{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T20:25:03Z","timestamp":1715977503853},"reference-count":27,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Juvenile idiopathic arthritis (JIA) is generally considered to be caused by interaction of genetic and environmental factors. We investigated the association of a C-to-T transition in the promoter region of the CD14 gene on chromosome 5q31.1 and JIA in a Chinese Han population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>One hundred sixty-three children with JIA and 281 healthy children (age- and sex-matched to JIA group) were studied. Polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) was used for analysis of the genotypes. (Trial registration number ChiCTR-CCC-00000312.)<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>CD14 promoter-159 genotype frequencies of CC, CT, and TT were 11.48%, 49.18%, and 39.34%, respectively, in the systemic onset JIA group; 21.62%, 43.24%, and 35.14%, in the polyarticular JIA group; 16.67%, 50%, and 33.33%, in the oligoarticular JIA group; 6.9%, 75.86%, and 17.24%, in the group with other types of JIA; and 37.01%, 46.98%, and 16.01%, in the control group. Genotype frequency and allele frequency distribution were in accord with Hardy-Weinberg equilibrium. There were statistically significant differences in frequencies of genotype and allele in CD14 C-159T polymorphism between JIA group and control group (genotype: chi-squared = 33.168, p &lt; 0.05, CT vs CC, OR 2.946, 95% CI 1.739\u20134.990; TT vs CC, OR 5.426, 95% CI 2.977\u20139.891. Allele: chi-squared = 33.168, p &lt; 0.05, T vs C, OR 2.251, 95% CI 1.704\u20132.973). The T allele frequencies of boys and girls were significantly higher than those in the control group (p &lt; 0.001 of both).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>CD14 gene promoter C-159T polymorphism is significantly correlated with JIA in the Chinese Han population. The T allele of the C-159T polymorphism of CD14 gene may be a genetic risk factor for JIA.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.081093","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T01:56:06Z","timestamp":1247709366000},"page":"2025-2028","source":"Crossref","is-referenced-by-count":6,"title":["The Association with the \u2212159C\/T Polymorphism in the Promoter Region of the CD14 Gene and Juvenile Idiopathic Arthritis in a Chinese Han Population"],"prefix":"10.3899","volume":"36","author":[{"given":"HUA SONG","family":"ZENG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIANG YUAN","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XIAO 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