{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:04:43Z","timestamp":1761512683185},"reference-count":16,"publisher":"The Journal of Rheumatology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To identify the significance of serum cartilage oligomeric matrix protein (COMP), a marker of cartilage turnover, in patients with early-stage rheumatoid arthritis (RA) in relation to other serologic variables and magnetic resonance imaging (MRI) features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Ninety-eight patients with early-stage RA, whose disease duration from onset was less than 2 years, were enrolled. The objective measures at baseline were Disease Activity Score (DAS28), serum C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of both wrist and finger joints. The MRI features included the number of sites scored positive for synovitis, bone edema, and bone erosion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Serum COMP concentration was not different among groups identified with low, moderate, and high DAS28-CRP values. However, COMP values were statistically high in subjects positive for bone erosions on MRI compared with the subjects who were negative for bone erosions. A positive correlation of COMP with CRP and with MMP-3 values was also identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Elevation of COMP may reflect joint damage that is dependent on the synovial inflammatory process in early-stage RA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.080926","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T21:11:09Z","timestamp":1242421869000},"page":"1126-1129","source":"Crossref","is-referenced-by-count":26,"title":["High Serum Cartilage Oligomeric Matrix Protein Determines the Subset of Patients with Early-Stage Rheumatoid Arthritis with High Serum C-Reactive Protein, Matrix Metalloproteinase-3, and MRI-Proven Bone Erosion"],"prefix":"10.3899","volume":"36","author":[{"given":"KEITA","family":"FUJIKAWA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATSUSHI","family":"KAWAKAMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAMI","family":"TAMAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MASATAKA","family":"UETANI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHOICHIRO","family":"TAKAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUHIKO","family":"ARIMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAOKI","family":"IWAMOTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOSHIYUKI","family":"ARAMAKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHINYA","family":"KAWASHIRI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KUNIHIRO","family":"ICHINOSE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAKOTO","family":"KAMACHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDEKI","family":"NAKAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TOMOKI","family":"ORIGUCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROAKI","family":"IDA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KIYOSHI","family":"AOYAGI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATSUMI","family":"EGUCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"2018112909194964000_36.6.1126.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22496"},{"key":"2018112909194964000_36.6.1126.2","first-page":"2154","article-title":"Bone edema determined by magnetic resonance imaging reflects severe disease status in patients with early-stage rheumatoid arthritis","volume":"34","author":"Tamai","year":"2007","journal-title":"J Rheumatol"},{"key":"2018112909194964000_36.6.1126.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.019992"},{"key":"2018112909194964000_36.6.1126.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.20316"},{"key":"2018112909194964000_36.6.1126.5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"2018112909194964000_36.6.1126.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.20365"},{"key":"2018112909194964000_36.6.1126.7","doi-asserted-by":"publisher","DOI":"10.1002\/art.21527"},{"key":"2018112909194964000_36.6.1126.8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/art.1780340502","article-title":"The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip","volume":"34","author":"Altman","year":"1991","journal-title":"Arthritis Rheum"},{"key":"2018112909194964000_36.6.1126.9","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"2018112909194964000_36.6.1126.10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.054205"},{"key":"2018112909194964000_36.6.1126.11","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.04138"},{"key":"2018112909194964000_36.6.1126.12","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.043075"},{"key":"2018112909194964000_36.6.1126.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.11162"},{"key":"2018112909194964000_36.6.1126.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.10747"},{"key":"2018112909194964000_36.6.1126.15","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO;2-R"},{"key":"2018112909194964000_36.6.1126.16","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.4.311"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.080926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T12:32:08Z","timestamp":1543494728000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.080926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,15]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,6,8]]},"published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.3899\/jrheum.080926"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.080926","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,15]]}}}