{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:44:19Z","timestamp":1782841459303,"version":"3.54.5"},"reference-count":25,"publisher":"Pensoft Publishers","issue":"3","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FM"],"abstract":"<jats:p>\n                    <jats:bold>Introduction<\/jats:bold>\n                    : Monosodium glutamate (MSG) is extensively used in processed foods to enhance umami flavor, and its lingering presence in the oral cavity may influence salivary composition and microbial activity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods<\/jats:bold>\n                    : This pilot cross-sectional observational study was conducted at the Dental Institute, between March 2025 and April 2025. Twenty healthy participants aged 18\u201335 years were recruited using convenience random sampling. Unstimulated whole saliva samples were collected under standardized conditions, and salivary monosodium glutamate levels were quantified using a derivatization-based high-performance liquid chromatography (HPLC) method. Dental caries experience was assessed clinically using the Decayed, Missing, and Filled Teeth (DMFT) index and caries index (CI). Associations were explored using non-parametric correlation analysis and exploratory logistic regression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Participants with higher DMFT scores showed higher salivary MSG concentrations. Salivary MSG levels showed a significant positive association with dental caries (\u03c1=0.62,\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt;0.01). Logistic regression analysis indicated that higher MSG levels were associated with increased odds of belonging to the higher caries experience group (OR=1.05,\n                    <jats:italic>p<\/jats:italic>\n                    =0.03).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : Salivary MSG concentration demonstrated an association with dental caries development. Future larger and longitudinal studies are warranted to ascertain the role of salivary MSG as a non-invasive indicator of caries risk.\n                  <\/jats:p>","DOI":"10.3897\/folmed.68.e173421","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:47:05Z","timestamp":1782838025000},"source":"Crossref","is-referenced-by-count":0,"title":["Biochemical profiling of salivary monosodium glutamate in relation to dental caries: An observational analytical study"],"prefix":"10.3897","volume":"68","author":[{"given":"Pravallika","family":"Kakada","sequence":"first","affiliation":[{"name":"Saveetha Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monal","family":"Yuwanati","sequence":"additional","affiliation":[{"name":"Saveetha Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"173421_B1","doi-asserted-by":"crossref","unstructured":"Maluly HD, Arisseto\u2010Bragotto AP, Reyes FG. 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Cham: Springer International Publishing 2023 Sep 13 (pp. 147\u201363)","DOI":"10.1007\/978-3-031-32692-9_7"},{"key":"173421_B6","unstructured":"Kumar BL, Bharathwaj VV, Rajmohan M, et al. Effect of monosodium glutamate on salivary glands: A systematic review. J Advan Med Dental Sci Res 2022; 10(12):72\u20137."},{"key":"173421_B7","unstructured":"World Health Organization. Global oral health status report: towards universal health coverage for oral health by 2030. World Health Organization 2022 Nov 18"},{"key":"173421_B8","unstructured":"Reddy P, Krithikadatta J, Srinivasan V, et al. Dental caries profile and associated risk factors among adolescent school children in an Urban South-Indian city. Oral Health Prevent Dent 2020; 18(2):a43368."},{"key":"173421_B9","doi-asserted-by":"crossref","unstructured":"Devan I, Ramanarayanan V, Janakiram C. Prevalence of early childhood caries in India: A systematic review and meta-analysis. 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Diagnostic accuracy of different caries risk assessment methods. A systematic review. J Dentist 2015; 43(12):1385\u201393.","DOI":"10.1016\/j.jdent.2015.10.011"},{"key":"173421_B19","unstructured":"World Health Organization. Oral health surveys: basic methods. World Health Organization. 2013."},{"key":"173421_B20","doi-asserted-by":"crossref","unstructured":"Moradi G, Bolbanabad AM, Moinafshar A, et al. Evaluation of oral health status based on the decayed, missing and filled teeth (DMFT) index. Iranian J Public Health 2019; 48(11):2050.","DOI":"10.18502\/ijph.v48i11.3524"},{"key":"173421_B21","doi-asserted-by":"crossref","unstructured":"Petit P, Vuillerme N. Leveraging administrative health databases to address health challenges in farming populations: scoping review and bibliometric analysis (1975-2024). 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