{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:56:48Z","timestamp":1777391808750,"version":"3.51.4"},"reference-count":49,"publisher":"Pensoft Publishers","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PHAR"],"abstract":"<jats:p>Rheumatoid arthritis (RA) is a progressive and chronic systemic autoimmune disease. However, currently treatment is often carried out using NSAIDs and corticosteroids. Although it reduces symptoms, this treatment has a high rate of side effects. This study aims to determine the anti-inflammatory property of <jats:italic>Curcuma heyneana<\/jats:italic> so that it can be used as an alternative treatment for RA. Based on author knowledge, this study on <jats:italic>C. heyneana<\/jats:italic> from the Indonesian region for the treatment of RA is still limited. <jats:italic>C. heyneana<\/jats:italic>\u2019s rhizome was extracted by maceration with ethanol followed by fractionation process using <jats:italic>n<\/jats:italic>-hexane, ethyl acetate, and <jats:italic>n<\/jats:italic>-butanol. The anti-inflammatory <jats:italic>invitro<\/jats:italic> activities were determined by heat-induced hemolysis, effect on protein denaturation, and cyclooxygenases (COX) inhibition assay. Molecular docking of major predictive compounds was performed by AutoDock Vina. The results showed that some fractions of <jats:italic>C. heyneana<\/jats:italic> contained terpenoids, flavonoids, and alkaloids. The ethyl acetate fraction exhibited the highest anti-inflammatory activity, which was attributed to the presence of curcuminoids. Molecular docking studies further confirmed the potential of demethoxycurcumin, a curcuminoid identified in the ethyl acetate fraction, to inhibit COX-2. These findings suggest that <jats:italic>C. heyneana<\/jats:italic>, particularly its previously unreported curcuminoid-rich fractions, holds promise as a natural anti-inflammatory agent. Further research is warranted to explore the therapeutic potential of this plant in the management of RA and other inflammatory disorders.<\/jats:p>","DOI":"10.3897\/pharmacia.71.e120886","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T14:54:43Z","timestamp":1732546483000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["Anti-inflammatory potential of Curcuma heyneana: An in vitro and in silico investigation"],"prefix":"10.3897","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9510-6822","authenticated-orcid":true,"given":"Melanny Ika","family":"Sulistyowaty","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-5389","authenticated-orcid":true,"given":"Fifteen Aprila","family":"Fajrin","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-4392","authenticated-orcid":true,"given":"Mohammad Rizki Fadhil","family":"Pratama","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-6054","authenticated-orcid":true,"given":"Dwi","family":"Setyawan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7073-2421","authenticated-orcid":true,"given":"Anastasia Wheni","family":"Indrianingsih","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-3621","authenticated-orcid":true,"given":"Galih Satrio","family":"Putra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-5933","authenticated-orcid":true,"given":"Sabry A. 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