{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:33:19Z","timestamp":1786613599783,"version":"build-2736575974"},"reference-count":10,"publisher":"Pensoft Publishers","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>\n                    <jats:bold>Abstract<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>Congenital melanocytic nevus (CMN) is predominantly distinguished by the presence of nevomelanocytes or nevus cells arranged in well-ordered clusters within the epidermis, as well as organized in the dermis. Giant congenital melanocytic nevus (GCMN) is an uncommon dermal lesion defined by benign proliferative growths of nevomelanocytes that are present at the time of birth. CMNs arise in utero between the 5th and 24th weeks of gestation, attributable to localized genetic anomalies that provoke the excessive proliferation of melanocytes. In individuals with giant CMN, a gain-of-function mutation in the NRAS gene is identified, leading to the aberrant proliferation of embryonic melanoblasts. Previously, elucidation of a murine model for giant congenital nevus demonstrated that both nevi and melanoma exhibit significant expression of Sox10. CMNs represent aggregates of melanocytes situated within the dermis, with varying degrees of extension into subcutaneous adipose tissue, musculature, and peri-adnexal regions. The present report deals with unveiling the embryological and molecular basis of congenital melanocytic nevus.<\/jats:p>","DOI":"10.3897\/folmed.68.e172212","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:26:06Z","timestamp":1786613166000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare case of giant congenital melanocytic nevus: its embryological and molecular basis"],"prefix":"10.3897","volume":"68","author":[{"given":"Akanksha","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Anatomy, Era\u2019s Lucknow Medical College and Hospital, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahsin","family":"Munsif","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Era\u2019s Lucknow Medical College and Hospital, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabeeh","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Surgery, Era\u2019s Lucknow Medical College and Hospital, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariyam","family":"Fatima","sequence":"additional","affiliation":[{"name":"MBBS Intern, FH Medical College, Agra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tashbiya","family":"Zehra","sequence":"additional","affiliation":[{"name":"MBBS \u2013 4th year, FH Medical College, Agra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qaim","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Era\u2019s Lucknow Medical College and Hospital, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"172212_B1","doi-asserted-by":"crossref","unstructured":"Barnhill RL, Fleischli M. Histologic features of congenital melanocytic nevi in infants 1 year of age or younger. J Am Acad Dermatol 1995; 33(5 Pt 1):780\u20135.","DOI":"10.1016\/0190-9622(95)91816-7"},{"key":"172212_B2","doi-asserted-by":"crossref","unstructured":"Kovalyshyn I, Braun R, Marghoob A. Congenital melanocytic naevi. Australas J Dermatol 2009; 50(4):231\u201340; quiz 241-2.","DOI":"10.1111\/j.1440-0960.2009.00553_1.x"},{"key":"172212_B3","unstructured":"Escandon-Perez S, Landeta-Sa AP, Gonzalez-Jasso Y, et al. Giant congenital melanocytic nevi. Bol Med Hosp Infant Mex 2019; 76(6):251\u20138."},{"key":"172212_B4","doi-asserted-by":"crossref","unstructured":"Alikhan A, Ibrahimi OA, Eisen DB. Congenital melanocytic nevi: where are we now? Part I. Clinical presentation, epidemiology, pathogenesis, histology, malignant transformation, and neurocutaneous melanosis. J Am Acad Dermatol 2012; 67(4):495.e1\u201317; quiz 512-4.","DOI":"10.1016\/j.jaad.2012.06.023"},{"key":"172212_B5","doi-asserted-by":"crossref","unstructured":"Charbel C, Fontaine RH, Malouf GG, et al. NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi. J Invest Dermatol 2014; 134:1067\u201374.","DOI":"10.1038\/jid.2013.429"},{"key":"172212_B6","doi-asserted-by":"crossref","unstructured":"Krengel S, Hauschild A, Schafer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Brit J Dermatol 2006; 155:1\u20138.","DOI":"10.1111\/j.1365-2133.2006.07218.x"},{"key":"172212_B7","doi-asserted-by":"crossref","unstructured":"Shakhova O, Zingg D, Schaefer SM, et al. Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma. Nature Cell Biol 2012; 14:882\u201390.","DOI":"10.1038\/ncb2535"},{"key":"172212_B8","doi-asserted-by":"crossref","unstructured":"Ibrahimi OA, Alikhan A, Eisen DB. Congenital melanocytic nevi: where are we now? Part II. Treatment options and approach to treatment. J Am Acad Dermatol 2012; 67(4):515.e1\u201313; quiz 528-30.","DOI":"10.1016\/j.jaad.2012.06.022"},{"key":"172212_B9","doi-asserted-by":"crossref","unstructured":"Etchevers HC. Hiding in plain sight: molecular genetics applied to giant congenital melanocytic nevi. J Invest Dermatol 2014; 134:879\u201382.","DOI":"10.1038\/jid.2013.531"},{"key":"172212_B10","doi-asserted-by":"crossref","unstructured":". Krengel S, Scope A, Dusza SW, et al. New recommendations for the categorization of cutaneous features of congenital melanocytic nevi. J Am Acad Dermatol 2013; 68(3):441\u201351.","DOI":"10.1016\/j.jaad.2012.05.043"}],"container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"https:\/\/foliamedica.bg\/article\/172212\/download\/pdf\/","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article\/172212\/download\/xml\/","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/foliamedica.bg\/article_preview.php?id=172212&skip_redirect=1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:26:11Z","timestamp":1786613171000},"score":1,"resource":{"primary":{"URL":"https:\/\/foliamedica.bg\/article\/172212\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8,13]]}},"URL":"https:\/\/doi.org\/10.3897\/folmed.68.e172212","relation":{},"ISSN":["1314-2143","0204-8043"],"issn-type":[{"value":"1314-2143","type":"electronic"},{"value":"0204-8043","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"article-number":"e172212"}}