats:p><jats:bold>Objective<\/jats:bold>: To evaluate serum vitamin D levels in AGA patients and explore their relationship with the condition\u2019s severity.<\/jats:p>\n          <jats:p><jats:bold>Materials and methods<\/jats:bold>: A seven-month prospective case-control study was carried out in Pakistan. Male participants aged 18-30 yeas were divided into AGA patients and matched controls. AGA severity was assessed using the Norwood-Hamilton classification, and serum vitamin D levels were measured via radioimmunoassay. Statistical analysis included chi-squared, Fisher\u2019s exact, and unpaired t tests.<\/jats:p>\n          <jats:p><jats:bold>Results<\/jats:bold>: Patients with AGA had significantly lower sun exposure and higher rates of vitamin D deficiency (84% vs. 22%, p&amp;lt;0.0001) compared to controls. These patients had a higher BMI (24.68\u00b13.18 vs. 22.89\u00b12.80, p=0.0035). Their serum vitamin D levels were significantly lower in patients (45.64\u00b129.99 nmol\/L) than controls (91.93\u00b130.55 nmol\/L, p&amp;lt;0.0001). A strong association was found between vitamin D deficiency and AGA (p&amp;lt;0.001). Vitamin D levels correlated with the severity of AGA, and ROC analysis showed high diagnostic accuracy (AUC=0.89, p&amp;lt;0.0001).<\/jats:p>\n          <jats:p><jats:bold>Conclusion<\/jats:bold>: Serum vitamin D levels show a significant inverse association with AGA, with substantially lower concentrations and higher deficiency rates in patients compared to controls. The observed correlation between vitamin D levels and AGA severity suggests potential therapeutic implications for vitamin D supplementation in the management of AGA.<\/jats:p>","DOI":"10.3897\/folmed.67.e138514","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T12:53:27Z","timestamp":1740401607000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum Vitamin D levels in males with premature androgenetic alopecia: a prospective case-control study"],"prefix":"10.3897","volume":"67","author":[{"given":"Rehana","family":"Batool","sequence":"first","affiliation":[{"name":"Pakistan Navy Ship Shifa Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seemab","family":"Khan","sequence":"additional","affiliation":[{"name":"Pakistan Navy Ship Shifa Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hur","family":"Abbas","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-6120","authenticated-orcid":true,"given":"Syed Muhammad","family":"Abbas","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirza Shaheer","family":"Hyder","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Arbab","family":"Shah","sequence":"additional","affiliation":[{"name":"Pakistan Navy Ship Shifa Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-9852","authenticated-orcid":true,"given":"Muhammad Raza","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"Allied Hospital, Faisalabad Medical University, Faisalabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humera","family":"Fiaz","sequence":"additional","affiliation":[{"name":"National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"138514_B1","unstructured":"Al Aboud AM, Zito PM. 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