{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T22:50:50Z","timestamp":1648507850208},"reference-count":0,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We previously showed that Adamantiades-Beh\u00e7et\u2019s disease (A-BD) is associated with a lower incidence of malignancy compared with the general population. Transforming growth factor-\u03b2 (TGF-\u03b2) has been shown to play a role in cartilage regeneration and is increased in patients with A-BD. We also found 2 functional polymorphisms of the TGF-\u03b2 pathway, <jats:italic>TGFBR1*6A<\/jats:italic> and <jats:italic>TGFB1*CC<\/jats:italic>, that are associated with risk of malignancy. We tested whether incidence of these polymorphisms would differ in patients with A-BD compared with healthy controls of similar age and geographic location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a case-control study including 139 cases and 128 controls from Greece. Cases and controls were genotyped for <jats:italic>TGFBR1*6A<\/jats:italic> and <jats:italic>TGFB1*CC<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that cases had lower incidence of <jats:italic>TGFBR1*6A<\/jats:italic> compared with controls (11.3% vs 13.3%, respectively). Also, the incidence of <jats:italic>TGFB1*CC<\/jats:italic> was lower in cases than controls (24.6% vs 27.0%, respectively). These differences were not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although there is a suggestion that the lower incidence of <jats:italic>TGFBR1*6A<\/jats:italic> in A-BD patients may play a protective role against development of malignancy, larger studies would be needed to fully evaluate the role of TGF-\u03b2 and its polymorphisms in A-BD.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.080676","type":"journal-article","created":{"date-parts":[[2008,12,8]],"date-time":"2008-12-08T14:03:40Z","timestamp":1228745020000},"page":"2376-2378","source":"Crossref","is-referenced-by-count":4,"title":["Role of Polymorphisms in Adamantiades-Beh\u00e7et\u2019s Disease"],"prefix":"10.3899","volume":"35","author":[{"given":"VIRGINIA G.","family":"KAKLAMANI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAUREEN","family":"SADIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YVONI","family":"KOUMANTAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PHEDON","family":"KAKLAMANIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BORIS","family":"PASCHE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2008,12,1]]},"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.080676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T12:18:05Z","timestamp":1543493885000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.080676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.3899\/jrheum.080676"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.080676","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}