{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:40:38Z","timestamp":1774057238172,"version":"3.50.1"},"reference-count":34,"publisher":"The Journal of Rheumatology","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>Interleukin 18 (IL-18) has a central role in the pathogenesis of adult-onset Still\u2019s disease (AOSD). We investigated the functional association of \u2212607 (C\/A) IL-18 promoter polymorphisms with disease course in Chinese patients with AOSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Sequence-specific primer polymerase chain reaction and the restriction fragment-length polymorphism method were used to analyze the genotypes of IL-18 promoter polymorphism at position \u2212607 in 96 unrelated patients with AOSD and 164 ethnically-matched healthy controls. Serum IL-18 levels were determined using ELISA in patients with active untreated AOSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Significantly lower frequencies of single-nucleotide polymorphism \u2212607\/AA were observed in patients with AOSD compared to healthy controls (18.8% vs 31.1%, respectively; p &lt; 0.05). Median levels of serum IL-18 were significantly lower in AOSD patients with AA genotype compared to those with CA genotype or CC genotype (147.5 pg\/ml vs 410.5 pg\/ml or 262.4 pg\/ml, respectively; both p &lt; 0.05). Significantly lower IL-18 levels were demonstrated in AOSD patients with a monocyclic systemic course than in those with a polycyclic systemic course or a chronic articular course. The AA genotype was more frequently observed in patients with monocyclic systemic course, which had the best prognosis, than in those with the other 2 disease courses. In contrast, a lower frequency of the AA genotype than the CA or the CC genotype was observed in patients with chronic disabling arthritis (5.5% vs 25.0% or 19.2%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>The SNP \u2212607\/AA genotype with lower IL-18 levels might be a genetically protective factor for the occurrence of AOSD in the Chinese population, against progression of chronic disabling arthritis.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.090316","type":"journal-article","created":{"date-parts":[[2009,8,15]],"date-time":"2009-08-15T01:26:01Z","timestamp":1250299561000},"page":"2284-2289","source":"Crossref","is-referenced-by-count":31,"title":["Functional Association of Interleukin 18 Gene \u2212607 (C\/A) Promoter Polymorphisms with Disease Course in Chinese Patients with Adult-onset Still\u2019s Disease"],"prefix":"10.3899","volume":"36","author":[{"given":"DER-YUAN","family":"CHEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YI-MING","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HSIN-HUA","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHIA-WEI","family":"HSIEH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHI-CHEN","family":"LIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOUNG-LIANG","family":"LAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2262","published-online":{"date-parts":[[2009,8,14]]},"reference":[{"key":"2018112909212712000_36.10.2284.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.2.121"},{"key":"2018112909212712000_36.10.2284.2","first-page":"1139","article-title":"Adult Still\u2019s disease: Review of 228 cases from the literature","volume":"14","author":"Ohta","year":"1987","journal-title":"J Rheumatol"},{"key":"2018112909212712000_36.10.2284.3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00005792-199103000-00004","article-title":"Adult Still\u2019s disease: manifestations, disease course, and outcome in 62 patients","volume":"70","author":"Pouchot","year":"1991","journal-title":"Medicine"},{"key":"2018112909212712000_36.10.2284.4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/art.1780300209","article-title":"Adult-onset Still\u2019s disease: clinical course and outcome","volume":"30","author":"Cush","year":"1987","journal-title":"Arthritis Rheum"},{"key":"2018112909212712000_36.10.2284.5","first-page":"748","article-title":"Adult Still\u2019s disease. 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