{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:04:33Z","timestamp":1759341873416},"reference-count":52,"publisher":"The Journal of Rheumatology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To investigate the potential implication of several polymorphisms of the C-reactive protein (<jats:italic>CRP<\/jats:italic>) gene in the predisposition to or clinical expression of giant cell arteritis (GCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A total of 125 patients diagnosed with biopsy-proven GCA and 234 ethnically matched controls from the Lugo region of Northwestern Spain were included in our study. Four functional gene polymorphisms for <jats:italic>CRP<\/jats:italic> rs1417938, rs1800947, rs1205, and rs3093059 variants were assessed using a polymerase chain reaction system with predeveloped TaqMan allelic discrimination assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Although we observed a significant increase in the frequency of heterozygotes for rs1417938 A\/T [odds ratio (OR) = 1.70; 95% confidence interval (CI) 1.04\u20132.80; p = 0.03] and rs1205 C\/T (OR 1.73; 95% CI 1.07\u20132.78; p = 0.02) in patients with GCA, no statistically significant differences in the allelic frequencies of these 2 polymorphisms were found between patients with GCA and controls. A marginal significant increase in the frequency of rs3093059 allele T in patients with GCA compared to controls was observed (OR 1.81; 95% CI 0.97\u20133.39; p = 0.04). However, the increased frequency of patients with GCA homozygous for rs3093059 T\/T in patients with GCA compared to controls was out of the range of significance (OR 1.77; 95% CI 0.92\u20133.40; p = 0.07). No significant differences were found when we stratified patients with GCA according to the presence of polymyalgia rheumatica or severe ischemic complications of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The functional <jats:italic>CRP<\/jats:italic> gene polymorphisms assessed in our study do not seem to play a major role in the pathogenesis of GCA in individuals from Northwestern Spain.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.080707","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T17:31:53Z","timestamp":1228498313000},"page":"341-346","source":"Crossref","is-referenced-by-count":10,"title":["C-Reactive Protein Gene Polymorphisms in Biopsy-proven Giant Cell Arteritis from Northwestern Spain"],"prefix":"10.3899","volume":"36","author":[{"given":"ROGELIO","family":"PALOMINO-MORALES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMAS R.","family":"VAZQUEZ-RODRIGUEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSE A.","family":"MIRANDA-FILLOY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAVIER","family":"MARTIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIGUEL A.","family":"GONZALEZ-GAY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2009,2,9]]},"reference":[{"key":"2018112909184952000_36.2.341.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70232-5"},{"key":"2018112909184952000_36.2.341.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011913"},{"key":"2018112909184952000_36.2.341.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000030185.67510.C0"},{"key":"2018112909184952000_36.2.341.4","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000180043.19285.54"},{"issue":"Suppl","key":"2018112909184952000_36.2.341.5","first-page":"S23","article-title":"Laboratory investigations useful in giant cell arteritis and Takayasu\u2019s arteritis","volume":"21","author":"Salvarani","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"2018112909184952000_36.2.341.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000066907.83923.32"},{"key":"2018112909184952000_36.2.341.7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01164.2005"},{"key":"2018112909184952000_36.2.341.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000084640.21712.9C"},{"key":"2018112909184952000_36.2.341.9","doi-asserted-by":"publisher","DOI":"10.1086\/431366"},{"key":"2018112909184952000_36.2.341.10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.591271"},{"key":"2018112909184952000_36.2.341.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.08.018"},{"key":"2018112909184952000_36.2.341.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.07.033"},{"key":"2018112909184952000_36.2.341.13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363820"},{"key":"2018112909184952000_36.2.341.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00703-1"},{"key":"2018112909184952000_36.2.341.15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.22.2703"},{"key":"2018112909184952000_36.2.341.16","first-page":"251","article-title":"Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. 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