{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:55:29Z","timestamp":1780779329758,"version":"3.54.1"},"reference-count":32,"publisher":"The Journal of Rheumatology","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To determine the frequency and severity of gastrointestinal (GI) symptoms in patients with fibromyalgia (FM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>We included 152 women with FM (mean age 45.4 \u00b1 12.2 yrs), 98 women with rheumatoid arthritis (RA; mean age 45.5 \u00b1 12.3 yrs), and 60 healthy female controls (mean age 44 \u00b1 11.3 yrs). All patients were questioned about the severity of their chronic widespread pain, symptoms of FM, symptoms of dyspepsia, using a visual analog scale (VAS), and anxiety-depression scale. Patients were asked self-reported (yes\/no), symptom-based (\u2265 2 criteria) constipation and severity of constipation questions, and about the severity of quality of life (QOL) disturbance secondary to dyspepsia and constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Patients with FM had higher symptom severities for belching, reflux, bloating, sour taste, and vomiting than patients with RA and controls (all p values &lt; 0.01). Patients with FM had significantly more dyspepsia-related QOL disturbances than the other 2 groups (p &lt; 0.01). FM and RA patients had more frequent self-reported constipation than controls (respectively, 42.1%, 48%, 21.7%; p &lt; 0.01). The frequency of symptom-based constipation was significantly higher in the RA group (49%) than in FM (29.6%) and control groups (23.3%) (p &lt; 0.01). Constipation-related QOL disturbance was significantly higher in patients with FM than in controls (p &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>In patients with FM, the severity scores of dyspepsia symptoms, constipation, and dyspepsia-related QOL disturbance were higher than in patients with RA and controls. The higher GI symptom severity in patients with FM might have negative effects on their QOL.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.090024","type":"journal-article","created":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T02:29:06Z","timestamp":1246415346000},"page":"1720-1724","source":"Crossref","is-referenced-by-count":13,"title":["Increased Frequency of Gastrointestinal Symptoms in Patients with Fibromyalgia and Associated Factors: A Comparative Study"],"prefix":"10.3899","volume":"36","author":[{"given":"\u00d6MER NURI","family":"PAMUK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HASAN","family":"\u00dcMIT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ORBAY","family":"HARMANDAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"2018112909205155000_36.8.1720.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00470-1"},{"key":"2018112909205155000_36.8.1720.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(00)00139-2"},{"key":"2018112909205155000_36.8.1720.3","doi-asserted-by":"publisher","DOI":"10.1159\/000023349"},{"key":"2018112909205155000_36.8.1720.4","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1397::AID-ANR13>3.0.CO;2-7"},{"key":"2018112909205155000_36.8.1720.5","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1176\/ajp.148.12.1721","article-title":"Psychiatric status of patients with primary fibromyalgia, patients with rheumatoid arthritis, and subjects without pain: a blind comparison of DSM-III diagnoses","volume":"148","author":"Ahles","year":"1991","journal-title":"Am J Psychiatry"},{"key":"2018112909205155000_36.8.1720.6","unstructured":"Drossman DA Corazziari ES Talley NJ Thompson WG Whitehead WE Rome II . The functional gastrointestinal disorders: diagnosis, pathophysiology, and treatment: A multinational consensus. McLean, VA: Degnon Associates; 2000."},{"key":"2018112909205155000_36.8.1720.7","doi-asserted-by":"publisher","DOI":"10.1016\/0300-2977(95)00099-9"},{"key":"2018112909205155000_36.8.1720.8","first-page":"212","article-title":"Evaluation of the relationship between depression and fibromyalgia syndrome: why aren't all patients depressed?","volume":"27","author":"Okifuji","year":"2000","journal-title":"J Rheumatol"},{"key":"2018112909205155000_36.8.1720.9","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199306000-00010"},{"key":"2018112909205155000_36.8.1720.10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/00365529509093244","article-title":"What are the real problems for patients with functional dyspepsia?","volume":"30","author":"Haug","year":"1995","journal-title":"Scand J Gastroenterol"},{"key":"2018112909205155000_36.8.1720.11","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00006842-200011000-00015","article-title":"Seeking medical consultation: perceptual and behavioral characteristics distinguishing consulters and nonconsulters with functional dyspepsia","volume":"62","author":"Cheng","year":"2000","journal-title":"Psychosom Med"},{"key":"2018112909205155000_36.8.1720.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01377.x"},{"key":"2018112909205155000_36.8.1720.13","doi-asserted-by":"publisher","DOI":"10.1007\/s003840100299"},{"key":"2018112909205155000_36.8.1720.14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90265-D"},{"key":"2018112909205155000_36.8.1720.15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02229708"},{"key":"2018112909205155000_36.8.1720.16","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"2018112909205155000_36.8.1720.17","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"2018112909205155000_36.8.1720.18","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1176\/ajp.150.4.595","article-title":"Separation anxiety in panic disorder","volume":"150","author":"Free","year":"1993","journal-title":"Am J Psychiatry"},{"key":"2018112909205155000_36.8.1720.19","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00037-2"},{"key":"2018112909205155000_36.8.1720.20","first-page":"728","article-title":"The Fibromyalgia Impact Questionnaire: development and validation","volume":"18","author":"Burckhardt","year":"1991","journal-title":"J Rheumatol"},{"key":"2018112909205155000_36.8.1720.21","doi-asserted-by":"publisher","DOI":"10.1007\/s002960000077"},{"key":"2018112909205155000_36.8.1720.22","first-page":"1373","article-title":"Gastrointestinal symptoms and health related quality of life in patients with arthritis","volume":"27","author":"Wolfe","year":"2000","journal-title":"J Rheumatol"},{"issue":"Suppl","key":"2018112909205155000_36.8.1720.23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/11024159850191210","article-title":"The association of functional gastrointestinal disorders and fibromyalgia","volume":"583","author":"Chang","year":"1998","journal-title":"Eur J Surg"},{"key":"2018112909205155000_36.8.1720.24","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm0402_1"},{"key":"2018112909205155000_36.8.1720.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70272-6"},{"key":"2018112909205155000_36.8.1720.26","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9450.00284"},{"key":"2018112909205155000_36.8.1720.27","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/art.1780401103","article-title":"The neuroscience and endocrinology of fibromyalgia","volume":"40","author":"Pillemer","year":"1997","journal-title":"Arthritis Rheum"},{"key":"2018112909205155000_36.8.1720.28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906173402407"},{"key":"2018112909205155000_36.8.1720.29","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300088"},{"key":"2018112909205155000_36.8.1720.30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03155.x"},{"key":"2018112909205155000_36.8.1720.31","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537261"},{"key":"2018112909205155000_36.8.1720.32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05259.x"}],"container-title":["The Journal of Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3899\/jrheum.090024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T17:33:12Z","timestamp":1543512792000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jrheum.org\/lookup\/doi\/10.3899\/jrheum.090024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,30]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2009,8,11]]},"published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.3899\/jrheum.090024"],"URL":"https:\/\/doi.org\/10.3899\/jrheum.090024","relation":{},"ISSN":["0315-162X","1499-2752"],"issn-type":[{"value":"0315-162X","type":"print"},{"value":"1499-2752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,30]]}}}