{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:47:54Z","timestamp":1788353274205,"version":"build-2803163510"},"reference-count":14,"publisher":"Pensoft Publishers","issue":"4","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Introduction<\/jats:bold>\n                    : Colorectal cancer is a leading cause of morbidity and mortality worldwide. Immunoscore provides important prognostic information in early-stage colorectal cancer, beyond traditional TNM staging.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim<\/jats:bold>\n                    : To investigate the Immunoscore in early-stage colorectal cancer and its prognostic value.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods<\/jats:bold>\n                    : A retrospective pilot cohort of 35 patients was evaluated for recurrence, survival, toxicity, and clinical correlations with Immunoscore.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : High Immunoscore was associated with better outcomes, including zero recurrence. Immunoscore showed trends by tumor location, with stronger associations in younger patients. There was no correlation with carcinoembryonic antigen levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : Our findings support the incorporation of Immunoscore into future colorectal cancer staging models.\n                  <\/jats:p>","DOI":"10.3897\/folmed.68.e163476","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:15:23Z","timestamp":1785996923000},"source":"Crossref","is-referenced-by-count":1,"title":["Immunoscore as a prognostic marker in colorectal cancer"],"prefix":"10.3897","volume":"68","author":[{"given":"Yanislav Grishev","family":"Iliev","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Pulmed University Hospital, Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir Nikolov","family":"Andonov","sequence":"additional","affiliation":[{"name":"Second Department of Internal Diseases, Section of Gastroenterology, Medical University of Plovdiv, Plovdiv, Bulgaria"},{"name":"Kaspela University Hospital, Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Galabova","family":"Poryazova-Markova","sequence":"additional","affiliation":[{"name":"Department of General and Clinical Pathology, Medical University of Plovdiv, Plovdiv, Bulgaria"},{"name":"Pulmed University Hospital, Plovdiv, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"163476_B1"},{"key":"163476_B2","unstructured":"Stepien M, Rodriguez Rasero F, Nicholl C, et al. Beating cancer inequalities in the EU: spotlight on cancer prevention and early detection. Luxembourg: Publications Office of the European Union; 2023."},{"key":"163476_B3","unstructured":"European Commission, Joint Research Centre (JRC). ECIS - European Cancer Information System. Cancer Factsheets in EU-27 countries \u2013 2020. [Internet]. Luxembourg: Publications Office of the European Union; 2020 [cited 2026 March 23]. Available from: https:\/\/ecis.jrc.ec.europa.eu\/explorer.php."},{"key":"163476_B4","doi-asserted-by":"crossref","unstructured":"Pag\u00e8s F, Mlecnik B, Marliot F, et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet 2018; 391(10135):2128\u201339.","DOI":"10.1016\/S0140-6736(18)30789-X"},{"key":"163476_B5","doi-asserted-by":"crossref","unstructured":"Salama P, Phillips M, Grieu F, et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009; 27(2):186\u201392.","DOI":"10.1200\/JCO.2008.18.7229"},{"key":"163476_B6","unstructured":"Becht E, Giraldo NA, Germain C, et al. Immune contexture, immunoscore, and the changing paradigm of cancer classification. Cancer Immunol Res 2016; 4(10):744\u2013753."},{"key":"163476_B7","doi-asserted-by":"crossref","unstructured":"Mlecnik B, Bindea G, Kirilovsky A, et al. The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Sci Transl Med 2016; 8(327):327ra26.","DOI":"10.1126\/scitranslmed.aad6352"},{"key":"163476_B8","doi-asserted-by":"crossref","unstructured":"Pages F, Galon J, Dieu-Nosjean MC, et al. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2010; 29(8):1093\u2013102.","DOI":"10.1038\/onc.2009.416"},{"key":"163476_B9","doi-asserted-by":"crossref","unstructured":"Angell H, Galon J. From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer. Curr Opin Immunol 2013; 25(2):261\u20137.","DOI":"10.1016\/j.coi.2013.03.004"},{"key":"163476_B10","doi-asserted-by":"crossref","unstructured":"Galon J, Mlecnik B, Bindea G, et al. Towards the introduction of the Immunoscore in the classification of malignant tumors. J Pathol 2014; 232(2):199\u2013209.","DOI":"10.1002\/path.4287"},{"key":"163476_B11","doi-asserted-by":"crossref","unstructured":"Sinicrope FA, Shi Q, Hermitte F, et al. Immunoscore: A novel immunologic classification of colorectal cancer: A prognostic tool and potential challenge for adjuvant therapy trials. Cancer 2020; 126(4):681\u201390.","DOI":"10.1093\/jncics\/pkaa023"},{"key":"163476_B12","doi-asserted-by":"crossref","unstructured":"Xu JL, Yang MX, Lan HR, et al. Could Immunoscore improve the prognostic and therapeutic management in patients with solid tumors? Int Immunopharmacol 2023; 124:110981.","DOI":"10.1016\/j.intimp.2023.110981"},{"key":"163476_B13","doi-asserted-by":"crossref","unstructured":"Mlecnik B, Torigoe T, Bindea G, et al. Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study. Cancers (Basel) 2022; 14(18):434.","DOI":"10.3390\/cancers14184346"},{"key":"163476_B14","doi-asserted-by":"crossref","unstructured":"Sidaway P. Immunoscore provides a more accurate prognosis. Nat Rev Clin Oncol 2018; 15:471.","DOI":"10.1038\/s41571-018-0050-y"}],"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/163476\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/163476\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=163476&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:15:25Z","timestamp":1785996925000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/163476\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,6]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.68.e163476","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"e163476"}}