{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:46:57Z","timestamp":1753894017351,"version":"3.41.2"},"reference-count":13,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>Small cell carcinoma is a disease mainly of pulmonary origin, but in extremely rare cases it can also be observed as a primary mediastinal mass. Here, we present the case of a 48-year-old male patient with a clinical manifestation of superior vena cava syndrome and a CT scan showing a tumor mass in the upper mediastinum compressing the major vessels. A surgical intervention was performed \u2013 videomedistinoscopy with partial excision of the tumor from which primary small cell neuroendocrine carcinoma of the mediastinum was detected during histological and immunohistochemical analysis. Multimodal treatment was administered, and after the surgical intervention, the patient was treated with chemotherapy and radiotherapy. The patient was actively monitored, and 8 months after diagnosis, there was a lack of persistent symptoms. From the monitoring PET\/CT scan, a minimal single focus with metabolic activity in the mediastinum was observed with significant reduction in tumor size and lack of compression on the mediastinal vessels.<\/jats:p>","DOI":"10.3897\/folmed.67.e139306","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T14:45:04Z","timestamp":1750085104000},"source":"Crossref","is-referenced-by-count":0,"title":["Transcervical resection of primary small cell carcinoma of the mediastinum \u2013 a rare case of thoracic malignancy"],"prefix":"10.3897","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4230-5357","authenticated-orcid":true,"given":"Ivoslav","family":"Ivanov","sequence":"first","affiliation":[{"name":"Heart and Brain Hospital, Burgas, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-175X","authenticated-orcid":true,"given":"Dimo","family":"Mitev","sequence":"additional","affiliation":[{"name":"Heart and Brain Hospital, Burgas, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"139306_B1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2016.58505"},{"key":"139306_B2","doi-asserted-by":"crossref","unstructured":"2. Kang MK, Kang DK, Hwang YH. Mediastinal primary small cell neuroendocrine carcinoma-life threatening condition. Oxf Med Case Reports 2020; 2020(2):omz146.","DOI":"10.1093\/omcr\/omz146"},{"key":"139306_B3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4873"},{"key":"139306_B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.10.063"},{"key":"139306_B5","doi-asserted-by":"crossref","unstructured":"5. Kyriakopoulos G, Mavroeidi V, Chatzellis E, et al. Histopathological, immunohistochemical, genetic and molecular markers of neuroendocrine neoplasms. Ann Transl Med 2018; 6(12):252.","DOI":"10.21037\/atm.2018.06.27"},{"key":"139306_B6","doi-asserted-by":"crossref","unstructured":"6. Chaer R, Massad MG, Evans A, et al. Primary neuroendocrine tumors of the thymus. Ann Thorac Surg 2002; 74(5):1733\u201340.","DOI":"10.1016\/S0003-4975(02)03547-6"},{"key":"139306_B7","unstructured":"7. Higdon ML, Higdon JA. Treatment of oncologic emergencies. Am Fam Physician 2006; 74(11):1873\u201380."},{"key":"139306_B8","doi-asserted-by":"crossref","unstructured":"8. Rice TW, Rodriguez RM, Light RW. The superior vena cava syndrome: clinical characteristics and evolving etiology. Medicine 2006; 85:37\u201342.","DOI":"10.1097\/01.md.0000198474.99876.f0"},{"key":"139306_B9","doi-asserted-by":"crossref","unstructured":"9. Montero-Hadjadje M, Vaingankar S, Elias S, et al. Chromogranins A and B and secretogranin II: evolutionary and functional aspects. Acta Physiol 2008; 192:309\u2013324.","DOI":"10.1111\/j.1748-1716.2007.01806.x"},{"key":"139306_B10","doi-asserted-by":"crossref","unstructured":"10. Yamashita A, Marutsuka K, Moriguchi S, et al. Neuroendocrine carcinoma of the posterior mediastinum arising from a foregut cyst. Pathol Int 2005; 55:285\u2013289.","DOI":"10.1111\/j.1440-1827.2005.01826.x"},{"key":"139306_B11","doi-asserted-by":"crossref","unstructured":"11. Yajima A, Toki T, Morinaga S, et al. A retroperitoneal endocrine carcinoma. Cancer 1984; 54:2040\u20132042.","DOI":"10.1002\/1097-0142(19841101)54:9<2040::AID-CNCR2820540944>3.0.CO;2-0"},{"key":"139306_B12","doi-asserted-by":"publisher","DOI":"10.1148\/rg.261055057"},{"key":"139306_B13","unstructured":"13. Petrov D, Kostadinov D. Invasive techniques for mediastinal staging in lung cancer. Learning Textbook 2010\u2013 First National Oncologic Conference MORE. 2010:35-41."}],"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/139306\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/139306\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=139306&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T14:45:06Z","timestamp":1750085106000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/139306\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,16]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.67.e139306","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"type":"electronic","value":"1314-2143"},{"type":"print","value":"0204-8043"}],"subject":[],"published":{"date-parts":[[2025,6,16]]},"article-number":"e139306"}}