{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:48:42Z","timestamp":1782805722504,"version":"3.54.5"},"reference-count":20,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>Gastric diffuse large B-cell lymphoma (DLBCL) comprises most of all gastrointestinal lymphomas, accounting for approximately 55%\u201365% of all cases. This condition predominantly affects male patients and those older than 50 years and is usually aggressive. The clinical presentations are nonspecific and can mimic other diseases. In this report, we present a case of a 66-year-old male patient with a history of hematemesis and melena, with significant weight loss for 3 months. Esophagogastroduodenoscopy (EGD) revealed multiple stomach ulcers. A biopsy taken during EGD, which was followed by immunohistochemical staining, confirmed the diagnosis of non-Hodgkin lymphoma, specifically germinal center B-cell (GCB)\u2013subtype DLBCL. A positron emission tomography (PET) scan was performed, revealing the involvement of the mesenteric lymph nodes and an infiltrative lesion that extended from the stomach to the pancreas. Based on the Ann Arbor staging system, the diagnosis was identified to be stage IV gastric DLBCL. Following diagnosis, we administered rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (R-CHOP) to the patient.<\/jats:p>","DOI":"10.3897\/folmed.68.e155005","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:36:33Z","timestamp":1782804993000},"source":"Crossref","is-referenced-by-count":0,"title":["Gastric DLBCL presenting as multiple gastric ulcers: a case report"],"prefix":"10.3897","volume":"68","author":[{"given":"Wulyo","family":"Rajabto","sequence":"first","affiliation":[{"name":"Division of Haematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lugyanti","family":"Sukrisman","sequence":"additional","affiliation":[{"name":"Division of Haematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo General Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes Stephanie","family":"Harahap","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Cipto Mangunkusumo Hospital\/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pyrhadistya","sequence":"additional","affiliation":[{"name":"Emergency Department, Harapan Jayakarta General Hospital, Jakarta, Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainun","family":"Safitri","sequence":"additional","affiliation":[{"name":"Medical Education Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"155005_B1","doi-asserted-by":"crossref","unstructured":"Ju\u00e1rez-Salcedo LM, Sokol L, Chavez JC, et al. Primary gastric lymphoma, epidemiology, clinical diagnosis, and treatment. Cancer Control 2018; 25(1):1073274818778256.","DOI":"10.1177\/1073274818778256"},{"key":"155005_B2","doi-asserted-by":"crossref","unstructured":"Couto ME, Oliveira I, Domingues N, et al. Gastric diffuse large B-cell lymphoma: a single-center 9-year experience. Indian J Hematol Blood Transf 2021; 37(3):492.","DOI":"10.1007\/s12288-020-01391-9"},{"key":"155005_B3","unstructured":"Herlevic V, Reynolds SB, Morris JD. Gastric lymphoma [Internet]. 2024 [cited 2025 May 18]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK567799\/."},{"key":"155005_B4","doi-asserted-by":"crossref","unstructured":"Diamantidis MD, Papaioannou M, Hatjiharissi E. Primary gastric non-Hodgkin lymphomas: Recent advances regarding disease pathogenesis and treatment. 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Cancer Med 2023; 12(6):6924.","DOI":"10.1002\/cam4.5486"},{"key":"155005_B8","doi-asserted-by":"crossref","unstructured":"Suh BJ. A case of malignant gastrointestinal stromal tumor initially misdiagnosed as malignant B-cell lymphoma. Case Rep Oncol 2016; 9(2):344.","DOI":"10.1159\/000447352"},{"key":"155005_B9","doi-asserted-by":"crossref","unstructured":"Yamaguchi T, Takahashi H, Kagawa R, et al. Synchronous mucosa-associated lymphoid tissue lymphoma and gastrointestinal stromal tumor of the stomach presenting with gastric bleeding. Am Surg 2008; 74(3):232\u20134.","DOI":"10.1177\/000313480807400311"},{"key":"155005_B10","unstructured":"Li X. Pitfalls in the pathological diagnosis of lymphoma. Chin Clin Oncol 2015; 4(1):3\u20133."},{"key":"155005_B11","doi-asserted-by":"crossref","unstructured":"Zizhen Z, Hui C, Yanying S, et al. Correlation between immunophenotype classification and clinicopathological features in Chinese patients with primary gastric diffuse large B-cell lymphoma. 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Pathol Int 2016; 66(8):444\u201352.","DOI":"10.1111\/pin.12439"},{"key":"155005_B15","doi-asserted-by":"crossref","unstructured":"Kim B, Oh SY, Lee S, et al. Unusual presentation of large B cell lymphoma - bone and stomach - treated with autologous transplantation. Cancer Res Treat 2007; 39(4):181.","DOI":"10.4143\/crt.2007.39.4.181"},{"key":"155005_B16","doi-asserted-by":"crossref","unstructured":"Gao F, Wang ZF, Tian L, et al. A prognostic model of gastrointestinal diffuse large B cell lymphoma. Med Sci Monit 2021; 27:e929898-1.","DOI":"10.12659\/MSM.929898"},{"key":"155005_B17","doi-asserted-by":"crossref","unstructured":"Tilly H, Morschhauser F, Sehn LH, et al. Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma. NEJM 2022; 386(4):351\u201363.","DOI":"10.1056\/NEJMoa2115304"},{"key":"155005_B18","doi-asserted-by":"crossref","unstructured":"Nastoupil LJ, Bartlett NL. Navigating the evolving treatment landscape of diffuse large B-cell lymphoma. 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