{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:25:56Z","timestamp":1791257156951,"version":"4.1.0"},"reference-count":15,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Fc\u03b3receptors (Fc\u03b3R) have important functions in the regulation of immune response and clearance of immune complex. High levels of immunoglobulins have been observed in patients with the active stage of adult onset Still\u2019s disease (AOSD), and high-dose intravenous immunoglobulin treatment has decreased the disease activity of AOSD. We investigated polymorphisms of Fc\u03b3R as genetic factors influencing susceptibility or disease course of AOSD in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We genotyped the Fc\u03b3RIIA H\/R131, IIIA F\/V176, and IIIB NA1\/NA2 loci in 98 patients with AOSD and 151 healthy controls. Genotyping was performed using sequence-specific PCR. Patients with AOSD were subdivided into groups according to disease course: monocyclic systemic, polycyclic systemic, or chronic articular type. Allelic, genotypic, and haplotypic associations were analyzed by chi-square test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>No significant skewing in any of the 3 Fc\u03b3R polymorphisms was found between Korean AOSD patients and controls. Fc\u03b3RIIA R\/R131 and R\/H131 genotype in patients with chronic articular-type disease was more frequent than in controls (p = 0.006 and p<jats:sub>corr<\/jats:sub> = 0.018). No differences of genotypic and allelic frequencies were found between other disease course types and controls. Haplotype IIA R131-IIIA F176-IIIB NA2 was more frequent in AOSD patients than in controls (p = 0.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Although Fc\u03b3R polymorphisms are not associated with development of AOSD in Koreans, the haplotype IIA R131-IIIA F176-IIIB NA2 may be associated with AOSD. Also, the Fc\u03b3RIIA polymorphism may be associated with chronic articular-type AOSD. We need to identify whether these polymorphisms are associated with a response to anti-tumor necrosis factor agents in patients with AOSD.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.071254","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T17:31:53Z","timestamp":1228498313000},"page":"347-350","source":"Crossref","is-referenced-by-count":8,"title":["Association of Fc\u03b3 Receptor Polymorphisms with Adult Onset Still\u2019s Disease in Korea"],"prefix":"10.3899","volume":"36","author":[{"given":"JIN-HYUN","family":"WOO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YOON-KYOUNG","family":"SUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JIN-SOOK","family":"LEE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WON TAE","family":"CHUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUNG-YOON","family":"CHOE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GWAN GYU","family":"SONG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAE-HYUN","family":"YOO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2009,2,9]]},"reference":[{"key":"2018112909184953000_36.2.347.1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939309010646"},{"key":"2018112909184953000_36.2.347.2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1380"},{"key":"2018112909184953000_36.2.347.3","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200004)43:4<740::AID-ANR4>3.0.CO;2-0"},{"key":"2018112909184953000_36.2.347.4","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00005792-199103000-00004","article-title":"Adult Still\u2019s disease: manifestations, disease course, and outcome in 62 patients","volume":"70","author":"Pouchot","year":"1991","journal-title":"Medicine Baltimore"},{"key":"2018112909184953000_36.2.347.5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1141"},{"key":"2018112909184953000_36.2.347.6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3346\/jkms.2002.17.1.75","article-title":"Association between Fc\u03b3R IIa and IIIa polymorphism and clinical manifestations in Korean patients with adult-onset Still\u2019s disease","volume":"17","author":"Oh","year":"2002","journal-title":"J Korean Med Sci"},{"key":"2018112909184953000_36.2.347.7","first-page":"424","article-title":"Preliminary criteria for classification of adult Still\u2019s disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol"},{"key":"2018112909184953000_36.2.347.8","first-page":"2189","article-title":"Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still\u2019s disease","volume":"31","author":"Chen","year":"2004","journal-title":"J Rheumatol"},{"key":"2018112909184953000_36.2.347.9","doi-asserted-by":"publisher","DOI":"10.1002\/art.10438"},{"key":"2018112909184953000_36.2.347.10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.3136"},{"key":"2018112909184953000_36.2.347.11","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-006-0090-y"},{"key":"2018112909184953000_36.2.347.12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119616"},{"key":"2018112909184953000_36.2.347.13","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.9.786"},{"key":"2018112909184953000_36.2.347.14","first-page":"1135","article-title":"Immunoglobulin G fc-receptor (Fc\u03b3R) IIA, IIIA, and IIIB polymorphisms related to disease severity in rheumatoid arthritis","volume":"29","author":"Brun","year":"2002","journal-title":"J Rheumatol"},{"key":"2018112909184953000_36.2.347.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.21266"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.071254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T12:18:41Z","timestamp":1543493921000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.071254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.3899\/jrheum.071254"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.071254","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}