{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:35:35Z","timestamp":1785515735542,"version":"3.56.0"},"reference-count":37,"publisher":"The Journal of Rheumatology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To describe the onset, clinical features, prognostic factors, and treatment of adult-onset Still\u2019s disease (AOSD) in cases from China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Sixty-one Chinese patients with AOSD were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Common clinical features were fever (100.0%), rash (88.5%), and arthritis (82.0%). The laboratory findings were as follows: leukocytosis (83.6%), increased erythrocyte sedimentation rate (100.0%), elevated transaminase concentrations (23.0%), elevated ferritin levels (79.6%), negative antinuclear antibody (88.5%), and negative rheumatoid factor (88.5%). Of the 61 patients, 44.3% exhibited a monocyclic disease pattern, 29.5% experienced disease relapse at least once, 16.4% exhibited chronic articular course, and 9.8% died; most deaths were due to pulmonary infection and respiratory failure. Based on the disease course, we divided the 61 patients into 2 groups: those with favorable outcome (cyclic disease course, n = 45) and unfavorable outcome (chronic disease course or death, n = 16). We analyzed the prognostic factors for the 2 groups, and found that pleuritis, interstitial pneumonia, elevated ferritin levels, and failure of fever to subside after 3 days of prednisolone at 1 mg\/kg\/day were unfavorable prognostic factors for patients with AOSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Patients with AOSD had complex symptoms with no specific laboratory findings. Our results indicate that AOSD is not a relatively benign disease, especially in cases that are refractory to high doses of prednisone.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.080365","type":"journal-article","created":{"date-parts":[[2009,5,12]],"date-time":"2009-05-12T20:14:10Z","timestamp":1242159250000},"page":"1026-1031","source":"Crossref","is-referenced-by-count":85,"title":["Clinical Features and Prognosis of Adult-onset Still\u2019s Disease: 61 Cases from China"],"prefix":"10.3899","volume":"36","author":[{"given":"TING","family":"ZENG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YU-QIONG","family":"ZOU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEI-FANG","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHENG-DE","family":"YANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2009,2,27]]},"reference":[{"key":"2018112909192549000_36.5.1026.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.042143"},{"key":"2018112909192549000_36.5.1026.2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2165\/00003495-200868030-00005","article-title":"Adult-onset Still\u2019s disease: Pathogenesis, clinical manifestations and therapeutic advances","volume":"3","author":"Kontzias","year":"2008","journal-title":"Drugs"},{"key":"2018112909192549000_36.5.1026.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.2.121"},{"key":"2018112909192549000_36.5.1026.4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/art.1780300209","article-title":"Adult onset Still\u2019s disease. 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