{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:58:12Z","timestamp":1773154692485,"version":"3.50.1"},"reference-count":24,"publisher":"The Journal of Rheumatology","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To examine the purified protein derivative (PPD) response that develops depending upon Th1 immune response in children with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>PPD skin test was performed in 115 children with JIA who were vaccinated with bacillus Calmette-Guerin (BCG), and then they were compared to the PPD response of 45 healthy children of the same age who were vaccinated with BCG. Children with a PPD induration \u2265 5 mm were accepted as PPD-positive. PPD induration \u2265 10 mm was accepted as a limit for suspecting tuberculosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>PPD induration size and PPD positivity rates (PPD \u2265 5 mm) of children with JIA were significantly lower than those of healthy children. The mean of PPD induration size was significantly lower (p &lt; 0.0001) in patients with either 1 BCG vaccine (3.7 \u00b1 3.6) or more than 1 BCG vaccine than controls with either 1 BCG vaccine (7.10 \u00b1 3.2) or more than 1 BCG vaccine (10.05 \u00b1 4.1). PPD was positive in 35.9% of patients with JIA vaccinated once (n = 32), in 50% of patients with JIA vaccinated more than once (n = 13), in 82.1% of controls vaccinated once (n = 23), and in 88.2% of controls vaccinated more than once. This result was statistically significant (patients, p = 0.03; controls, p = 0.039). It was determined that neither the activity of the disease nor the use of corticosteroid and methotrexate affected the PPD response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The response to PPD, which is one of the Th1 cell-type responses, was significantly lower in BCG-vaccinated children with JIA compared to healthy children.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.090173","type":"journal-article","created":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T01:26:20Z","timestamp":1249089980000},"page":"2029-2032","source":"Crossref","is-referenced-by-count":13,"title":["Purified Protein Derivative Response in Juvenile Idiopathic Arthritis"],"prefix":"10.3899","volume":"36","author":[{"given":"EVRIM","family":"KIRAY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OZGUR","family":"KASAPCOPUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VEDAT","family":"BAS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AYLA","family":"KAMBUROGLU-GOKSEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KENAN","family":"MIDILLI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NIL","family":"ARISOY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUCEL","family":"TASTAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2009,7,31]]},"reference":[{"key":"2018112909211597000_36.9.2029.1","doi-asserted-by":"crossref","unstructured":"Cassidy JT Petty RE . Juvenile rheumatoid arthritis. In: Cassidy JT Petty RE , editors Textbook of pediatric rheumatology. 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