{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T13:14:27Z","timestamp":1771938867095,"version":"3.50.1"},"reference-count":25,"publisher":"Pensoft Publishers","issue":"1","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Introduction<\/jats:bold>\n                    : Peripheral nerve schwannomas are rare benign tumors. The onset of a schwannoma in the sciatic nerve is uncommon and can impair the nerve\u2019s functionality. To this date, the literature on this topic is mainly composed of case reports, lacking large case series.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim<\/jats:bold>\n                    : To overcome the limitations of previous literature, we performed a retrospective study on surgical enucleation of sciatic nerve schwannomas, evaluating surgical treatment\u2019s clinical and functional effectiveness.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods<\/jats:bold>\n                    : We examined retrospectively all cases of sciatic nerve schwannomas that underwent surgical enucleation between 2016 and 2022. For each one, we analyzed lesion size and localization. Motor and sensory deficits, Tinel sign, and lower limb functionality (assessed using MSTS and LEFS score) were evaluated before surgery and at the patients\u2019 latest follow-up.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Eight cases were included in our study. All patients had pre-operative sensory deficits. The mean MRC score was 3.9 before surgery, while MSTS and LEFS scores were 21.1 and 59.5, respectively. No local recurrence or major complication were recorded. After surgery, the mean MRC score rose to 5, and both MSTS scores (29.5) and LEFS scores (78.1) significantly increased compared to pre-operative records.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : In our cohort, good functional performances and symptomatic relief were seen after the removal of sciatic nerve schwannomas. Early diagnosis and prompt surgical treatment should represent the therapeutic approach for sciatic neurinomas, considering the good postoperative outcomes.\n                  <\/jats:p>","DOI":"10.3897\/folmed.68.e164570","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:35:02Z","timestamp":1771936502000},"source":"Crossref","is-referenced-by-count":0,"title":["More than just sciatica. Clinical presentation, surgical treatment and functional outcomes of sciatic nerve schwannomas"],"prefix":"10.3897","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-6357","authenticated-orcid":true,"given":"Edoardo","family":"Ipponi","sequence":"first","affiliation":[{"name":"University of Pisa - Department of Orthopedics and Trauma Surgery, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizia","family":"Gentili","sequence":"additional","affiliation":[{"name":"University of Pisa - Department of Orthopedics and Trauma Surgery, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9106-4874","authenticated-orcid":true,"given":"Francesco Rosario","family":"Campo","sequence":"additional","affiliation":[{"name":"University of Pisa - Department of Orthopedics and Trauma Surgery, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-7071","authenticated-orcid":true,"given":"Fabio","family":"Cosseddu","sequence":"additional","affiliation":[{"name":"University of Pisa - Department of Orthopedics and Trauma Surgery, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-5944","authenticated-orcid":true,"given":"Antonio","family":"D'Arienzo","sequence":"additional","affiliation":[{"name":"University of Pisa - Department of Orthopedics and Trauma Surgery, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-7104","authenticated-orcid":true,"given":"Paolo Domenico","family":"Parchi","sequence":"additional","affiliation":[{"name":"University of Pisa - Department of Orthopedics and Trauma Surgery, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8268-6987","authenticated-orcid":true,"given":"Lorenzo","family":"Andreani","sequence":"additional","affiliation":[{"name":"University of Pisa - Department of Orthopedics and Trauma Surgery, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"164570_B1","doi-asserted-by":"crossref","unstructured":"Ferner RE, O\u2019Doherty MJ. Neurofibroma and schwannoma. Curr Opin Neurol 2002; 15:679\u201384.","DOI":"10.1097\/01.wco.0000044763.39452.aa"},{"key":"164570_B2"},{"key":"164570_B3","doi-asserted-by":"crossref","unstructured":"Telera S, Raus L, Vietti V, et al. Schwannomas of the sciatic nerve: a rare and neglected diagnosis. A review of the literature with two illustrative cases. Clin Neurol Neurosurg 2020; 195:105889.","DOI":"10.1016\/j.clineuro.2020.105889"},{"key":"164570_B4"},{"key":"164570_B5","doi-asserted-by":"crossref","unstructured":"Knight DMA, Birch R, Pringle J. Benign solitary schwannomas: a review of 234 cases. J Bone Joint Surg [Br] 2007; 89-B:382\u20137.","DOI":"10.1302\/0301-620X.89B3.18123"},{"key":"164570_B6"},{"key":"164570_B7"},{"key":"164570_B8"},{"key":"164570_B9"},{"key":"164570_B10"},{"key":"164570_B11"},{"key":"164570_B12"},{"key":"164570_B13"},{"key":"164570_B14"},{"key":"164570_B15"},{"key":"164570_B16"},{"key":"164570_B17"},{"key":"164570_B18"},{"key":"164570_B19"},{"key":"164570_B20"},{"key":"164570_B21"},{"key":"164570_B22","unstructured":"Andreani L, Ipponi E, Ruinato DA, et al. Schwannomas of the peroneal nerves: Clinical and functional results of surgical treatment. J Musculoskelet Neuronal Interact 2022; 22(1):87\u201392."},{"key":"164570_B23"},{"key":"164570_B24"},{"key":"164570_B25"}],"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/164570\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/164570\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=164570&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:35:08Z","timestamp":1771936508000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/164570\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,24]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.68.e164570","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"article-number":"e164570"}}