{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:11:33Z","timestamp":1778616693158,"version":"3.51.4"},"reference-count":20,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>We examined reported associations between radiographic hand osteoarthritis (OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha <jats:italic>(ESR1)<\/jats:italic> and beta <jats:italic>(ESR2).<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>In 539 Framingham Offspring Study participants (49% men; mean age 61 \u00b1 9 yrs) joint-specific radiographic hand OA was defined as Kellgren\/Lawrence (K\/L) scores \u2265 2 in the first carpometacarpal joint (CMC), distal interphalangeal joints (DIP), first-digit interphalangeal joint (IP), or proximal interphalangeal joints (PIP). Four SNP were genotyped for <jats:italic>ESR1<\/jats:italic> (PvuII-<jats:italic>rs2234693,<\/jats:italic> XbaI-<jats:italic>rs9340799, rs2077647,<\/jats:italic> and <jats:italic>rs1801132)<\/jats:italic> and 4 for <jats:italic>ESR2<\/jats:italic> (<jats:italic>rs1256031, rs1256034, rs1256059, rs944460).<\/jats:italic> Logistic regression analyses were performed to evaluate the relationships between genotypes and hand OA, adjusting for age, sex, height, and weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Radiographic hand OA was identified in at least one investigated joint of DIP (39%), PIP (33%), and first CMC (40%). There was no evidence of association between OA and genotype at any polymorphism. We found no significant association between our OA phenotypes or generalized or severe generalized OA as defined by Ushiyama and heterozygosity for <jats:italic>rs2234693<\/jats:italic> and <jats:italic>rs9340799,<\/jats:italic> although in metaanalysis with the former study this heterozygosity remained significantly associated with generalized or severe generalized OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>We found no significant association between hand OA and the investigated polymorphisms of <jats:italic>ESR1<\/jats:italic> or <jats:italic>ESR2<\/jats:italic> despite published reports of association and a priori hypotheses implicating their potential roles. However, we could not absolutely exclude associations with <jats:italic>rs2234693, rs9340799,<\/jats:italic> or <jats:italic>rs944460.<\/jats:italic><\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.081208","type":"journal-article","created":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T02:35:31Z","timestamp":1257215731000},"page":"2772-2779","source":"Crossref","is-referenced-by-count":13,"title":["The Relationship of Estrogen Receptor-\u03b1 and -\u03b2 Genes with Osteoarthritis of the Hand"],"prefix":"10.3899","volume":"36","author":[{"given":"BARTON L.","family":"WISE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SERKALEM","family":"DEMISSIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. ADRIENNE","family":"CUPPLES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID T.","family":"FELSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEI","family":"YANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMANDA M.","family":"SHEARMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PIRAN","family":"ALIABADI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID J.","family":"HUNTER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2009,11,2]]},"reference":[{"key":"2018112909213623000_36.12.2772.1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf141"},{"key":"2018112909213623000_36.12.2772.2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101540"},{"key":"2018112909213623000_36.12.2772.3","first-page":"46","article-title":"Heberden\u2019s nodes; the family history and radiographic appearance of a large family","volume":"5","author":"Stecher","year":"1953","journal-title":"Am J Hum Genet"},{"key":"2018112909213623000_36.12.2772.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.22.4.237"},{"key":"2018112909213623000_36.12.2772.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7036.940"},{"key":"2018112909213623000_36.12.2772.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"2018112909213623000_36.12.2772.7","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440170081009"},{"key":"2018112909213623000_36.12.2772.8","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199810)41:10<1867::AID-ART20>3.0.CO;2-W"},{"key":"2018112909213623000_36.12.2772.9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00001648-199607000-00013","article-title":"Estrogen replacement therapy and the development of osteoarthritis","volume":"7","author":"Oliveria","year":"1996","journal-title":"Epidemiology"},{"key":"2018112909213623000_36.12.2772.10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/ard.58.3.151","article-title":"Osteoarthrosis of the knee in men and women in association with overweight, smoking, and hormone therapy","volume":"58","author":"Sandmark","year":"1999","journal-title":"Ann Rheum Dis"},{"key":"2018112909213623000_36.12.2772.11","doi-asserted-by":"publisher","DOI":"10.1002\/art.20443"},{"key":"2018112909213623000_36.12.2772.12","doi-asserted-by":"publisher","DOI":"10.1002\/art.21621"},{"key":"2018112909213623000_36.12.2772.13","doi-asserted-by":"publisher","DOI":"10.1002\/art.11046"},{"key":"2018112909213623000_36.12.2772.14","first-page":"134","article-title":"Estrogen receptor gene polymorphism and generalized osteoarthritis","volume":"25","author":"Ushiyama","year":"1998","journal-title":"J Rheumatol"},{"key":"2018112909213623000_36.12.2772.15","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.41.3.279"},{"key":"2018112909213623000_36.12.2772.16","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199806)41:6<1064::AID-ART13>3.0.CO;2-K"},{"key":"2018112909213623000_36.12.2772.17","first-page":"1337","article-title":"Radiographic hand osteoarthritis: incidence, patterns, and influence of pre-existing disease in a population based sample","volume":"24","author":"Chaisson","year":"1997","journal-title":"J Rheumatol"},{"key":"2018112909213623000_36.12.2772.18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1432-1033.1973.tb02881.x","article-title":"Isolation of high-molecular-weight DNA from mammalian cells","volume":"36","author":"Gross-Bellard","year":"1973","journal-title":"Eur J Biochem"},{"key":"2018112909213623000_36.12.2772.19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"2018112909213623000_36.12.2772.20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.17.2263"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.081208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T17:34:26Z","timestamp":1543512866000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.081208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,2]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,12,4]]},"published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.3899\/jrheum.081208"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.081208","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,2]]}}}