{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:15:31Z","timestamp":1783538131542,"version":"3.55.0"},"reference-count":23,"publisher":"The Journal of Rheumatology","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Rheumatol"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To evaluate changes in symptoms, spinal mobility, and radiographic features in patients with axial psoriatic arthritis (AxPsA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Patients with AxPsA were identified from the University of Toronto Psoriatic Arthritis clinic database. Axial symptoms, metrology, and radiographic features at study entry were compared to 5-year and 10-year followup assessments. Data were analyzed using continuity adjusted McNemar\u2019s test, an exact binomial test, or logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Of 297 patients (mean age 42.5 yrs, PsA duration 8 yrs) in the study, 56% had axial symptoms, 43% had radiographic evidence of sacroiliitis, and 13% had syndesmophytes at entry. The number of patients with neck\/back pain, neck\/back stiffness, and clinical sacroiliitis declined significantly at both 5- and 10-year followup periods. There was a significant increase in the number of patients with restricted cervical spinal mobility at both 5- and 10-year visits and significant reduction in lateral flexion at both timepoints. At 5 (10) years, of those without sacroiliitis at baseline, 36.6% (51.7%) developed at least grade 2 sacroiliitis; 46.5% (52.0%) of those who presented with grade 2 progressed to a higher grade; and 15.6% (25.0%) with grade 3 progressed to grade 4 sacroiliitis. Of the patients without cervical\/thoracic\/lumbar syndesmophytes at study entry, 11%\/16%\/14% (14%\/21%\/20%) developed syndesmophytes in these regions at 5 (10) year followup. Similar results were obtained when analyses were restricted to patients satisfying radiographic criteria alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Over a 10-year period, patients with AxPsA had improvement in neck and back pain, but lateral spinal flexion and cervical mobility deteriorated.<\/jats:p><\/jats:sec>","DOI":"10.3899\/jrheum.090412","type":"journal-article","created":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T21:35:31Z","timestamp":1257197731000},"page":"2744-2750","source":"Crossref","is-referenced-by-count":104,"title":["Axial Psoriatic Arthritis: Update on a Longterm Prospective Study"],"prefix":"10.3899","volume":"36","author":[{"given":"VINOD","family":"CHANDRAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JESSICA","family":"BARRETT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CATHERINE T.","family":"SCHENTAG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VERNON T.","family":"FAREWELL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAFNA D.","family":"GLADMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2262","published-online":{"date-parts":[[2009,11,2]]},"reference":[{"key":"2018112909213646000_36.12.2744.1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0074-2"},{"key":"2018112909213646000_36.12.2744.2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0591"},{"key":"2018112909213646000_36.12.2744.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.47.5.386"},{"key":"2018112909213646000_36.12.2744.4","first-page":"127","article-title":"Psoriatic arthritis (PSA) \u2014 an analysis of 220 patients","volume":"62","author":"Gladman","year":"1987","journal-title":"Q J Med"},{"key":"2018112909213646000_36.12.2744.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"2018112909213646000_36.12.2744.6","unstructured":"Hoppenfeld S . 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