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The structures, including absolute configurations, were determined using NMR spectroscopy, HRESIMS analysis, and computational methods (ECD, \u00b9\u00b3C NMR data, and optical rotation). A comprehensive library of SMs was established, enabling metabolomics-wide association studies that identified culture conditions as a key factor influencing SM production. This compound library also facilitates the determination of absolute configurations for diplosporins by analyzing <jats:italic>J<\/jats:italic> values and CD trends. Anti-proliferative tests against induced T\/B lymphocytes and HaCaT cells revealed that over half of the compounds exhibited significant inhibitory activity, with compounds <jats:bold>2<\/jats:bold>, <jats:bold>15<\/jats:bold>, and <jats:bold>32<\/jats:bold> reducing IFN-<jats:italic>\u03b3<\/jats:italic> secretion. Compound <jats:bold>32<\/jats:bold> demonstrated promising anti-psoriatic effects by inhibiting NF-<jats:italic>\u03ba<\/jats:italic>B p65 phosphorylation in HaCaT cells. This initial systematic chemical study of <jats:italic>X. longipes<\/jats:italic> under different conditions provides insights into structure\u2013activity relationships.<\/jats:p>","DOI":"10.3897\/imafungus.16.153522","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T12:55:14Z","timestamp":1755003314000},"source":"Crossref","is-referenced-by-count":2,"title":["Diverse metabolites with anti-psoriasis potential from different fermentations of the fungicolous fungus Xylaria longipes HFG1018"],"prefix":"10.3897","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-4694","authenticated-orcid":true,"given":"Zhen-Zhu","family":"Zhao","sequence":"first","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-4367","authenticated-orcid":true,"given":"Zhen-Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Le","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8914-219X","authenticated-orcid":true,"given":"Xin","family":"Pang","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Sheng","family":"Feng","sequence":"additional","affiliation":[{"name":"Henan University of Chinese Medicine, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2258","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"issue":"1","key":"153522_B1","first-page":"21","article-title":"\u03b2-carbolines, psychoactive compounds in the mammalian body. 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