{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:47:00Z","timestamp":1753894020952,"version":"3.41.2"},"reference-count":35,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p><jats:bold>Introduction<\/jats:bold>: Chronic kidney disease is characterized by the damage or dysfunction of the kidneys for a duration of at least three months, depending on its cause. End-stage kidney disease is defined by a glomerular filtration rate (GFR) of less than 15 mL\/min\/1.73 m<jats:sup>2<\/jats:sup> or the need for long-term renal replacement therapy irrespective of GFR.<\/jats:p>\n          <jats:p><jats:bold>Aim<\/jats:bold>: The aim of this study was to evaluate the impact of sex on the uric acid, albumin, urea, and creatinine levels, and the prevalence of hyperuricemia in end-stage renal disease patients.<\/jats:p>\n          <jats:p><jats:bold>Materials and methods<\/jats:bold>: This cross-sectional study was conducted at Al-Hakeem General Hospital in Al-Najaf, Iraq, from October 2023 to April 2024. The study included 50 patients with chronic renal failure or end-stage renal disease. The following data were collected for each patient: age, sex, cause of end-stage disease, duration of dialysis, number of sessions, and adequacy of dialysis. In addition, biochemical markers were analyzed.<\/jats:p>\n          <jats:p><jats:bold>Results<\/jats:bold>: The study demonstrated that 35 patients (20 male and 15 female) had hyperuricemia, a condition characterized by elevated uric acid levels in the blood. A statistically significant difference was observed between male and female patients, with male patients demonstrating considerably higher uric acid levels compared to their female counterparts. Additionally, a statistically significant difference (<jats:italic>p<\/jats:italic>&amp;lt;0.05) was observed between hyperuricemic and normouricemic groups, indicating an increase in the mean levels of serum urea, albumin, and uric acid in the hyperuricemia patients when compared with the normouricemic patients.<\/jats:p>\n          <jats:p><jats:bold>Conclusion<\/jats:bold>: Hyperuricemia was highly prevalent in end-stage renal disease patients. Patients with hyperuricemia had significantly higher serum albumin levels than those without, and a significant positive correlation was found between uric acid and blood glucose levels in the hyperuricemic group.<\/jats:p>","DOI":"10.3897\/folmed.67.e152461","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T07:36:58Z","timestamp":1747381018000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the impact of sex on some biochemical markers in end-stage renal disease patients on hemodialysis (comparison between hyperuricemia and normouricemia)"],"prefix":"10.3897","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-3976","authenticated-orcid":true,"given":"Rawaa","family":"Shareef","sequence":"first","affiliation":[{"name":"University of Kufa, Kufa, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashaer","family":"Muhammad-Baqir","sequence":"additional","affiliation":[{"name":"University of Kufa, Kufa, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-293X","authenticated-orcid":true,"given":"Evan","family":"Hameed","sequence":"additional","affiliation":[{"name":"University of Kufa, Kufa, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Al-Sader Teaching hospital, Kufa, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"doi-asserted-by":"publisher","key":"152461_B1","DOI":"10.5281\/zenodo.8312881"},{"doi-asserted-by":"crossref","unstructured":"2. 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