{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:44:15Z","timestamp":1790246655259,"version":"4.1.0"},"reference-count":29,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>S100A8 and S100A9 are calcium binding proteins of the S100 family highly expressed in neutrophils and monocytes. S100 proteins are novel ligands of TLR4 important in modulating inflammation. High levels of S100A8\/A9 found in human inflammatory diseases are a marker of disease activity in rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA). We determined levels of S100A8\/A9 in sera of patients with systemic lupus erythematosus (SLE) and analyzed their relation to clinical variables of disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>A group of 93 patients with SLE were studied over a period of 3 years, and 143 serum samples were analyzed. S100A8\/A9 serum concentrations were determined by a sandwich ELISA. Sera from 10 primary Sj\u00f6gren\u2019s syndrome (pSS) patients and 50 healthy volunteers were used as controls. Correlations to SLEDAI, ANA, anti-dsDNA, WBC, CH50, C4, and CRP were made. In addition, infections were recorded in all SLE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Serum levels of S100A8\/A9 were significantly (p = 0.04) higher in SLE patients (1412 \u00b1 664 ng\/ml) versus healthy controls (339 \u00b1 35 ng\/ml) and pSS patients (400 \u00b1 85 ng\/ml). The only significant correlation (r = 0.219; p = 0.015) was found was between S100A8\/A9 and SLEDAI. Further, SLE patients with concomitant infections had higher serum levels of S100A8\/A9 (39300 \u00b1 13375 ng\/ml) than those without infections (1150 \u00b1 422 ng\/ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Serum levels of S100A8\/A9 are significantly raised in SLE versus pSS patients and healthy controls and can be correlated to a disease activity index. S100A8\/A9 is a more relevant marker of infection in SLE patients.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.081302","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T04:07:07Z","timestamp":1253074027000},"page":"2190-2194","source":"Crossref","is-referenced-by-count":107,"title":["Phagocyte-specific S100A8\/A9 Protein Levels During Disease Exacerbations and Infections in Systemic Lupus Erythematosus"],"prefix":"10.3899","volume":"36","author":[{"given":"MUHAMMAD S.","family":"SOYFOO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOHANNES","family":"ROTH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THOMAS","family":"VOGL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROLAND","family":"POCHET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUY","family":"DECAUX","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2009,9,15]]},"reference":[{"key":"2018112909212709000_36.10.2190.1","first-page":"69","article-title":"The multifunctional S100 protein family","volume":"172","author":"Heizmann","year":"2002","journal-title":"Methods Mol Biol"},{"key":"2018112909212709000_36.10.2190.2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0167-4889(98)00144-X","article-title":"Novel insights into structure and function of MRP8 and MRP 14","volume":"1448","author":"Kerkhoff","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"2018112909212709000_36.10.2190.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00062-0"},{"key":"2018112909212709000_36.10.2190.4","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10299"},{"key":"2018112909212709000_36.10.2190.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.3.236"},{"key":"2018112909212709000_36.10.2190.6","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1182\/blood.V82.6.1875.1875","article-title":"MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation are translocated to plasma membrane and intermediate filaments in a calcium dependent manner","volume":"82","author":"Roth","year":"1993","journal-title":"Blood"},{"key":"2018112909212709000_36.10.2190.7","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<628::AID-ANR20>3.0.CO;2-X"},{"key":"2018112909212709000_36.10.2190.8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00007890-199408000-00018","article-title":"Expression and complex formation of S100-like proteins MRP8 and MRP14 by macrophages during renal allograft rejection","volume":"58","author":"Goebeler","year":"1994","journal-title":"Transplantation"},{"key":"2018112909212709000_36.10.2190.9","doi-asserted-by":"publisher","DOI":"10.1038\/330080a0"},{"key":"2018112909212709000_36.10.2190.10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.5.669"},{"key":"2018112909212709000_36.10.2190.11","doi-asserted-by":"publisher","DOI":"10.1038\/nm1638"},{"key":"2018112909212709000_36.10.2190.12","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"2018112909212709000_36.10.2190.13","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/art.1780350606","article-title":"Derivation of the SLEDAI. 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