{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:29:38Z","timestamp":1755793778082,"version":"3.44.0"},"reference-count":19,"publisher":"Pensoft Publishers","issue":"4","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Aim<\/jats:bold>: Given the documented rise in the incidence and prevalence of gout over the past decade, this study aims to comparatively assess patients of different ages affected by gout in Romania and the Republic of Moldova.<\/jats:p>\n          <jats:p><jats:bold>Material and methods<\/jats:bold>: This cross-sectional observational study selectively included 490 patients with gout treated in the Republic of Moldova and Romania<\/jats:p>\n          <jats:p><jats:bold>Results<\/jats:bold>: In Romania, the study included 15 women (6.1%) and 230 men (93.9%) (mean age 52.24\u00b11.18 years). The mean age of gout onset in these patients was 42.5\u00b10.89 years. In the Republic of Moldova, 26 women (10.6%) and 219 men (89.4%) were included (mean age 49.2\u00b11.05 years), with mean age of gout onset 47.6\u00b10.52 years. Of Romanian patients, 29 (11.8%) had chronic intermittent gout with a primary attack, 42 (17.2%) had repeated attacks, and 174 (71%) had chronic tophaceous gout. In the Republic of Moldova, there were 11 (4.5%) patients with chronic intermittent gout and a primary attack, 28 (11.5%) patients with repeated attacks, and 206 (84%) patients with chronic tophaceous gout. Hereditary predisposition was observed in six (2.5%) patients in Romania and nine (3.8%) patients in the Republic of Moldova, most frequently among family members such as fathers, brothers, and uncles.<\/jats:p>\n          <jats:p><jats:bold>Conclusions<\/jats:bold>: The study reveals similarities and differences between patient\u2019s from Romania and the Republic of Moldova in terms of prevalence, clinical evolution and hereditary predisposition of gout, underlining the need for a tailor-made approach in the management of this disease.<\/jats:p>","DOI":"10.3897\/folmed.67.e147838","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T06:34:48Z","timestamp":1755239688000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of clinical characteristics of gout patients"],"prefix":"10.3897","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-3426","authenticated-orcid":true,"given":"Larisa","family":"Rotaru","sequence":"first","affiliation":[{"name":"Nicolae Testemi\u0163anu State University of Medicine and Pharmacy, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-6181","authenticated-orcid":true,"given":"Liliana","family":"Groppa","sequence":"additional","affiliation":[{"name":"Nicolae Testemi\u0163anu State University of Medicine and Pharmacy, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-8471","authenticated-orcid":true,"given":"Eugeniu","family":"Russu","sequence":"additional","affiliation":[{"name":"Nicolae Testemi\u0163anu State University of Medicine and Pharmacy, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-7188","authenticated-orcid":true,"given":"Svetlana","family":"Agachi","sequence":"additional","affiliation":[{"name":"Nicolae Testemi\u0163anu State University of Medicine and Pharmacy, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-9801","authenticated-orcid":true,"given":"Larisa","family":"Spinei","sequence":"additional","affiliation":[{"name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9802-0290","authenticated-orcid":true,"given":"Ludmila","family":"Negru\u021ba","sequence":"additional","affiliation":[{"name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-2884","authenticated-orcid":true,"given":"Emil","family":"Ceban","sequence":"additional","affiliation":[{"name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-436X","authenticated-orcid":true,"given":"Alexandru","family":"Corlateanu","sequence":"additional","affiliation":[{"name":"Nicolae Testemi\u021banu State University of Medicine and Pharmacy, Chisinau, Moldova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0175-2645","authenticated-orcid":true,"given":"Cristina","family":"Pamfil","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sprincean","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3859-5594","authenticated-orcid":true,"given":"Cornelia","family":"Cornea","sequence":"additional","affiliation":[{"name":"Timofei Mo\u0219neaga Republican Clinical Hospital, Chi\u0219in\u0103u, Moldova, Republic of"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"147838_B1","unstructured":"1. Rotaru L. [Gout: new advances in the diagnosis and management of an old disease]. Chi\u0219in\u0103u: Editura Garomont-Studio SRL. 2022; ISBN 978-9975-162-16-6 [Romanian]."},{"key":"147838_B2","doi-asserted-by":"publisher","DOI":"10.31688\/ABMU.2022.57.4.04"},{"key":"147838_B3","doi-asserted-by":"crossref","unstructured":"3. Rotaru L, Groppa L, Russu E, et al. Analysis of the economic-financial efficiency of gout treatment in elderly patients with comorbidities in the Republic of Moldova. Mediterr J Rheumatol 2023; 34(3):327\u201331.","DOI":"10.31138\/mjr.20230725.ao"},{"key":"147838_B4","doi-asserted-by":"publisher","DOI":"10.3897\/folmed.65.e91075"},{"key":"147838_B5","doi-asserted-by":"publisher","DOI":"10.31688\/ABMU.2022.57.4.04"},{"key":"147838_B6","unstructured":"6. Rotaru L, Groppa L, Ceban E, et al. Gout and renal dysfunction. In: Perspectives of the Balkan medicine in the post COVID-19 era: The 37th Balkan Medical Week. The 8th congress on urology, dialysis and kidney transplant from the Republic of Moldova \u201cNew Horizons in Urology\u201d; 2023 June 7-9; Chi\u015fin\u0103u. Bucure\u0219ti: Balkan Medical Union; 2023. p. 170. (Edi\u021bia 37). Print ISSN: 1584-9244; Online ISSN: 2558-815X."},{"key":"147838_B7","doi-asserted-by":"publisher","DOI":"10.37897\/RJR.2022.3.3"},{"key":"147838_B8","doi-asserted-by":"publisher","DOI":"10.52645\/MJHS.2023.1.04"},{"key":"147838_B9","unstructured":"9. Rotaru L, Groppa L, Russu E, et al. Gout and comorbidity. In: Abstract Book, World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases 2023 (pp. 427-427)."},{"key":"147838_B10","doi-asserted-by":"crossref","unstructured":"10. Rotaru L, Groppa L, Sarbu O. [Metabolic syndrome in patients with gout]. Revue du Rhumatisme 2016; 83: A192-A193. ISSN: 1169-8330 [French].","DOI":"10.1016\/S1169-8330(16)30479-3"},{"key":"147838_B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0890-9"},{"key":"147838_B12","doi-asserted-by":"publisher","DOI":"10.3389\/FMED.2022.1039230\/BIBTEX"},{"key":"147838_B13","doi-asserted-by":"publisher","DOI":"10.1016\/J.SEMARTHRIT.-2020.04.008"},{"key":"147838_B14","doi-asserted-by":"publisher","DOI":"10.1093\/RHEUMATOLOGY\/KEZ476"},{"key":"147838_B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2022.04.022"},{"key":"147838_B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2021.04.009"},{"key":"147838_B17","unstructured":"17. Yu Y, Wang D, Zhou Q, et al. Recommendations in clinical practice guidelines on gout: systematic review and consistency analysis. 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